912 Works

The Revolt Against Mourning

Andrew Leo Beutel
The Revolt against Mourning calls into question the widespread critical alignment of literary modernism with Freudian melancholia. Focusing instead on “mourning,” through close readings of Virginia Woolf’s Mrs. Dalloway, James Joyce’s Ulysses, and William Faulkner’s The Sound and the Fury, I demonstrate how their depictions of this notion overturn both its traditional and contemporary understandings. Whereas Freud conceives mourning as a psychic labor that the subject slowly and painfully carries out, Woolf, Joyce, and Faulkner...

Effects of Abiotic Stresses on Sorbitol and Ribitol Accumulation and Sorbitol Biosynthesis and Metabolism in Tomato [Solanum lycopersicum L.]

Afaf Almaghamsi
Abiotic stresses are responsible for limiting crop production worldwide. Among diverse abiotic stresses, drought and salinity are the most challenging. Plants under these conditions have diverse strategies for tolerating stress. Osmotic adjustment and osmoprotection occur in plants during salinity and drought stress through accumulation of compatible solutes to a high level without interfering with cellular metabolism. Polyols (sugar alcohols) including sorbitol and ribitol are one such class of compatible solutes. Using plants of wild-type (WT)...

Functionalization of Iron Oxide Nanoparticles and the Impact on Surface Reactive Oxygen Species Generation for Potential Biomedical and Environmental Applications

Trang Mai
Iron oxide nanoparticles (IONPs) have been widely studied for a variety of applications, from biomedical applications (e.g., cell separation, drug delivery, contrast agent for magnetic resonance imaging and magnetically mediated energy delivery for cancer treatment) to environmental remediations (e.g., heavy metal removal and organic pollutants degradation). It has been demonstrated that IONPs can induce the production of reactive oxygen species (ROS) via Fenton/Haber-Weiss reactions which has been shown to be one of the key underlying...

Two Essays on Input Substitution and Optimal Decision Making in Crop and Livestock Production Systems

John T., Jr. Allison
The thesis presented consists of two essays that analyze input substitution and decision making in crop and livestock production systems. The first essay consists of a whole-farm analysis that sought to optimize feed mixes and enterprise combinations for an organic dairy operation in the Southeastern United States. This was accomplished through mathematical programming where whole-farm net returns were maximized, and total feed costs were minimized simultaneously for four milk production level cases. Additionally, the sensitivity...

Computational Tools for the Dynamic Categorization and Augmented Utilization of the Gene Ontology

Eugene Hinderer
Ontologies provide an organization of language, in the form of a network or graph, which is amenable to computational analysis while remaining human-readable. Although they are used in a variety of disciplines, ontologies in the biomedical field, such as Gene Ontology, are of interest for their role in organizing terminology used to describe—among other concepts—the functions, locations, and processes of genes and gene-products. Due to the consistency and level of automation that ontologies provide for...

Investigating the impact of the diseases of despair in Appalachia

Michael Meit, Megan Heffernan & Erin Tanenbaum
Introduction: Appalachia is one of the regions most significantly impacted by the opioid crisis. This study investigated mortality due to diseases of despair within the Appalachian Region, with an additional focus on deaths attributable to opioid overdose. Methods: Diseases of despair include: alcohol, prescription drug and illegal drug overdose, suicide, and alcoholic liver disease/cirrhosis of the liver. Mortality data from the National Center for Health Statistics (NCHS) National Vital Statistics System (NVSS) Multiple Cause of...

West Virginia’s Sugary Drink Tax

Lauri Andress, Ogaga Urhie & Christine Compton
Introduction: Framing is an important aspect of the policy process that helps the public and decision makers sort through and resolve highly charged claims about an issue. Through slight changes in the presentation of issues, a framing effect may alter public support. The way a proposed sugary drink tax is discussed in public discourse and by the media significantly influences policy acceptance. Given the public health significance of obesity and diabetes in West Virginia (WV)...

Sábato

Héctor M. Gutiérrez
Se propone una periodización de la vida y obra de Sábato en tres etapas bien definidas. Estas tres fases, instauradas en su formación intelectual, se bosquejan progresivamente, siguiendo un orden no estrictamente cronológico, sino equilibradamente estructurado por los siguientes temas o preocupaciones centrales de cada período: la ciencia, (1925-1955) la política (1956-1976) y la espiritualidad (1980-2011). La primera etapa, esbozada en el presente artículo, delimita su profundo rompimiento con el mundo de la razón instrumental...

Pos-simulacro e hipermodernidad en Como la sombra que se va, de Antonio Muñoz Molina

Sergio Restrepo
Demostraré que Antonio Muñoz Molina, en su novela Como la sombra que se va (2014) supera el paradigma posmoderno de simulacro. La novela entrecruza geográficamente Lisboa tres relatos: una crónica de la escapada de James Earl Ray después de asesinar al reverendo Martin Luther King y las memorias de la creación tanto de su novela El invierno en Lisboa (1987) como de Como la sombra que se va. Muñoz Molina proyecta la crónica de Ray...

Antología imprescindible

Rómulo Bustos Aguirre
Copyright: © 2016 The Author(s). This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided that the original author(s) and the publication source are credited.

Boundary Layers in Periodic Homogenization

Jinping Zhuge
The boundary layer problems in periodic homogenization arise naturally from the quantitative analysis of convergence rates. Formally they are second-order linear elliptic systems with periodically oscillating coefficient matrix, subject to periodically oscillating Dirichelt or Neumann boundary data. In this dissertation, for either Dirichlet problem or Neumann problem, we establish the homogenization results and obtain the nearly sharp convergence rates, provided the domain is strictly convex. Also, we show that the homogenized boundary data is in...

Islamofobia y conversiones en Los cautivos de Argel

Alba Fernández
Los cautivos de Argel, de Lope de Vega, nos acerca a los problemas religiosos propios de la sociedad española de la temprana modernidad. El deseo de la monarquía por extender la influencia del catolicismo dentro de sus fronteras en un periodo de la historia en el que conviven varias confesiones religiosas se vinculará con la idea de negación de identidad. Sobre este escenario, la historia de amor prohibido entre moros y cristianos actuará como hilo...

Do Bulimic Behaviors Increase Shame?

Heather A. Davis
Binge eating is a harmful, maladaptive behavior associated with comorbid psychopathology. Theory posits that increases in maladaptive, transdiagnostic emotions following binge eating in individuals with BN may predict the experience of comorbid symptoms. The current study served as a laboratory test of the first part of this theory: whether state increases in maladaptive emotions occur following engagement in binge eating behavior in women with BN compared with healthy controls. Women (n = 51) were recruited...

Preclinical Targeting of TREM2 for the Treatment of Alzheimer's Disease-Type Pathology in a Transgenic Mouse Model

Brittani Rae Price
Alzheimer's disease (AD) is defined as a progressive neurodegenerative disorder and is characterized by a devastating mental decline. There are three pathological hallmarks of the disease necessary for its diagnosis, these are extracellular amyloid plaques comprised of the beta-amyloid (Aβ) protein, intracellular neurofibrillary tangles comprised of hyperphosphorylated tau protein, and marked neuronal loss. Active immunization against Aβ1-42 or passive immunization with monoclonal anti-Aβ antibodies has been shown to reduce amyloid deposition and improve cognition in...

Partita for 8 Voices & Wind Ensemble

Kaitlin Bove
Partita for 8 Voices (2012) is a groundbreaking a cappella work that earned its composer, Caroline Shaw, the record of youngest recipient of the Pulitzer Prize for Music in 2013. While the work continues to receive performances from its premiere ensemble, Roomful of Teeth, no transcription of the piece to any other ensemble type existed at the beginning of this DMA project. The author sought to transcribe a piece by a living female composer with...

Characterizing an In Vitro Model of Severe Focal Traumatic Brain Injury in Hippocampal Slice Cultures

Julia Elaine Jagielo-Miller
In the United States, 2.8 million people suffer a traumatic brain injury (TBI) annually. Between 25%-50% of TBI injuries happen under alcohol intoxication. It is not understood how alcohol impacts patient outcomes via secondary injury pathways. Secondary injury pathways offer a window for therapeutic interventions, but there has been little success finding effective medications. Slice cultures offer a way to study secondary injury mechanisms in a controlled manner. The transection injury can model excitotoxicy seen...

Autologous Peripheral Nerve Grafts to the Brain for the Treatment of Parkinson's Disease

Andrew Welleford
Parkinson’s disease (PD) is a disorder of the nervous system that causes problems with movement (motor symptoms) as well as other problems such as mood disorders, cognitive changes, sleep disorders, constipation, pain, and other non-motor symptoms. The severity of PD symptoms worsens over time as the disease progresses, and while there are treatments for the motor and some non-motor symptoms there is no known cure for PD. Thus there is a high demand for therapies...

Exploring the Role of Insulin Receptor Signaling in Hippocampal Learning and Memory, Neuronal Calcium Dysregulation, and Glucose Metabolism

Hilaree Frazier
In the late 90’s, emerging evidence revealed that the brain is insulin-sensitive, highlighted by broad expression of brain-specific insulin receptors and reports of circulating brain insulin. Contemporary literature robustly supports the role of insulin signaling in normal brain function and suggests that insulin-related processes diminish with aging, evidenced by decreased signaling markers, reduced insulin receptor density, and lower levels of insulin transport across the blood-brain barrier. In the context of pathological cognitive decline, clinical trials...

The Economic Impacts of Land Use Policies in Lexington, Kentucky

Christopher R. Bollinger, William H. Hoyt, Michael W. Clark & Xiaozhou Ding
Every five years, Lexington-Fayette Urban County Government’s Planning Commission adopts a comprehensive plan detailing goals and objectives that guide the city’s land use planning. Maintaining the city’s urban service area and preserving its rural and agricultural areas are integral parts of this plan. Within the urban service area, land is zoned to permit various types of urban uses such as residential, commercial, and industrial use. Land outside the urban service area is subject to several...

An Evaluation of How Repealing West Virginia’s Prevailing Wage Law Affected the Cost of Public Construction

Michael W. Clark & Kenneth Tester
This study compared school construction costs before and after legislative changes to prevailing wage laws in West Virginia. The study uses data provided by the School Building Authority of West Virginia (SBA). The data suggests that school construction costs increased in the years prior to the legislative changes and decreased after. Comparing projects bid with and without prevailing wages since 2013 suggests construction costs per square foot decreased by 7.3 percent since the removal of...

The Forestry Reclamation Approach

William E. Bond
The spread of surface coal mining has resulted in loss of forests in the Appalachian region. The Forestry Reclamation Approach (FRA) was developed to provide guidance for restoring forests on reclaimed mined land. This study hypothesizes that the FRA will result in larger magnitude of sediment accumulation rates in reclaimed mine sites compared to those reclaimed using grassland reclamation. Three sediment cores and six trenches were sampled within four reclaimed mined and three previously logged...

CO2-Enhanced Gas Recovery in Shale

Brandon C. Nuttall
The Kentucky Geological Survey tested CO2-enhanced gas recovery in the Devonian shale in Johnson County, in response to a directive from the Kentucky General Assembly in 2007; the study site included a fracture-stimulated shale-gas well. To supplement a standard suite of open-hole logs acquired when the well was drilled, a well-logging program was designed to identify open perforations, construct a flow profile, and acquire pre-injection baseline data to characterize the Devonian Ohio Shale for a...

Integrating Cover Crops and Herbicides for Horseweed [Conyza canadensis (L.) Cronq.] Management Prior to Soybean [Glycine max (L.) Merr.]

Austin Sherman
Horseweed (Conyza canadensis (L.) Cronq.) is prevalent in Kentucky and can be difficult to control. Research has shown multiple weed control methods to be more sustainable than relying on chemical control alone, so the use of multiple methods for horseweed management was examined in this study. The main objective was to determine best practice(s) to reduce horseweed prior to soybean [Glycine max (L.) Merr.]. Treatments included: fall-planted cover crop [CC; cereal rye (Secale cereale L.)...

Redefining Construction As-Built Plans to Meet Current Kentucky Transportation Cabinet Needs

Victoria Lynn Lasley, Steven Waddle, Tim Taylor & Roy E., Jr. Sturgill
As-built plans have traditionally been used by construction industry practitioners to record changes made during construction. As-builts provide valuable information for new design projects as well as rehabilitation and remediation projects. The completeness and accuracy of these plans are essential for transportation industries and their success. While the importance of as-builts is widely recognized, preparing them can be difficult and time-consuming; many entities — especially public agencies — lack the resources necessary to produce accurate...

A Compromised Liver Alters PCB Toxicity and Nutrient Metabolism

Jazmyne D. L. Barney
Environmental contamination is a public health concern. In particular persistent organic pollutants like Polychlorinated Biphenyls (PCBs) have been associated with multiple chronic inflammatory diseases, including non-alcoholic fatty liver disease (NAFLD). NAFLD prevalence has steadily increased and is expected to continue to rise with an estimated 25% of the world’s population and 80-100 million people affected in the United States alone. Importantly, the liver is the primary site for endobiotic and xenobiotic metabolism, hence its proper...

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