424 Works

A Love Rooted Deep in the Appalachian Mountains: One Part of the Legacy of Doug Scutchfield

Charlotte S. Seidman
F. Douglas Scutchfield, MD, died on Monday, May 23, 2022 in Lexington KY. I have known and worked with Doug for over 40 years and share my personal insights into how he created the Journal of Appalachian Health, one of his last great career adventures and a lasting legacy to his deep investment in the health and vitality of Appalachia and its people.

On We Go, with Hope: Remembering Our Founding Editor-in-Chief, Dr. F. Douglas Scutchfield

Rachel E. Dixon & Randolph F. Wykoff
With the passing of our founding Editor-in-Chief, Dr. F. Douglas Scutchfield, the Journal of Appalachian Health team reflects on a life well lived and a monumental public legacy left behind. We thank "Scutch" for enriching the lives of so many, and we commit to growing the Journal in his honor.

THREE ESSAYS ON FOOD SAFETY AND PRIVATE FOOD SAFETY CERTIFICATIONS

Lijiao Hu
In the first essay, we provide a comprehensive literature review of the market of private food safety standards. Since the inception of private food safety standards in the late 1990s, producers, processors, retailers, and governments have been increasingly relying on them to provide assurances to food safety. This article first develops a conceptual framework for the market of private food safety standards through the lens of agri-food supply chain logistics, outlining how the key players...

Interleukin-1 Receptor 1 signaling in mild TBI

Colleen N. Bodnar
Across the world, over 69 million people sustain a traumatic brain injury (TBI) per year making TBI a major health concern worldwide. Of all the TBIs that occur each year, it is suggested that up to 90 percent are mild in nature. Even a mild TBI causes both physical damages to the cells of the brain and activation of a variety of biochemical cascades. Inflammation is an extremely common pathology seen in the brains of...

Essays on Immigration Policy

Andres Felipe Mira
Considerable interest has been placed on the subject of what to do with the sizable undocumented population currently residing in the United States. Having a full understanding of the size of this population and the impact immigration policy has on them is of critical importance to policy makers. Data limitations in nationally-representative surveys have limited the analyzes of the effects of immigration policy in the academic literature. As such, this dissertation consists of three essays...

OPTIMIZING NITROGEN MANAGEMENT IN WINTER WHEAT PRODUCTION SYSTEMS FOR IMPROVED BREAD BAKING QUALITY

Ammar Al Zubade
In Kentucky, there is growing interest among farmers to produce high protein and strong gluten wheat that is suitable for bread baking to meet the demand of local artisanal bakers. Soft red winter wheat (SRW) is the most commonly wheat grown in the state and throughout the Southeastern US. Flours produced from SRW are relatively low in grain nitrogen (N) due to the region’s moderate winters and warm humid conditions during grain filling. As such,...

DISSECTING THE ROLE OF ACTIN-MYOSIN MOTOR AND CALCIUM – BASED ORGANELLE SECRETION IN MOTILITY OF SARCOCYSTIS NEURONA

Parul Suri
Sarcocystis neurona is a protozoan parasite that causes a rare neurological disorder in horses called Equine Protozoal Myeloencephalitis (EPM). Apicomplexa use actin-myosin based motor and organelle secretion to interact with the host cell and invade it. Despite the importance of motility and invasion-needed factors, the mechanisms by which S. neurona employs host cell association strategies to interact remains largely undefined. To address this knowledge gap, we hypothesize that just like other Apicomplexa, S. neurona utilizes...

Crystal Engineering of Asymmetric and Pyrene Fused Annulenes for Use in Organic Electronic Materials

Garrett Fregoso
Since the development of TiPS Pentacene, the use of trialkylsilylethynyl groups has become a commonly utilized moiety for stabilizing, solubilizing, and directing crystal packing of acenes and acene-like compounds, leading to the development of a well-defined series of trends that aid in the prediction of crystal packing for the development of organic semiconducting materials. While these trends have been extensively studied in mainly symmetric linear systems, it is important to determine how, if at all,...

The Site Evaluation of Quercus alba Metabolites

Zachary Byrd
Quercus alba has been the prominent tree species utilized in the spirits industry for decades. Of its many qualities, the ability to impart desirable flavors on spirits combined with its natural abundance makes it the ideal choice for barrels. Creating barrels is a uniform process, but variability still exists in aged spirits even when all other parameters are controlled. In this thesis, I explore how the origin of Quercus alba influences metabolite variability. Quercus alba...

INVESTIGATING THE ROLE OF CHD7 AND SOX11 IN RETINAL CELL DEVELOPMENT AND THE OCULAR COMPLICATIONS OF CHARGE SYNDROME

Laura Krueger
Proper formation of the visual system requires the precise interaction of several embryonic cell lineages, including the neuroectoderm (forms the retina and retinal pigment epithelium), surface ectoderm (forms the lens), mesoderm and cranial neural crest cells (form the ocular blood vessels and anterior ocular structures). When this process is disrupted structural birth defects such as coloboma result, leading to pediatric visual deficits. Ocular developmental defects are often present in larger syndromic disorders. One example is...

Influence of Bedrock Erodibility on Orogen Evolution in Collisional Systems and Implications for Geodynamic Models

Stephanie Sparks
Theoretical and numerical geodynamic models of continental collisional systems often involve, either explicitly or implicitly, a necessary yet complicated dependence between tectonics and erosion; however, the exact nature of these relationships remains elusive and controversial. In such models for the Himalayan-Tibetan (H-T) collisional orogen, surface processes are theorized or in some cases required to play an essential role in modulating critical processes active in the evolution of that system. To investigate, at least to first...

JOCELYN HAGEN’S CHORAL SETTINGS ON TEXTS BY SARA TEASDALE

Elizabeth Wilson
This paper seeks to gain insight into American composer Jocelyn Hagen’s musical style, delving into her compositional process through analyses of three of her choral settings of Sara Teasdale’s poetry: April and the Sun, To See the Sky, and Joy. This work offers a detailed analysis of each piece using Jan Larue’s analytical method, which focuses on the basic musical elements of sound, harmony, melody, rhythm, and growth (known through its abbreviated form as SHMRG)....

Landslide Susceptibility Map of Pike County, Kentucky

Matthew M. Crawford, Hudson J. Koch, Jason M. Dortch & William C. Haneberg
The purpose of this map is to identify landslide-prone areas in Pike County in order to provide the public, as well as local and state government agencies, with information about where landslides are likely to occur. This map represents geomorphic-based susceptibility modeling that focuses on physical slope characteristics and morphology, the quality of which is dependent on data accuracy and resolution of terrain models. The availability of high-resolution (5-ft digital elevation model) lidar derived datasets...

Integration of Utility Engineering, Coordination, and Highway Design

Tim Taylor, Roy Sturgill, Kenny Franklin, Shani A. Montes Victorio & Gabi Dadi
State transportation agencies (STAs) strive to deliver highway projects on time and on budget. Utility relocations are frequently cited as a primary reason for delays. This report describes a new approach for enhancing the alignment of utility coordination and design. Researchers crafted this new approach based on the findings of a literature review, an evaluation of how utility coordination milestones and project development milestones are currently aligned at the Kentucky Transportation Cabinet (KYTC), and the...

THE RELATIVE CONTRIBUTION OF LIVER AND INTESTINE IN REVERSE CHOLESTEROL TRANSPORT

Rupinder Kaur
Despite decades of advances in research, death due to cardiometabolic disease remains the largest contributor to mortality in the US. While present therapies oppose “forward cholesterol transport,” and atherosclerotic plaque progression, they do not remove cholesterol from established atherosclerotic plaques. Reverse cholesterol transport (RCT) is the active process of mobilizing peripheral cholesterol for excretion through the hepatobiliary (transhepatic cholesterol elimination, THCE) or intestinal (transintestinal cholesterol elimination, TICE) pathways. Currently, there are no clinically approved therapeutics...

Updating the Bridge Construction Cost Database

Rachel Catchings, Ying Li, Ryan Griffith & Sudhir Palle
Adopting a comprehensive suite of methods to track, analyze, and maintain data on bridge construction costs can help state transportation agencies identify and implement strategies to mitigate the influence of factors which escalate project costs. This report discusses how the Kentucky Transportation Cabinet (KYTC) should approach updating, maintaining, and analyzing its bridge construction cost data. Based on a review of practices introduced at other agencies and interviews with public and private industry stakeholders, the report...

Image Geo-localization with Cross-Attention

Connor Greenwell
The problem of estimating the location from which un-geotagged photographs were captured has been well studied by the computer vision community in recent years. The central proposal of this thesis is to define a common framework within which existing approaches can be constructed and evaluated, and to introduce a new method under this framework which uses cross-attention between the query image and a database of satellite imagery with known geotags. Our experiments fit within three...

Exploration of Vaccination Attitudes Among Parents and Caregivers in a Rural Appalachian Health Clinic

Radwa Omar, Karen Hande & Natasha McClure
At a rural Appalachian health clinic in Kentucky, 20% of patients under 18 years were not up to date with the CDC-recommended immunization schedule. Reasons parents or caregivers chose to delay or refuse their child’s immunizations were explored using the Caregiver Vaccination Attitude Scale. High levels of trust in the healthcare provider and self-reported vaccine knowledge highlight opportunities for rural healthcare providers to apply evidence-based communication strategies to address vaccine hesitancy and promote the safety...

Exploring the Relationship Between Place Attachment and Attitudes Toward Tourism Development in Powell County

Lindsay Vance
This study explores the relationship between Powell County, Kentucky residents’ place attachment, and the perceived sociocultural, environmental, and financial benefits of the future Warrior’s Path development. A survey consisting primarily of five-point Likert scale questions was shared with several local organizations to distribute to their members. The Pearson’s correlation coefficient and Chi-square test of independence tests were used to discover any correlation between place attachment and perceived sociocultural, environmental, and financial benefits of tourism development....

The role of Shoc2 in embryonic development

Rebecca Norcross
The canonical ERK1/2 signaling cascade regulates cellular functions critical in vertebrate embryonic development such as proliferation, apoptosis, differentiation, and migration. Thus, its signals are controlled by a variety of mechanisms. Scaffold proteins are considered central to the mechanisms regulating the transmission of the ERK1/2 signals. Yet, their functions in development nor the molecular mechanisms by which they exert their control are not well understood. This study focuses on the essential regulator of ERK1/2 signals during...

Authentically Advocating

Gabrielle Dudgeon
Now more than ever, organizations utilize public relations to build, maintain, and even strengthen relationships with internal and external stakeholders. Many public relations strategies and tactics serve to bridge an organization’s interests with those of their publics, while also building, maintaining, and strengthening trust. Social issues management is one of the tools that has the potential to build long-term trust and commitment. Public relations practitioners have recognized this opportunity, and most engage in social issues...

EXPERIENTIAL-BASED FEEDBACK DURING ALCOHOL INTOXICATION AND ITS EFFECT ON DRINKERS’ RISK AWARENESS

Alexandra Kelly
The prevalence of alcohol-impaired driving injuries and fatalities has not decreased for over a decade despite strategies to reduce and prevent driving under the influence of alcohol (DUI). In 2019, 10,142 people died in alcohol-impaired driving crashes in the United States, which totaled to 28% of all traffic fatalities for the year. DUI interventions have been found to have moderate effects on reducing DUI recidivism. Prevention research has identified a lack of risk awareness in...

THE EFFECTS OF SYSTEM OF LEAST PROMPTS ON PRESCHOOL CHILDREN’S PLAY SKILLS

Hailey D. Helton
This research study utilized a multiple probe design to teach pretend play skills while embedding the system of least prompts teaching strategy during pretend play. Four preschool-aged children with and without disabilities participated in the study. When the system of least prompts was embedded within pretend play, play skills increased.

Linking Bad Credentials to Safety Issues

Andrew Martin
This study assesses (1) the effectiveness of the Kentucky Automated Truck Screening (KATS) system, (2) the relationship between credential and vehicle safety violations, (3) the relationship between credential and driver safety violations, and (4) the relationship between credential violations and crashes. The KATS system, which is installed at weigh stations throughout the Commonwealth of Kentucky, is highly effective at detecting KYU, IFTA, and UCR violations with sensitivities of 80.54, 87.56, and 88.28 percent, respectively. However,...

UNDERSTANDING THE EFFECTS OF EMBRYONIC HYPERGLYCEMIA ON RETINAL DEVELOPMENT AND MAINTENANCE

Kayla Titialii-Torres
Hundreds of millions of people are affected by diabetes worldwide. Whether they are diagnosed with prediabetes or Type I or II diabetes, there are a variety of mechanisms in the pathogenesis of diabetes. Diabetes is a disease which consists of recurring states of hyperglycemia that can be difficult to manage due to either lack of insulin production or improper utilization of insulin. While these mechanisms of action differ, complications induced by diabetes occur in both...

Registration Year

  • 2022
    424

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