4,583 Works

Regulation and Functional Impact of Opioid Receptor Splicing in Response to Morphine

Multiple classes of pharmaceuticals, including acetaminophen, aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs), are used to relieve mild to moderate pain; however, one of the oldest classes of pharmaceuticals, opioids, remains the primary class of drugs used in the management of severe pain. For decades, the unique pharmacological profiles of opioid compounds have suggested the existence of multiple opioid receptor subtypes and, accordingly, four opioid receptors have been cloned to date; the mu (μ)-opioid receptor,...

Firearm Injury Prevention: Understanding Firearm Policy Diffusion, 1993-2010

Annually firearms kill more than 30,000 individuals and injure more than 50,000 individuals, resulting in costs of $45 million to over $1 billion in the United States. Traditionally firearms were addressed as a criminal justice problem, but for more than 30 years, public health and injury prevention specialists have worked to address the problem of firearm injuries through surveillance, education, research, and laws. Firearm legislation is multijurisdictional across the federal, state, and local governments, but...

Boys to Men: Reflections on Building Resilience in Young Black Male Students

Boys to Men: Building Resilience in Young Black Male Students Stuart Rhoden Doctor of Philosophy Temple University, 2013 Will J. Jordan, Ph.D. Chair The main purpose of this research was to help identify persistence as reported by Black male college students who were the inaugural graduates of the Class of 2011 from a predominantly Black, all-male Charter High School in the Mid-Atlantic region. Examining this population of students was significant because too often Black male...

The Potential of IL-19 As a Therapeutic Anti-inflammatory and Angiogenic Cytokine

Our lab has recently shown that IL-19 is expressed in angiogenic ECs, opening the possibility for its use as a medicine to increase perfusion in patients with PAD. The first aim of the current study is to show IL-19’s ability to increase perfusion in vivo using C57BL/6 wild type and IL-19 KO mice in the hindlimb ischemia (HLI) model. Wild-type mice injected with 10ng/g/day of rmIL-19 after being subject to hindlimb ischemia showed significantly greater...

The Texas Moment: Breakaway Republics and Contested Sovereignty in North America, 1836-1846

Between 1845 and 1848, the United States doubled the size of its land holdings in North America, as Texas, Oregon, California, New Mexico, and other western regions were placed under the umbrella of U.S. sovereignty. Echoing John L. O’Sullivan’s famous phrase, historians have deemed these acquisitions “Manifest Destiny,” and have assumed that U.S. expansion – whether for good or ill – was foreordained. Yet this understanding fundamentally fails to take into account the history of...

The Sanctioned Antiblackness of White Monumentality: Africological Epistemology as Compass, Black Memory, and Breaking the Colonial Map

In the cities of Richmond, Virginia; Charleston South Carolina; New Orleans, Louisiana; and Baltimore, Maryland, this dissertation endeavors to find out what can be learned about the archaeology(s) of Black memory(s) through Africological Epistemic Visual Storytelling (AEVS); their silences, their hauntings, their wake work, and their healing? This project is concerned with elucidating new African memories and African knowledges that emerge from a two-tier Afrocentric analysis of Eurocentric cartography that problematizes the dual hegemony of...

Pagan Roman Religious Acculturation? An Inquiry into the Domestic Cult at Karanis, Ephesos and Dura-Europos: The First to Fifth Centuries CE

The ancient Roman domestic cult is often overlooked and marginalized in favor of state sponsored practices, monuments, and temples; yet it can give us insights into daily life, cultural interactions, and personal identity in the Empire. In my dissertation, I recreate a selection of domestic contexts in order to learn more about private cultic practices, thus illuminating those activities and behaviors that may be far removed from what appears in the literary sources or in...

The Cannabinoid-2 Receptor Agonist O-1966 Reverses Postischemic Learning and Memory Deficits Through Anti-Inflammatory Processes

Ischemic stroke is the third leading cause of death and the leading cause of morbidity in the United States. Cognitive deficits, specifically with respect to learning and memory, are a significant contributor to morbidity in stroke patients. Unfortunately, current treatment options must be administered within a thin therapeutic window of the initial infarct. This requirement results in less than 10% of stroke patients being eligible for treatment. There are currently no treatment options that are...

OPEN INNOVATION CONTESTS IN ONLINE MARKETS: IDEA GENERATION AND IDEA EVALUATION WITH COLLECTIVE INTELLIGENCE

To overcome constrained resources, firms can actively seek innovative opportunities from the external world. This innovation approach, called open innovation (Chesbrough 2003; Hippel 2005; Terwiesch and Ulrich 2009; Terwiesch and Xu 2008), is receiving more and more attention. Facilitated by the global Internet and emerging forms of information technology, it has become very easy for companies to generate large numbers of innovative solutions through the use of online open innovation contests or crowdsourcing contests (Archak...

IDENTIFYING EARLY STEPS IN THE DEVELOPMENT OF HBV ASSOCIATED HCC

The hepatitis B virus (HBV), chronically infecting ~360 million people worldwide, accounts for over half of the cases of hepatocellular carcinoma (HCC) and contributes to over 650,000 deaths per year making HCC is the fifth most common and second most deadly form of cancer.1-3 Many genes deregulated by the hepatitis B x-antigen (HBx), the oncogenic protein encoded by HBV, are known drivers of HCC.4,5 The timing of these alterations in the initiation and progression of...

Amylin mediates brainstem control of heart rate in the diving reflex

Amylin, or islet amyloid polypeptide is a 37-amino acid member of the calcitonin peptide family. Amylin role in the brainstem and its function in regulating heart rates is unknown. The diving reflex is a powerful autonomic reflex, however no neuropeptides have been described to modulate its function. In this thesis study, amylin expression in the brainstem involving pathways between the trigeminal ganglion and the nucleus ambiguus was visualized and characterized using immunohistochemistry. Its functional role...

Investigating the Volume and Structure of Porosity in Fractured and Unfractured Rock from the Newberry Volcano, Oregon: An Evaluation and Comparison of Two- and Three- Dimensional Methods

Porosity is a fundamental characteristic of rock critical to its mechanical and hydrologic behavior, yet a study of the open and accumulated healed porosity of nine core samples from Newberry Volcano shows that different measurement methods produce significantly different estimates of pore volume and structure. This study compares traditional 2D point count, petrographic image analysis, and 3D x-ray Micro Computed Tomography (micro CT) measurement of porosity primarily derived from fracture slip and dilation. The set...

Sufficient Dimension Reduction in Complex Datasets

This dissertation focuses on two problems in dimension reduction. One is using permutation approach to test predictor contribution. The permutation approach applies to marginal coordinate tests based on dimension reduction methods such as SIR, SAVE and DR. This approach no longer requires calculation of the method-specific weights to determine the asymptotic null distribution. The other one is through combining clustering method with robust regression (least absolute deviation) to estimate dimension reduction subspace. Compared with ordinary...

Exploring Social Influences on Executive Function in Preschool Children

The development of executive function in young children is currently a central topic in developmental science. Despite great interest in this area, empirical research examining the influence of social interaction on children's executive functioning is still scarce. The present study aims to fill this gap by addressing how aspects of current and preceding social interactions affect preschool children's executive function performance. In the first phase of the experiment four- and five-year-old children completed an activity...

Iranian Documentary Film Culture: Cinema, Society, and Power 1997-2014

Iranian documentary filmmakers negotiate their relationship with power centers every step of the way in order to open creative spaces and make films. This dissertation covers their professional activities and their films, with particular attention to 1997 to 2014, which has been a period of tremendous expansion. Despite the many restrictions on freedom of expression in Iran, especially between 2009 and 2013, after the uprising against dubious election practices, documentary filmmakers continued to organize, remained...

The Role of Hedgehog signaling in Hepatitis B virus X protein mediated hepatocellular carcinoma

Hepatitis B virus encoded X protein (HBx) contributes centrally to the pathogenesis of hepatocellular carcinoma (HCC). Aberrant activation of the Hedgehog (Hh) pathway has been linked to cancer. Thus, experiments were designed to test the hypothesis that HBx contributes to HCC via activation of Hh signaling. HBx expression correlated with up-regulation of Hh markers in human liver cancer cell lines, in HBx transgenic mice that developed HCC and in liver samples from HBV infected patients...

Predictors of Client Responsiveness to the Bonny Method of Guided Imagery and Music (BMGIM)

The purpose of this study was to identify predictors of responsiveness to the Bonny Method of Guided Imagery and Music (BMGIM), as measured by the Responsiveness to Guided Imagery and Music scale (RGIM). It was hypothesized that when combined, Sense of Coherence (SOC), state trait anxiety (STAI), classical music experience (CME), gender, and/or age would account for a significant amount of variance in responsiveness to BMGIM. Sixty volunteer participants were recruited from the general population....

Unpacking the Coach-Athlete Relationship: The Role of Athlete Coping Skills Within a Framework of Self-Determination

Over the last 40 years, the field of sport psychology has generated a growing body of literature on the coach-athlete relationship, driven by the recognition that the quality of this dyad can play an important role in an athlete's experiences in sport. Despite strong evidence suggesting that Self-Determination Theory (SDT) accurately reflects processes within this relationship, which promote or undermine intrinsic motivation, there is room to deepen contemporary understandings of coach-athlete dyads by assessing the...

The Seals from the Minoan Site of Chryssi Island: Local, Regional, and Global Implications

Five seals come from a Minoan site on the island of Chryssi, just off the southeastern coast of Crete. Four of these seals are sealstones, and one is the bezel of a metal seal ring. These seals are important as individual objects to allow for a deeper understanding of the people that inhabited Chryssi Island during the Bronze Age, but a further understanding of the site itself is also garnered by expanding the focus to...

An Examination of Digital Nativity, Generation, and Gender in Online Giving

Charitable giving has been of great interest to marketing academics because of its importance in understanding the relationships between nonprofit organizations and their customers. The concept of motivation is vital to researchers because authors have long queried about why a donor decides to give money to a charity as opposed to saving, investing, or consuming discretionary goods with these dollars. The first study in this paper was exploratory in nature; in this study, a number...

Allowing Education Entrepreneurs to Flourish: How Do We Unlock Schools to Innovate?

If we want our students to be competitive internationally and to be better prepared for our evolving workforce, our leaders must support the identification, development, and implementation of innovative instructional models. This qualitative study used two sets of interviews to learn from school district principals, independent charter school principals, and charter management organization principals. At its most basic level, this study was designed to answer two questions that have been at the foundation of many...

Numerical Magnitude Knowledge: Are All Numbers Perceived Alike?

A robust knowledge of numbers, and their magnitudes, is thought to provide students a strong basis for later mathematics learning and achievement (see Siegler, 2016). The current study examined 7th grade students’ (N = 193) knowledge of numerical magnitudes, how this knowledge varied depending on the number’s type (integer or non-integer) and the number’s polarity (positive or negative), and the strategies that students use while estimating different types of numbers. The first experiment of the...

From \"Telling Transgender Stories\" to \"Transgender People Telling Stories\": Transgender Literature and the Lambda Literary Awards, 1997-2017

Transgender lives and identities have gained considerable popular notoriety in the past decades. As part of this wider visibility, dominant narratives regarding the “transgender experience” have surfaced in both the community itself and the wider public. Perhaps the most prominent of these narratives define transgender people as those living in the “wrong body” for their true gender identity. While a popular and powerful story, the wrong body narrative has been criticized as limited, not representing...

LOCUS OF CONTROL AND ACADEMIC ACHIEVEMENT: INTEGRATING SOCIAL LEARNING THEORY AND EXPECTANCY-VALUE THEORY

The current study examines predictors of math achievement and college graduation by integrating social learning theory and expectancy-value theory. Data came from a nationally-representative longitudinal database tracking 12,144 students over twelve years from 8th grade forward. Models for math achievement and college graduation were tested through structural equation modeling. Consistent with earlier research, previous math achievement predicted both outcomes. Performance expectancies and task-specific self-concept respectively predicted math achievement and college graduation, although the contribution of...

Essays on Corporate Finance

Much of the literature on investment-cash flow sensitivity examines only manufacturing firms, uses capital expenditure as a measure of investment, and uses operating cash flow as a measure of internal funds. Over the last several decades, due to outsourcing, the importance of manufacturing firms in the U.S. economy and the importance of capital expenditure as the primary type of investment have declined. The introduction of the Nasdaq exchange allowed smaller, less-profitable, and more human-capital intensive...

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