Isoform-and paralog-switching in IR-signaling: When diabetes opens the gates to cancer

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Insulin receptor (IR) and IR-related signaling defects have been shown to trigger insulin-resistance in insulin-dependent cells and ultimately to give rise to type 2 diabetes in mammalian organisms. IR expression is ubiquitous in mammalian tissues, and its over-expression is also a common finding in cancerous cells. This latter finding has been shown to associate with both a relative and absolute increase in IR isoform-A (IR-A) expression,...

A Hydrogel-Based Ultrasonic Backscattering Wireless Biochemical Sensing

© Copyright © 2020 Nam, Byun, Shim, Kim, Islam, Park, Kim and Song. Wireless monitoring of the physio-biochemical information is becoming increasingly important for healthcare. In this work, we present a proof-of-concept hydrogel-based wireless biochemical sensing scheme utilizing ultrasound. The sensing system utilizes silica-nanoparticle embedded hydrogel deposited on a thin glass substrate, which presents two prominent interfaces for ultrasonic backscattering (tissue/glass and hydrogel/glass). To overcome the effect of the varying acoustic properties of the intervening...

Cement Embolism Search Strategies

Contains the complete search strategies and the deduplicated database citations related to cement embolism.

Cosmogenic neutron production at Daya Bay

Neutrons produced by cosmic ray muons are an important background for underground experiments studying neutrino oscillations, neutrinoless double beta decay, dark matter, and other rare-event signals. A measurement of the neutron yield in the three different experimental halls of the Daya Bay Reactor Neutrino Experiment at varying depth is reported. The neutron yield in Daya Bay's liquid scintillator is measured to be $Y_n=(10.26\pm 0.86)\times 10^{-5}$, $(10.22\pm 0.87)\times 10^{-5}$, and $(17.03\pm 1.22)\times 10^{-5}~\mu^{-1}~$g$^{-1}~$cm$^2$ at depths of...

Progress in computing parton distribution functions from the quasi-PDF approach

© The Authors, published by EDP Sciences, 2018. We discuss the current developments by the European Twisted Mass Collaboration in extracting parton distribution functions from the quasi-PDF approach. We concentrate on the non-perturbative renormalization prescription recently developed by us, using the RI′ scheme. We show results for the renormalization functions of matrix elements needed for the computation of quasi-PDFs, including the conversion to the MS scheme, and for renormalized matrix elements. We discuss the systematic...

Structure-Aware Bayesian Compressive Sensing for Frequency-Hopping Spectrum Estimation with Missing Observations

© 1991-2012 IEEE. In this paper, we address the problem of spectrum estimation of multiple frequency-hopping (FH) signals in the presence of random missing observations. The signals are analyzed within the bilinear time-frequency (TF) representation framework, where a TF kernel is designed by exploiting the inherent FH signal structures. The designed kernel permits effective suppression of cross-terms and artifacts due to missing observations while preserving the FH signal autoterms. The kerneled results are represented in...

Observational study of coagulation activation in early breast cancer: Development of a prognostic model based on data from the real world setting

© 2018 The Author(s). Background: Cancer and coagulation activation are tightly related. The extent to which factors related to both these pathologic conditions concur to patient prognosis intensely animates the inherent research areas. The study herein presented aimed to the development of a tool for the assessment and stratification of risk of death and disease recurrence in early breast cancer. Methods: Between 2008 and 2010, two hundreds thirty-five (N: 235) patients diagnosed with stage I-IIA...

Active lifestyles in older adults: An integrated predictive model of physical activity and exercise

© Galli et al. Physical activity and exercise have been identified as behaviors to preserve physical and mental health in older adults. The aim of the present study was to test the Integrated Behavior Change model in exercise and physical activity behaviors. The study evaluated two different samples of older adults: the first engaged in exercise class, the second doing spontaneous physical activity. The key analyses relied on Variance-Based Structural Modeling, which were performed by...

Hyperhomocysteinemia potentiates diabetes-impaired EDHF-induced vascular relaxation: Role of insufficient hydrogen sulfide

© 2018 The Authors Insufficient hydrogen sulfide (H2S) has been implicated in Type 2 diabetic mellitus (T2DM) and hyperhomocysteinemia (HHcy)-related cardiovascular complications. We investigated the role of H2S in T2DM and HHcy-induced endothelial dysfunction in small mesenteric artery (SMA) of db/db mice fed a high methionine (HM) diet. HM diet (8 weeks) induced HHcy in both T2DM db/db mice and non-diabetic db/+ mice (total plasma Hcy: 48.4 and 31.3 µM, respectively), and aggravated the impaired...

Social status modulating chronic stress: Social rank differentially influences how male and female mice respond to chronic stress.

Social rank differentially influences how male and female mice respond to chronic stress.

Type II secretion-dependent aminopeptidase lapa and acyltransferase plac are redundant for nutrient acquisition during Legionella pneumophila intracellular infection of amoebas

© 2018 White et al. Legionella pneumophila genes encoding LapA, LapB, and PlaC were identified as the most highly upregulated type II secretion (T2S) genes during infection of Acanthamoeba castellanii, although these genes had been considered dispensable on the basis of the behavior of mutants lacking either lapA and lapB or plaC. A plaC mutant showed even higher levels of lapA and lapB transcripts, and a lapA lapB mutant showed heightening of plaC mRNA levels,...

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

© 2018 The Author(s). Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference sets. We apply this framework to 44 GTEx tissues and 100+ phenotypes from GWAS and meta-analysis studies, creating a growing public catalog of associations that seeks to capture the...

Strange nucleon electromagnetic form factors from lattice QCD

© 2018 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the »https://creativecommons.org/licenses/by/4.0/» Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. We evaluate the strange nucleon electromagnetic form factors using an ensemble of gauge configurations generated with two degenerate maximally twisted mass clover-improved fermions with mass tuned to approximately...

Systemic inflammatory status predict the outcome of k-RAS WT metastatic colorectal cancer patients receiving the thymidylate synthase poly-epitope-peptide anticancer vaccine

© Correale et al. TSPP is an anticancer poly-epitope peptide vaccine to thymidylate synthase, recently investigated in the multi-arm phase Ib TSPP/VAC1 trial. TSPP vaccination induced immune-biological effects and showed antitumor activity in metastatic colorectal cancer (mCRC) patients and other malignancies. Progression-free and overall survival of 41 mCRC patients enrolled in the study correlated with baseline levels of CEA, immune-inflammatory markers (neutrophil/lymphocyte ratio, CRP, ESR, LDH, ENA), IL-4 and with post-treatment change in p-ANCA and...

Baseline neutrophilia, derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), and outcome in non small cell lung cancer (NSCLC) treated with Nivolumab or Docetaxel

© 2018 The Authors. Journal of Cellular Physiology Published by WileyPeriodicals, Inc. Nivolumab is a novel therapeutic option in NSCLC, associated with a significant survival gain compared with Docetaxel. However, predictive biomarkers are lacking. The presence of systemic inflammation has been correlated with poor outcome in many cancer types. We aimed to evaluate whether there is a correlation between some indicators of inflammation and response to Nivolumab or Docetaxel in pre-treated NSCLCs. Data of 62...

Analysis of a conditional gene trap reveals that tbx5a is required for heart regeneration in zebrafish

© 2018 Grajevskaja et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The ability to conditionally inactivate genes is instrumental for fine genetic analysis of all biological processes, but is especially important for studies of biological events, such as regeneration, which occur late in ontogenesis or in adult...

First-principles study of the binding energy between nanostructures and its scaling with system size

© 2018 American Physical Society. The equilibrium van der Waals binding energy is an important factor in the design of materials and devices. However, it presents great computational challenges for materials built up from nanostructures. Here we investigate the binding-energy scaling behavior from first-principles calculations. We show that the equilibrium binding energy per atom between identical nanostructures can scale up or down with nanostructure size, but can be parametrized for large N with an analytical...

Will virtual rehabilitation replace clinicians: a contemporary debate about technological versus human obsolescence

© 2020, The Author(s). This article is inspired by a pseudo Oxford-style debate, which was held in Tel Aviv University, Israel at the International Conference on Virtual Rehabilitation (ICVR) 2019, which is the official conference of the International Society for Virtual Rehabilitation. The debate, between two 2-person teams with a moderator, was organized by the ICVR Program committee to address the question “Will virtual rehabilitation replace clinicians?” It brought together five academics with technical, research,...

Peer Victimization Predicts Neural Response to Simulated Social Feedback from Peers

Peer victimization has been found to relate to internalizing problems, including depression and anxiety (Reijntjes et al., 2010). Research has also shown that peer victimization relates to neural response to social feedback, such as increased activation in the dorsal anterior cingulate cortex and anterior prefrontal cortex to social exclusion (Rudolph et al., 2016; Will et al., 2015). The current study aims to examine the impact of peer victimization on neural response to social feedback using...

High-Achieving Low-Income High School Students and their Awareness and Perceptions of Acceptance to Top-Tier Universities

The purpose of this study is to determine specific barriers that prevent students in a high-achieving low-income (HALI) school from applying to selective colleges and universities. Currently, there is a drastically lower number of HALI students applying to the most selective higher education institutions (HEIs) in the United States in comparison to their equally academically successful high income peers. Prior research has shown that there are many known barriers that hinder HALI students from submitting...

Talk Rocks: A Field Guide to Creative Writing

The intersections of geoscience and creative writing cannot be ignored when it comes to modern education. Although it may not be intuitive, geoscientists can take advantage of creative writing techniques in order to make information about science more accessible to the public. This work compiles communication techniques that might serve scientists, provides examples and prompts for scientists to practice their communication, and discusses the importance of inter-disciplinary collaboration.

Evaluation of Transcranial NIR Light Propagation for Photo-biomodulation of Neurons Using Mesh-Based Monte Carlo Modeling

Research has shown that photo-biomodulation of neurons with near-infrared (NIR) light can stimulate their regeneration, and thus various research groups have developed devices that emit NIR light transcranially (through the skull) to stimulate neural growth in the brain in an effort to treat neurological diseases such as Multiple Sclerosis (MS) and Alzheimer’s. However, it is not clear that clinical device designs illuminate cells in the brain with similar parameters as those shown effective for neuro-regeneration...

Home-based neurologic music therapy for arm hemiparesis following stroke: results from a pilot, feasibility randomized controlled trial

© 2017, © The Author(s) 2017. Objective: To assess the feasibility of a randomized controlled trial to evaluate music therapy as a home-based intervention for arm hemiparesis in stroke. Design: A pilot feasibility randomized controlled trial, with cross-over design. Randomization by statistician using computer-generated, random numbers concealed in opaque envelopes. Setting: Participants’ homes across Cambridgeshire, UK. Subjects: Eleven people with stroke and arm hemiparesis, 3–60 months post stroke, following discharge from community rehabilitation. Interventions: Each...

© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. Tyrosine phosphorylation is a common protein post-translational modification that plays a critical role in signal transduction and the regulation of many cellular processes. Using a propeptide strategy to increase cellular uptake of O-phosphotyrosine (pTyr) and its nonhydrolyzable analog 4-phosphomethyl-L-phenylalanine (Pmp), we identified an orthogonal aminoacyl-tRNA synthetase-tRNA pair that allows site-specific incorporation of both pTyr and Pmp into recombinant proteins in response to the...

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