1,640 Works

Novel genetic effects of a human endogenous retrovirus insertion

Paul Edward Kowalski
Human endogenous retroviruses (HERVs) are repetitive, noninfectious chromosomal elements degenerated from exogenous retroviruses, and compose as much as 2% of the human genome. The HERV-H family numbers approximately 1000 elements dispersed throughout the human genome. HERV-H elements have been shown to affect the expression of adjacent cellular genes. For example, in teratocarcinoma cell lines, a HERV-H LTR promotes expression of, and splices into a downstream cellular transcript, PLA2L, which contains two phospholipase A₂ (PLA₂)-like domains....

Putting the cart behind the horse : using interface driven modeling to help regional stakeholders craft an understanding of sustainability

Michael Dennis Walsh
This thesis examines the theoretical underpinnings of an innovative approach used in developing a computer based educational tool. The tool itself combines two fundamental design philosophies from a previous modeling and scenario building exercise with an urgent need to more effectively engage regional stakeholders in the complexities and intricacies of sustainability. The result is a powerful learning tool aimed at stimulating dialogue and increasing understanding about regional growth and development issues. In order for this...

Genetically-engineered populus hybrids and metalliferous soil remediation

Monica A. Schmidt
With global heavy metal pollution increasing, there is a need for innovative metal decontamination processes. Plants that have the ability to sequester metal contaminants within their tissues promise to be a cost-effective soil remediation practice. A poplar hybrid clone, Populus alba x P.tremula (INRA clone 717-1B4), was selected for this soil metal remediation research due to its large biomass and extensive deep tap root system that enables it to encounter many contaminants within its surroundings....

Neutrophil elastase gene expression in health and disease

Edmond Tan-Loon Wong
Neutrophil elastase (NE) is a major protease carried by neutrophils and synthesized in the promyelocyte. A role of NE in the pathogenesis of emphysema was hypothesized over 25 years ago. Our understanding of the pathogenesis of this disease has remained obscure however, due to the lack of an accurate model for examining the causative role of proteases such as NE in the disease. The hypothesis is presented that over-expression of NE increases susceptibility to emphysema....

Cross cultural collaboration and community art practice : an autobiographical examination

Amirali B. Alibhai
A thesis is presented that utilizes phenomenological and hermeneutic methodology to explore the notion of cross-cultural collaboration and community art practice. I examine Witness, a substantive cross-cultural collaboration with First Nations, and my own practice as a cultural worker in describing denning elements of successful cross-cultural collaboration. In a final "meta-chapter", Community art practice is characterized as a contemporary cultural phenomenon, located at the forefront of cultural practice.

Investigating the survivability of an ecological, family-centered positive behaviour intervention with a family of a child with a developmental disability and problem behaviour

Stephen Chinn
The purpose of this study was to replicate the work of Lucyshyn et al. (2011) and Binnendyk (2009) by investigating the survivability of an intervention based upon an ecological, family-centered positive behaviour support approach to assessment and intervention. The approach integrates child behaviour, parent-child interaction, and family activity settings into an ecological unit of analysis aimed at improving child behaviour, parent-child relationships, and promoting meaningful changes in the functioning of the family. One family of...

Criteria-based content analysis : an experimental investigation with children

Risha D. Joffe
The aim of the present study was to experimentally test the Undeutsch Hypothesis, which holds that children's statements based on self-experienced events are qualitatively and quantitatively different from statements based on coaching. Specifically, this study tested the validity of Criteria-Based Content Analysis (CBCA, a system for assessing the credibility of eyewitness reports) for discriminating between credible and non credible eyewitness reports by children. As well, two other tests of the quantitative and qualitative differences between...

Passing the buck: federalism and Canadian environmental policy

Kathryn J. Harrison
This thesis examines how the current division of federal and provincial responsibilities for environmental policy in Canada evolved, and the implications of that arrangement for protection of the environment. At a theoretical level, the example of environmental protection is used to explore the relationship between federalism and public policy more generally. It is accepted wisdom that governments seek both to claim credit and avoid blame. However, to date, students of Canadian federalism have been much...

Three essays in real estate economics

Yuming Fu
This dissertation consists of three separate essays. The first two essays focus on real estate brokerage; one studies the conditions for efficient employment in the real estate brokerage industry under fixed commission rates and the other examines the role of real estate agents in buyer-seller bargaining. The third essay presents an integrated analysis of housing investment and consumption choices that takes into account both the uncertainty in investment returns and liquidity constraints. Essay one presents...

Consuming visions : pop art, mass culture, and the American dream, 1962-65

Sandra Elizabeth Gillespie
Between 1962 and 1965 pop art received a phenomenal amount of exposure in mass-market magazines such as Time, Life, Esquire, Ladies Home Journal, Business Week, House and Garden and Reader's Digest. While coverage of art in non-art publications was in itself not unusual, the rapidity, prevalence, extensiveness, and ambiguity of pop coverage were unique. In the writings of most pop art historians this phenomenon is either overlooked or explained away as yet another instance of...

Studies with tissue cultures of tripterygium wilfordii. Isolation of metabolites and biotransformation studies

Malcolm Roberts
In a program aimed at the identification of compounds responsible for the immunosuppressive and antifertility activities of the perennial twining vine, Tripterygium wilfordii. 5 new and 13 known compounds were isolated from the TRP-4a tissue culture cell line developed from Tripterygium wilfordii. The structures of the new compounds were determined by a combination of spectral analysis, chemical correlation and single crystal X-ray diffraction analysis. 22β-Hydroxy-3-oxoolean-12-en-29-oic acid (137), 22α-hydroxy-3-oxoolean- 12- en-29-oic acid (138) and 3β, 22β-dihydroxyolean-12-en-29-oic...

Multilayer beam analysis including shear and geometric nonlinear effects

Herman Ho Ming Kwan
This thesis presents an analysis and experimental verification for a multilayer beam in bending. The formulation of the theoretical analysis includes the combined effect of shear and geometric nonlinearity. From this formulation, a finite element program (CUBES) is developed. The experimental tests were done on multilayer, corrugated paper beams. Failure deflections and loads are thus obtained. The experimental results are reasonably predicted by the numerical results. Based upon this comparison, a maximum compressive stress is...

The regulation of numbers in Tribolium confusum by means of selective migration

Ernest A Carl
A lengthy, and at times heated, debate on the regulation of animal numbers has proceeded in the literature for over half a century. A wide variety of causal agents - from sun spots to a shortage of trace elements - has been proposed to explain the observed densities, and a wide variety of mechanisms has also been proposed - from natural selection to chance. Only occasionally have any of these proposals been rigorously tested, and...

Environment and the quest motif in selected works of Canadian prairie fiction

Linda Rogers
Time and place are the media through which the eternal is manifested for the comprehension of fallible man. It is the response to environment which has determined and shaped the human attitude toward ultimate mysteries. The patterns of nature are translated by the artist and philosopher into the ritual behaviour of man. The challenge of adversity and the joy of the morning or the new season are motivation for the restless desire to overcome the...

The relationship of individual anaerobic thresholds to total, alactic, and lactic oxygen debts after a set treadmill run

James Preston Wiley
Anaerobic threshold speed (VTAM) was determined for 20 male university students using a continuous treadmill protocol. The onset of anaerobiosis was determined by analyzing excess CO₂ elimination. The following week, all subjects ran at the VTAM median speed of 7.25 miles per hour for 10 minutes. Recovery oxygen consumption was monitored after this run. Application of double exponential equations by computer and subsequent integration, calculated Total, Alactic, and Lactic Oxygen Debts. Subjects who ran above...

Electronic versus mechanical loading in the determination of peak oxygen consumption in bicycle ergometry

Mark Anthony Clarke
The purpose of the study was to determine if differences in the loading (or braking) systems of two different types of stationary bicycle ergometers (Monark and Dynavit models) influenced the performances of subjects in similar submaximal and maximal exercise. A maximal treadmill test, also performed by the subjects, was used as a criterion measure with which the maximal bicycle ergometer test results were compared. The possibility of finding differences in the performances of subjects on...

Variable X inactivation of the human TIMP1 gene

Catherine Linda Anderson
X inactivation silences most of the genes on one of the two X chromosomes in mammalian females, presumably to achieve dosage compensation of X-linked gene products. The human X chromosome preserves its activation status when isolated in rodent/human somatic cell hybrids. Surprisingly, the human tissue inhibitor of metalloproteinases-1 gene (TIMP1) is expressed in some but not all inactive Xcontaining hybrids, suggesting that this gene is either prone to reactivation or variable in its inactivation. Although...

The association between deceptive motivations and personality disorders in male offenders

Alicia Spidel
The detection of deception is an integral part of any forensic assessment. Unfortunately, the motives underlying the use of deceptive strategies by offenders and how these may differ between different types of personality-disordered offenders are not well established. The aim of the present study was to identify different deception-related motivations in a sample of offenders and to examine the relationship between these motivations and personality pathology. Archived file and videotaped information for 103 Canadian federal...

Detection and characterization of human mammary stem cells

Peter Eirew
The mammary gland of adult female mice contains undifferentiated epithelial stem cells with in vivo regenerative and self-renewal properties. A biologically similar population likely exists in the human breast but a specific and quantitative methodology to identify and characterize these cells has been lacking. In this study I show that human mammary structures are reproducibly generated when dissociated suspensions of primary human mammary cells are propagated in collagen gels that have been implanted under the...

Neurobiological correlates of overweight and obesity in people with bipolar disorder

David Joseph Bond
Up to 75% of people with bipolar disorder (BD) are overweight or obese, and these patients suffer more severe psychiatric symptoms than normal-weight patients, including more frequent depressions, more suicide attempts, lower response rates to pharmacotherapy, and greater cognitive impairment. Obesity is a chronic inflammatory condition that damages numerous body organs and is causally linked to the development of diabetes, heart disease, and cancer. BD is fundamentally a brain illness, and this, along with converging...

Unsolicited narratives from cancer survivors : a longitudinal, qualitative analysis

Candace Marshall
Being diagnosed with the ‘C’ word, also known as cancer, provokes a wide variety of psychological reactions for those newly diagnosed with the disease. The cannon of literature on how individuals cope and adjust to a cancer is diverse and suggests that how one copes and adjusts is influenced by such variables as age, gender, social support, cancer severity and cancer type. This qualitative study is a secondary analysis of unsolicited narratives written in the...

The function of protein tyrosine phosphatase alpha (PTPα) phosphorylation in integrin-mediated signaling

Suzanne Yuen Shan Cheng
The integrin signaling network involves over 180 components and regulates a wide range of biological activities including cell adhesion, survival and migration. However, the details of the molecular mechanisms that govern these cellular processes remain unclear. Since defective integrin signaling is often associated with diseases such as cancer, a precise understanding of the molecular mechanisms underlying integrin-mediated processes may provide novel insights for developing therapeutics against cancer. Protein tyrosine phosphatase alpha (PTPα) is a receptor-like...

A neurobehavioral investigation of orienting behavior

Glenda C. Midgley
Models of the neural basis of visually guided behavior suggest that the mammalian brain has two independent visual systems: one involved in pattern vision, and the other involved in orienting to visual stimuli. Orienting was measured in this series of studies by examining both the thirsty rat's ability to disrupt licking in response to the presentation of visual and auditory displays and the animal's head and postural responses to the displays. Habituation of orienting behavior...

Nurses' perspectives of parental participation in the care of preterm infants in a special care nursery

Norma Foster
Nurses in neonatal special care nurseries with a philosophy of family centered care involve parents in the care of preterm infants. There is little research describing nurses' perspectives of parental participation in care. Using interview data obtained from one secondary level neonatal special care nursery, this study attempts to understand the meaning parental participation in care has for neonatal nurses and the way that meaning is expressed in various nursing activities. Twelve nurses were interviewed...

Coordination of transportation and land use planning : a case study of Greater Vancouver

Reginald Paul Faubert
The purpose of this thesis is to examine the coordination between transportation and other aspects of land use planning. This purpose is achieved through studying transportation planning and decision making in light of general overall metropolitan planning. Transportation planning is defined as a process for addressing societal concerns while attempting to meet the demands for transport made by the populace. Decision making is the final result of this process. In developing a model of the...

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