4,583 Works

CASPASE-1 ACTIVATION IS CRITICAL FOR ENDOTHELIAL CELL ACTIVATION, MONOCYTE MIGRATION, AND EARLY ATHEROGENESIS

Atherosclerosis, considered a chronic inflammatory disease, is the underlying mechanism for several cardiovascular diseases. Hyperlipidemia is the number one risk factor for atherogenesis. Caspase-1 is an inflammatory caspase, which can be activated by the metabolic stresses through pathogen associated molecular patterns (PAMPs)-recognition receptors, (PRR) recognition and inflammasome assembly. Activated caspase-1 can initiate inflammation in multiple ways. Thus, regulating inflammasome components expression is essential to control caspase-1 activation and its subsequent inflammatory processes. I hypothesized that...

EXPLICIT INSTRUCTION OF SPEECH ACTS AS ACTION SEQUENCE EVENTS: A VIDEO-BASED METHOD

This research involves three separate studies with the goal of investigating learner increases in the pragmatic awareness when exposed to various degrees of sustained, explicit instruction. Operationalized as a composite construct in the theory of communicative competence, pragmatic awareness includes knowledge of pragmalinguistic forms and sociopragmatic features, with sequential action events representing the former and relationship status categories the latter. Research questions for each study focus on gains learners revealed on a video-based pragmatic awareness...

National Narratives and Global Politics: Immigrant and Second-Generation Iranians in the United States and Germany

This dissertation project examines the lived experiences of immigrant and second- generation Iranian immigrants to uncover the factors that shape their perceptions of belonging in two differ western nations. It is a qualitative methods study that utilized in-depth interviews. I address the limitations of past research by highlighting that Iranians' experiences of belonging and membership in western nations are greatly influenced by the national narratives of their host societies and the global politics surrounding Iran....

MEDIA LITERACY EDUCATION TO PROMOTE CULTURAL COMPETENCE AND ADAPTATION AMONG DIVERSE STUDENTS: A CASE STUDY OF NORTH KOREAN REFUGEES IN SOUTH KOREA

This dissertation examines how media literacy education can be implemented and practiced for North Korean refugees to enhance their cultural competency. It is conducted as a form of participatory action research, which pursues knowledge and progressive social change. As a participant researcher, I taught media literacy to North Korean refugees in five different institutions during the summer of 2008 for a period of three months. This dissertation reviews my strategies for gaining permission and access...

TO PEE OR NOT TO PEE: A CHARACTERIZATION OF CANINE BLADDER PHYSIOLOGY FOLLOWING LONG-TERM LOWER SPINAL ROOT TRANSECTION AND SURGICAL REINNERVATION

Bladder incontinence in patients who suffer from sacral spinal cord injury can wreak havoc on one's quality of life. A 2012 survey suggests that patients who sustain spinal cord injury prioritize the recovery of bladder function over other faculties. With about 12,000 new spinal cord injury cases reported in the United States each year, finding ways to combat the disabilities that result from lower spinal cord dysfunction should be of utmost importance to the scientific...

A Comparative Study of How Career Services Staff Responds To Students' Employment Search

Every year thousands of college graduates seek employment. In preparing for a career, many students turn to the Office of Career Services for assistance since it is a resource that they can use in their job searches as they navigate through an increasingly tight job market. Despite the obvious importance of Career Services in higher education, not enough is known about how these offices work and how they utilize the various resources available to them...

Cross-sectional association between anxiety disorders and work performance among U.S. adults

Background. Past research shows that anxiety disorders can impair work performance, but there are no national studies examining the relationship between anxiety disorder subtypes and low work performance. In a representative sample of employed US adults, we examined the association between low work performance and three types of anxiety disorders--generalized anxiety disorder (GAD), panic disorder (PD), and post-traumatic stress disorder (PTSD). Methods. We analyzed data collected in 2001-2003 on 4,418 employed US adults participating in...

SYNTHESIS AND FUNCTIONALIZATION OF 1,4-POLYKETONES AND ENANTIOSELECTIVE POLYESTER CATALYST DEVELOPMENT USING MOLECULAR LEGO SCAFFOLDS

Objectives of the present study are aimed towards improving upon alternating copolymerization techniques for polyketones and aliphatic polyesters, and the majority of this work is focuses on post-polymerization modifications to alternating polyketones. These materials are currently under studied in the literature, but the aptly spaced, repeating carbonyl functionality creates an easily functionalized material. Complimentary work described herein relates to efforts currently underway to prepare highly enantioselective catalysts for the alternating copolymerization of epoxides with cyclic...

Understanding the academic literacy experiences of adult undergraduate students at a four-year public institution

Adult undergraduate students (age 25 or older) now make up 28% of the undergraduate student population at four-year public institutions. Using a sociocultural perspective of literacy, which posits that literacy and language are inextricably tied to identity, this qualitative multiple case study explores the adult undergraduate student experience with academic literacies: the specific languages of the university, both of its culture as a whole and the academic disciplines. Additionally, this study examines how the out-of-school...

MAYA POLITICAL ORGANIZATION DURING THE TERMINAL CLASSIC PERIOD IN THE COCHUAH REGION, QUINTANA ROO, MEXICO, FROM THE PERSPECTIVE OF A SECONDARY SITE

The dissertation examines the political organization of the ancient Maya during the Terminal Classic Period in the Cochuah Region of Quintana Roo. It evaluates the architecture and site layout of the secondary sites of Sacalaca and San Felipe, and tertiary and quaternary sites surrounding them in order to test political models. Our understanding of the ancient Maya political organization largely comes from Classic Period hieroglyphic texts recorded by Maya kings on public monuments. This reliance...

Improvement of Gastroparesis Management By Addressing Challenges in Drug Metabolism: Studies with Metabolite Identification, Reaction Phenotyping and In Vitro Drug-Drug Interactions

Gastroparesis is a disorder characterized by delayed gastric emptying due to chronic abnormal gastric motility. Prokinetic agents such as domperidone and metoclopramide are the cornerstone in treatment of gastroparesis. Although these medications have been used for decades, essential information about their metabolism is not available. Lack of knowledge about the metabolites formed in the body upon administration of the aforementioned medications as well as the enzymes involved in their metabolism limits key information needed to...

American Ignominy: The Incarceration of the Mentally Ill

Prisons and jails have become the de facto psychiatric hospitals of the twenty-first century. In the wake of deinstitutionalization, as mental healthcare transitioned to a community-based model, many patients with mental illness found themselves incarcerated rather than hospitalized. Strict drug laws combined with the current opioid epidemic are now forcing the government to consider treatment over punishment, lest the prison populations continue to swell. It is time to strongly consider using the involuntary commitment for...

Without words: The use of an image-based instructional video to convey information to culturally diverse audiences

The purpose of this project was to create a rubric from which researchers and filmmakers can begin producing media different from the existing English language, jargon-laden, instructional videos currently in use in the United States. From this rubric, one video detailing a clinic visit was produced, screened for a diverse audience and evaluated for its efficacy. This video utilized only images to convey information in an attempt to circumvent the confusion that may result while...

THE CHARACTERIZATION OF HSA-MIR148A IN HEPATOCARCINOGENESIS

Chronic Hepatitis B Virus (HBV) infection is a global health problem because of its connection to acute and chronic liver diseases as well as hepatocellular carcinoma (HCC). There is increasing evidence showing that HBV contributes to HCC due to persistently high levels of trans-activating protein---hepatitis B encoded x antigen (HBxAg). Studies have shown that the HBxAg affects and alters the activity of many different transcription factors and plays an essential role in several cytoplasmic signaling...

STAT2 in the regulation of tumor growth and antitumor effects of type I interferons in a mouse model of melanoma

Signal Transducer and Activator of Transcription (STAT) 2 is one of seven members of the STAT family of transcription factors with dual roles in signal transduction and gene activation. STAT2 is a central transcription factor that regulates the antiviral, apoptotic and cell growth inhibitory effects of type I interferons (IFN-α/β), a small family of secreted glycoproteins induced by the host after sensing the presence of tumor cells and pathogens. The creation of Stat2-/- mice established...

Climate Change Adaptation and Policy in Pacific Small Island States: Safe Havens or Adrift at Sea?

Pacific Small Island States (PSIS) are in the precarious position as some of the first jurisdictions to grapple with the current and forecasted effects of climate change, such as forced migrations and loss of culture. Yet, islanders' viewpoints are neither often fully understood nor heeded by those at the international decision making levels. Therefore, how and to what extent are PSIS successfully preparing for climate change? This completed study used a mixed methods approach that...

Growing Pains: Quaker Benevolence and School Expansion in Philadelphia's Educational Marketplace, 1730-1780

This essay examines the dynamics of Quaker school expansion in Philadelphia during the eighteenth century. The author argues that both administrators and teachers approached education as a competitive market, which influenced their decisions about hiring, student enrollment, and curriculum. However, Quaker ideas about benevolence also influenced and complicated their understanding of the educational marketplace.

Feeding, Dark Survival, and Foreign Organelle Retention in an Antarctic Dinoflagellate

The retention by protists of foreign plastids and other organelles obtained from algal prey is an ecologically important example of mixotrophy and also represents a potential pathway for the symbiogenetic evolution of novel permanent plastids. A gymnodinoid dinoflagellate isolated from the Ross Sea, Antarctica (RSD) retains plastids from its haptophyte prey Phaeocystis antarctica. It is a member of the Kareniaceae, a dinoflagellate family whose other members all contain permanent tertiary plastids of haptophyte origin. A...

Understanding the Dynamic Nature of Willingness to Communicate in L2 Classroom Interaction and the Influence of L2 Investment

In the context of language instruction and learning, L2 willingness to communicate (WTC) is a relevant factor in learners’ language use. It is viewed as a volitional process influenced by individual, social, linguistic, and situationally dependent factors. Foundational research focuses on either trait or state WTC-influencing factors as separate entities. Current research considers the dynamic relationship that occurs between the two though less research exists on how WTC manifests in classroom interaction. This study investigates...

TEACHING ADOLESCENTS WITH AUTISM TO ORDER IN A FAST FOOD RESTAURANT USING LEAST TO MOST PROMPTING

This study examined the effects of using least to most prompting to teach individuals with autism spectrum disorder (ASD) and intellectual disability to order independently at a fast food restaurant. Baseline data were collected across three fast food restaurants, on steps completed independently of a task analysis. Following the baseline phase, training was conducted in all three restaurants until students reached mastery criterion. Probe data were collected on percent of steps of the task analysis...

INTERFACIAL ENGINEERING OF SYNTHETIC AMPHIPHILES AND ITS IMPACT IN THE DESIGN OF EFFICIENT GENE AND DRUG DELIVERY SYSTEMS

Cancer is currently the second most common cause of death in the world. Despite tremendous progress in the treatment of different forms of cancer, the five year survival rates for lung, colorectal, breast, prostate, pancreatic and ovarian cancers remain quite low. New therapies are urgently needed for the better management of these diseases. In this context, both therapeutic gene and drug delivery constitute promising approaches for cancer treatment and are addressed in this thesis. Focusing...

LONGITUDINAL SOLUTE TRANSPORT IN OPEN-CHANNEL FLOW - A Numerical Simulation Study on Longitudinal Dispersion, Surface Storage Effects, Transverse Mixing, Uncertainties and Parameter-Transferring Problems

The longitudinal solute transport modeling is critical in river and stream water quality management, control, and the mitigation of hazardous riverine spills. One of the widely used "deadzone" model is the transient storage model (TSM). TSM is a significant improvement over the advection-dispersion model (ADM), but it cannot simulate the breakthrough curve (BTC) immediately after a large pool. Additionally, the calibration (parameterization) method is challenged by the non-identifiability which is common to all inverse modeling,...

A Good Death

While death is surely inevitable, the timing and circumstances of our deaths may vary widely and are likely to be negotiable in response to the changing needs of patients and families for physical, emotional and spiritual support as their diseases and illnesses evolve. Patients and families need to become aware of specific care options and supports that are available for them so they can be accessed in order to achieve their own “good death”. The...

DEVELOPMENT OF MAGNETO-OPTIC SENSORS WITH GALLIUM IN BISMUTH DOPED RARE-EARTH IRON-GARNET THICK FILMS

We have investigated the Faraday effect of bismuth-doped rare-earth iron-garnets with varying doping levels of gallium from z = 1.0 to 1.35. We used lutetium to control the film's in-plane magnetic properties and found that gallium doping levels above the compensation point caused a loss of anisotropy control, a canted out-of-plane magnetization in the film, and an extremely weak but linear coercivity above 10 micro-Tesla fields. Using these results we focused on in-plane films to...

Graph and Subspace Learning for Domain Adaptation

In many practical problems, given that the instances in the training and test may be drawn from different distributions, traditional supervised learning can not achieve good performance on the new domain. Domain adaptation algorithms are therefore designed to bridge the distribution gap between training (source) data and test (target) data. In this thesis, I propose two graph learning and two subspace learning methods for domain adaptation. Graph learning methods use a graph to model pairwise...

Registration Year

  • 2020
    4,583

Resource Types

  • Collection
    4,150
  • Text
    428
  • Image
    3
  • Dataset
    2