### CHARACTERIZATION AND USE OF PATHOGEN SPECIFIC BACTERIOPHAGES TO REDUCE THE VIABILITY OF Escherichia coli O157:H7 CONTAMINATION ON FRESH PRODUCE

Fresh produce is one of the most common sources of food-borne outbreaks, involving various pathogenic microorganisms such as Escherichia coli. Recent outbreaks have clearly shown that post-harvest washing has limited effectiveness on decontaminating produce and may contribute to cross-contamination of produce due to various limitations. Excessive use of sanitizers and antibiotics has also led to the development of many antibiotic-resistant strains of bacteria that have made the food industry more vulnerable. Bacteriophages are a bacterial...

### Conversation Goals, Communication Satisfaction, and Relational Dynamics While Navigating Alzheimer’s Disease

Elizabeth Spencer
Currently there are more than 16 million unpaid Alzheimer’s disease and dementia caregivers in the United States. These caregivers are often family members of the person living with dementia, and as they navigate the process of giving care to the patient, they must also maintain relationships with each other. Families enter the dementia experience with a history of their relational experiences, and their relational experiences potentially change as they navigate family experiences after the dementia...

### The Effects of Opioids on Kentucky's Workforce

Michael W. Clark, Jenny A. Minier, Charles Courtemanche, Bethany L. Paris & Michael T. Childress
Opioid abuse represents a significant and growing public health issue for both the nation and Kentucky. In 2016, opioids contributed to more than 62,000 deaths nationally and 1,406 deaths in Kentucky. National studies have placed the societal costs of opioid abuse at $55.7 billion in 2007 and$78.5 billion in 2013 (Birbaum et al. (2011) and Florence et al. (2016)). These costs included increased health care expenditures, higher criminal justice costs, and lost earnings due...

### Improving Kentucky's Winter Wheat and Double Crop Soybean Rotation

Katherine Rod
The winter wheat double crop soybean rotation is an economically viable rotation for Kentucky farmers. Recent decreases in commodity prices has warranted the need to evaluate intensive management practices that can increase yields and profitability in this crop rotation. There were three goals of this dissertation: 1.) identify management practices that would decrease deoxynivalenol (DON) in harvested wheat grain and increase wheat heading and anthesis uniformity, 2.) evaluate double crop soybean planting timing and identify...

### PSYCHOSOCIAL PREDICTORS OF CHRONIC PAIN AND PAIN-RELATED DISABILITY 12 MONTHS AFTER LOWER EXTREMITY FRACTURE

Joshua Van Wyngaarden
Over 700,000 lower extremity fractures occur each year with a large portion of these patients developing adverse long-term pain and disability outcomes. Current literature indicates that 39% to 62.7% of all patients report continued pain long after traumatic lower extremity fracture. Concurrent physical limitations and reduced quality of life are common, with nearly one-third of all patients reporting pain-related disability seven years after limb threatening trauma, and approximately 50% of these patients having limitations in...

### Applications of Drones in Atmospheric Chemistry

Travis Schuyler
The emission of greenhouse gases (GHGs) has changed the composition of the atmosphere during the Anthropocene. A major technical and scientific challenge is quantifying the resulting fugitive trace gas fluxes under variable meteorological conditions. Accurately documenting the sources and magnitude of GHGs emission is an important undertaking for discriminating contributions of different processes to radiative forcing. Therefore, the adverse environmental and health effects of undetected gas leaks motivates new methods of detecting, characterizing, and quantifying...

### IONIC BONDING CURRICULUM UNIT

Mary Lamar
This mixed methods study compared two groups of high school students’ understanding of the ionic bond and the dissolving process. A 5 lesson curriculum unit was developed using Taber’s electrostatic framework (1997) focusing on the electrostatic forces between ions compared to a molecular framework (business-as-usual) and the Next Generation Science Standards (NGSS Lead States, 2013). The lessons were developed to integrate spatially integrated experiences. Experimental (new curriculum unit) and business-as-usual (criss-cross method) students had their...

### CHARACTERIZATION AND ELECTROCHEMICAL PERFORMANCE OF DOPAMINE-SENSITIZED TITANIA THIN FILMS

Joshua Garay
Sensitization of mesoporous titania films with dopamine and polydopamine for visible light photoelectrochemical activity is investigated. Sensitization effectiveness is compared with 8 mM dopamine solutions of varying pH (acidic, basic, and neutral), as well as with a basic polydopamine solution. Vibrational changes due to dopamine attachment are determined from detached powders by Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA) is used to quantify organics attached. X-ray photoelectron spectroscopy (XPS) of intact films probes the...

### Two Analytical Essays

Abigail Rueger
These two essays address different issues regarding Lieder. Chapter 1 discusses moon topoi and traces the development of these topics from “naïve” in Gluck’s works to “sentimental” in the songs of Fanny Hensel, based on the philosophical ideas of Friedrich Schiller. Chapter 2 focuses on specific translation theory, drawing on work from Mona Baker and Zhang Qun-Xing, arguing that one cannot compare two song settings of different translations of the same poem, since the translator’s...

### VILLAGE-TEMPLE CONSCIOUSNESS IN TWO JAFFNA TAMIL VILLAGES IN POST-WAR SRI LANKA

Pathmanesan Sanmugeswaran
This dissertation investigates how community rebuilding is occurring in a gravely damaged, post-conflict society. Specifically, it looks at how people in two villages in Tamil, Hindu, Jaffna, Sri Lanka, are using their ‘sense of place’ and ‘place-making practices’ or what I call here their ‘village-temple consciousness’ or village consciousness, to maintain and rebuild their communities after war to make them, once again, places in which they feel a comfortable sense of belonging. This is a...

### Ab initio Investigation on the Surface Chemistry of Functionalized Titania Membranes

Evan Hyde
Titania (titanium dioxide) is a metal oxide which has recently been investigated as a photocatalyst, most commonly for use in hydrolysis, which absorbs mostly in the UV range. However, the range of absorption can be shifted to fall within the visible light range either by doping or by functionalizing the surface with atomic or molecular adsorbates. Over the course of this research, a series of Density Functional Theory (DFT) calculations are performed to ascertain the...

### Graph-Theoretic Simplicial Complexes, Hajos-type Constructions, and k-Matchings

Julianne Vega
A graph property is monotone if it is closed under the removal of edges and vertices. Given a graph G and a monotone graph property P, one can associate to the pair (G,P) a simplicial complex, which serves as a way to encode graph properties within faces of a topological space. We study these graph-theoretic simplicial complexes using combinatorial and topological approaches as a way to inform our understanding of the graphs and their properties....

### TRANSFORMATIVE SUBJECTS

Emily R. DeHaven
Through this dissertation, I explore the ways that authors and editors use the form of children’s periodicals to discuss questions of childhood independence, the structure of the family, and the balance of power between children and adults with regards to literary texts. I examine the ways in which adults and children negotiate control over the periodicals and over the images of transformation present within those texts. Periodicals offer a unique opportunity for interaction between readers...

### THE EFFECTS OF THREE SERVICE DELIVERY MODELS ON VOCABULARY LEARNING BY SECOND-GRADE CHILDREN

Laura Glastetter-Stone
Speech-Language Pathologists (SLPs) provide services to children in schools across the United States primarily in a direct small group service delivery model outside of the regular education classroom. To date little research exists to indicate that direct pull-out service delivery is an effective model in elementary schools for students requiring speech and language therapy. One area that has been studied is the effectiveness of vocabulary intervention among service delivery models. Preliminary findings suggest that students...

### A BIOPHYSICAL INVESTIGATION OF STABILITY, LIGAND BINDING, AND IRON STATE OF CYP102A1

Catherine Denning
Cytochrome P450s (CYPs) are cysteine ligated Fe-heme monooxygenases that are found in all domains of life. In mammals, they have a role in xenobiotic metabolism and steroid synthesis, making them a fundamental requirement for survival. In addition, their ability to perform a variety of chemical reactions on an array of substrates makes CYPs highly sought for biotechnical applications such as wastewater remediation, production of potential drug candidates, and creation of drug metabolites. By mutating specific...

### Fiscal Year 2011 FHWA-536 Report for the Kentucky Transportation Cabinet

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The Federal Highway Administration (FHWA) requires state transportation agencies to submit a biennial report on local highway finances. The purpose of these reports is to provide FHWA with the data it needs to capture the financing of highway activities at the local level. Based on this information, it can identify trends in revenue, expenditures, investments, and program development, and in turn make decisions about future investments. The report, FHWA-536, asks agencies to report on four...

### A MULTI-METHOD INVESTIGATION OF THE MODERN SEDIMENTATION AND LATE HOLOCENE PALEOLIMNOLOGY OF JUNE LAKE (MONO COUNTY, CA), AND A SURVEY-BASED ANALYSIS OF NINTH GRADERS’ ATTITUDES TOWARDS GEOLOGY

Eva Lyon
Three distinct manuscripts comprise this dissertation. The first analyzes the modern sedimentary basin of June Lake, a small glacial lake in the eastern Sierra Nevada of California (USA) using a number of data sets, including bathymetry, surface sediment composition, and seismic stratigraphy. The seismic survey revealed sublacustrine morphological features that suggest the basin originated due to ice scour, as well as four acoustically distinct stratigraphic units that reflect the history of sedimentation following glacial scouring....

### TOBACCO USE AND NICOTINE WITHDRAWAL AMONG PATIENTS WITH MENTAL ILLNESS

Yazan Al-Mrayat
People with mental illness (MI) are disproportionately affected by tobacco use compared to the general population. In fact, it is estimated that people with MI consume approximately 44% of cigarettes smoked in the United States. Moreover, the MI population is at greater risk for the negative social, economic, and health consequences associated with tobacco use and are reported to have 25-year shorter life expectancies than the general population. The impact of tobacco use is further...

### HIGH FREQUENCY OSCILLATIONS IN THE EPILEPTIC BRAIN

AMIR AL-BAKRI
About a third of all epilepsy patients may experience seizures that are resistant to medication. Surgical resection may be an option for some of these patients, but localization of the epileptogenic zone is difficult and expensive. For this process, the seizures must be observed and recorded in a clinical setting over several days. High-frequency oscillations (HFOs) have emerged as a possible biomarker for predicting the epileptogenic zone from a brief interictal recording of brain electrical...

### THE INFLUENCE OF CRYOGENIC MACHINING ON SURFACE INTEGRITY AND FUNCTIONAL PERFORMANCE OF TITANIUM ALLOYS FOR BIOMEDICAL AND AEROSPACE APPLICATIONS

Ying Sun
The excellent properties of titanium alloys such as high strength, as well as good corrosion and fatigue resistance are desirable for the biomedical and aerospace industry. However, the same properties that make titanium alloys desirable in high-performance applications also make these space-age materials “difficult-to-machine” materials, as the titanium alloys exhibit high cutting temperatures because of their high strength and low thermal conductivity. Cryogenic machining is a severe plastic deformation (SPD) processes which uses liquid nitrogen...

### INVESTIGATION INTO MINE PILLAR DESIGN AND GLOBAL STABILITY USING THE GROUND REACTION CURVE CONCEPT

Ravi Chandan Ray
Pillars form an important support structure in any underground mine. A bulk of the overburden load is borne by the mine pillars. Thus, the strength of pillars has been a subject of detailed research over more than 6 decades. This work has led to the development of largely empirical pillar design formulations that have reduced the risk of pillar failures and mine collapse. Current research, however, has drawn attention to the fact that some of...

### RESIDENTIAL RADON EXPOSURE, ITS CONTRIBUTION TO LUNG CANCER, AND SOCIAL DETERMINANTS OF RADON TESTING

Stacy Stanifer
Lung cancer is a highly preventable form of cancer. Cigarette smoking is the leading cause of lung cancer followed by radon gas exposure and exposure to secondhand smoke. Kentucky leads the nation in both incidence and mortality from lung cancer. Tobacco use in Kentucky continues to be a major public health concern as nearly one-quarter of adults report current tobacco use and just over one-third of Kentucky homes with children lack rules which prohibit smoking...

### POPULATION PHARMACOKINETIC MODELING AND GENETIC ASSOCIATION ANALYSIS IN INFANTS WITH NEONATAL ABSTINENCE SYNDROME RECEIVING MORPHINE OR CLONIDINE

Fei Tang
Neonatal abstinence syndrome, or NAS, is a postnatal opioid withdrawal syndrome occurring in 55% to 94% of neonates as a result of in utero exposure to opioids. It has emerged as a significant public health issue, as its incidence more than quadrupled in the past decade. There is significant variability in disease severity and treatment outcomes in neonates with NAS due to patient-specific factors and treatment- or site-specific factors. To understand what contributes to variability...

### LASER ABLATION IN LIQUID FOR THE CONTROLLED PRODUCTION OF PHOTOLUMINESCENT GRAPHENE QUANTUM DOTS AND UPCONVERTING NANOPARTICLES

Rosemary Calabro
Photoluminescent­ (PL) nanomaterials play an important role in areas including displays, sensing, solar, photocatalysis, and bio applications. Traditional methods to prepare PL materials suffer many drawbacks such as harsh chemical precursors, complicated synthetic steps, and production of many byproducts. Laser ablation in liquid (LAL) has emerged as a promising alternative to prepare materials that is single-step, fast, uses fewer precursors, produces fewer side products, and has simple purification steps. During LAL, a solid target is...

### COARSE-GRAINED DYNAMICALLY ACCURATE SIMULATIONS OF IONIC LIQUIDS AT VACUUM-INTERFACE

Tyler Stoffel
Ionic liquids, possessing improved properties in many areas of technical application, are excellent candidates as components in development of next-generation technology, including ultra-high energy batteries. If they are thus applied, however, extensive interfacial analysis of any selected ionic configuration will likely be required. Molecular dynamics (MD) provides an advantageous route by which this may be accomplished, but can fall short in observing some phenomena only present at larger time/length scales than it can simulate. Often...

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#### Affiliations

• University of Kentucky
597
• University of California, San Diego
4
• National Institutes of Health
3