522 Works

A Constructive Approach to Managing Faculty Conflict

Natasha L. Davis
Research indicates colleges and universities are faced with an excess of challenges and issues, and one of these issues is dealing with conflict. The purpose of this mixed methods action research study was to implement a conflict management strategies workshop on the campus of Morehead State University as an intervention to address the problem of conflict between faculty and administrators. Data collected and analyzed from an exploratory pilot study included interviews of current faculty and...

A THEORETICAL STUDY ON INTEGRATION AND OPTIMIZATION OF GAS TURBINE PROBLEMS WITH SOLAR ENERGY SYSTEM

Ahmad Abubaker
Gas Turbine (GT) power plants suffer from sensitivity to ambient-air temperatures, high fuel consumption, and a high amount of waste heat dumped into the ambient. Various solutions were proposed to solve these drawbacks, which could simultaneously solve at most two problems, usually at the expense of the third. For instance, inlet-air cooling can reduce ambient-air temperatures but will result in increased fuel consumption. However, in this work, a novel cascaded system was integrated into a...

EFFECTIVE FIELD THEORY APPLICATIONS: FROM DARK MATTER TO NEUTRINO NUCLEON SCATTERING

Qing Chen
Weakly-interacting-massive-particles (WIMPs) are a large class of viable dark matter candidates. We compute cross sections for electroweak-doublet WIMPs scattering on atomic nuclei, at leading and subleading order using heavy WIMP effective field theory. Neutrino-nucleon charged current elastic scattering is an important process in the detectors of long baseline accelerator neutrino oscillation experiments. We compute QED radiative corrections to this process employing soft-collinear effective field theory.

Novel Mammalian Models for Understanding and Treating Spinal Cord Injury

Michael Orr
Spinal cord injury (SCI) is devastating and often leaves the injured individual with persistent dysfunction. The injury persists because humans have poor wound repair and there are no pharmacologic treatments to induce wound repair after SCI. The continued efforts to discover therapeutic targets and develop treatments heavily relies on animal models. The purpose of this project is to develop and study novel mammalian models of SCI to provide insights for the development and effective implementation...

Factors Associated with Lifestyle Modification for Type 2 Diabetes Self-Management and Prevention

Leigh Koonmen
Diabetes is the seventh leading cause of death in the United States, affecting roughly 13% of U.S. adults aged 18 years or older. Type 2 diabetes accounts for 90-95% of all diabetes cases and is characterized by the progressive development of insulin resistance leading to sustained elevated blood glucose levels. Management of type 2 diabetes includes risk-reduction strategies and continuous medical care to prevent the development of complications. Lifestyle is a major contributing factor to...

CARNOSIC A CARNOSIC ACID DIFFEREN CID DIFFERENTIALLY MODUL Y MODULATES THE NRF2- TES THE NRF2- ANTIOXIDANT RESPONSE IN M T RESPONSE IN MALE AND FEM ALE AND FEMALE MICE ALE MICE FOLLOWING EXPERIMEN OWING EXPERIMENTAL TRAUMATIC BRAIN INJUR TIC BRAIN INJURY

Jacob Dunkerson
Traumatic brain injury (TBI) is a leading cause of death and disability in the United States. Each year, an estimated 2.8 million Americans are diagnosed with a TBI due to falling, motor vehicle collisions, gun violence, and sports related concussions. Although inflicted by a single event, the post-traumatic effects of TBI often develop into a life-long disease. Survivors often experience cognitive decline, memory loss, emotional instability, changes in personality, and physical disabilities. A single TBI,...

KENTUCKY FOREST SECTOR

Domena Attafuah Agyeman
The Kentucky forest sector plays a key role in ensuring economic stability and enhanced livelihood for both rural and urban communities in the state. Therefore, it is important to implement policies and measures to sustain and improve the sector. One way to attract attention and engage policy makers in discussions on the need for measures to sustain the sector is to undertake comprehensive assessments that would enhance understanding of economic contributions and impacts associated with...

BUILDING COMMUNICATION, COLLABORATION, AND SELF-EFFICACY AMONG ELEMENTARY SCHOOL COUNSELORS THROUGH COMMUNITIES OF PRACTICE

Garrett Rimey
There are few life-changing experiences like transitioning from elementary school to middles school. A new setting, new peers, new teachers, and new structures have been shown to elicit a myriad of emotions from students as they transition into middle school. A student’s academic record, accommodations, and other pertinent academic information follow a student into middle school; however, their social and emotional portfolio does not. Research has shown that students who are negatively impacted the most...

PHARMACOKINETICS AND REWARD-RELATED BEHAVIORS OF ETHANOL IN MALE AND FEMALE JAPANESE QUAIL (COTURNIX JAPONICA)

Shannon Eaton
Ethanol is one of the most widely used and abused drugs. Problem use is associated with many different health problems and the economic burden is in the billions of dollars. Additionally, many people have difficulty controlling their ethanol consumption and about 5% of adults end up with an alcohol use disorder (AUD). Many people with an AUD often find themselves in a cycle of binge, remission, and relapse. Following ethanol consumption ethanol enters the bloodstream...

THE USE OF MECHANOTHERAPY TO PROMOTE THE RECOVERY FROM DISUSE ATROPHY IN AGING RAT SKELETAL MUSCLE

Zachary Hettinger
The combination of age and disuse-related skeletal muscle atrophy predisposes older adults to reduced mobility, loss of independence, and poor quality of life. Poor health outcomes resulting from periods of disuse in older adults are exacerbated by an inability to fully recover, ultimately accelerating geriatric populations towards further functional decline. Aged-related changes to skeletal muscle viscoelastic properties, specifically of muscle extracellular matrix (ECM) stiffness, may not only impact how muscle responds during recovery, but also...

Investigation of Multidrug Efflux Transporter AcrB in Escherichia coli

Prasangi Rajapaksha
The Resistant Nodulation Division (RND) super family member, tripartite AcrA-AcrB-TolC efflux pump, is a major contributor in conferring multidrug-resistance in Escherichia coli. The structure of the pump complex, and drug translocation by functional rotation mechanism have been widely studied. Despite of all these data, the dynamics of the assembly process of the pump and AcrB during functional rotation in the process of drug efflux remains poorly understood. My thesis focuses on understanding the pump assembly...

Multiscale Finite Element Modeling of Active Contraction in Striated Muscle

Charles Mann
Greater than one in three American adults have at least one type of cardiovascular disease, a major cause of morbidity. Computational cardiac mechanics has become an important part of the research effort to understand the heart’s response to mechanical stimuli and as an extension, disease progression and potential therapies. To this end, the present work aims to extend these efforts by implementing a cell level contractile model in which active stress generation in muscle tissue...

PREDICTING TOMORROW

Melissa Cantor
The leading causes of morbidity and mortality in preweaned dairy calves are diarrhea and bovine respiratory disease complex (BRD). The delayed detection of these diseases in calves can also delay intervention and disease recovery. The overarching objective of this dissertation was to follow a cohort of calves daily for the first 90 days of life for naturally occurring clinical BRD bouts and diarrheal bouts. The objective answered if feeding behaviors and activity levels were different...

MEETING THEIR EXPECTATIONS: STUDENT EXPECTATIONS AND PERCEPTIONS OF INSTRUCTOR CLARITY, CREDIBILITY, RAPPORT, AND CLIMATE IN ONLINE COURSES

Nicole Kowalski
Continued advancements in technology have steadily increased accessibility to online learning and have provided more tools with which instructors can communicate with their students. As our technology evolves, so too does the students’ expectations for how course content will be communicated. It is important to understand students’ expectations for their online learning experiences so that those expectations can be met. The field of instructional communication has demonstrated the importance of behaviors that establish an instructor’s...

Three Essays on Grocery Sales Taxes

Lingxiao Wang
Grocery sales taxes represent a stable tax revenue stream for state and municipal government, but there is rare empirical evidence suggesting grocery taxes may adversely affect health. In addition, the how governments set grocery sales taxes is still unclear. Therefore, based on a novel national dataset of annual county and state-level grocery taxes from 2009 through 2016, the following three essays in the dissertation investigate the health impacts of grocery sales taxes and the causes...

DEVELOPMENT OF TOOLS FOR ATOM-LEVEL INTERPRETATION OF STABLE ISOTOPE-RESOLVED METABOLOMICS DATASETS

Huan Jin
Metabolomics is the global study of small molecules in living systems under a given state, merging as a new ‘omics’ study in systems biology. It has shown great promise in elucidating biological mechanism in various areas. Many diseases, especially cancers, are closely linked to reprogrammed metabolism. As the end point of biological processes, metabolic profiles are more representative of the biological phenotype compared to genomic or proteomic profiles. Therefore, characterizing metabolic phenotype of various diseases...

LOCALIZATION OF STATIONARY SOURCE OF FLOOR VIBRATION USING THE STEERED RESPONSE POWER METHOD

Mohammad Royvaran
If the generated vibration in a building exceeds the acceptable limit design for a floor system, it is necessary to identify the source of vibration, a process known as localization. The objective of this study is the localization of stationary vibration sources, and the approach used is the steered response power (SRP) method. This method has already been shown to work well for wireless and acoustical applications to locate transmitter and sound sources, respectively. To...

DELINEATING THE ROLE OF FATTY ACID METABOLISM TO IMPROVE THERAPEUTIC STRATEGIES FOR COLORECTAL CANCER

James Drury
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths in the world, comprising over 1 million new cases each year and over 500,000 deaths. CRC, when detected at an early stage of disease development, can be effectively treated, with a 5-year survival rate of over 90%. Such standard treatments include surgical resection of the primary tumor in combination with adjuvant chemotherapy. However, even with advancements in surgical procedures and chemotherapeutic targets, when CRC progresses...

Mechanisms of Programmed Nutrition in Finishing Cattle in Vivo and Ruminal Parameters of Amaize Supplementation in Vitro

Amanda Pesqueira Schiff
Programmed Nutrition Beef Program (Alltech Inc.) is a dietary supplement that contains Aspergillus oryzae fermentation extract with α-amylase activity that could reduce the use of feed additives such as monensin and tylosin in conventional feedlot diets. This study examines the changes in rumen fermentation resulting from feeding monensin/tylosin and Programmed Nutrition Beef Finisher. The goal was to determine if these shifts in rumen fermentation contribute to the Programmed Nutrition response observed in vivo. This study...

Uncovering the Role of ApoE4 on Alzheimer’s Disease-Related Neuroinflammation

Courtney Kloske
Alzheimer’s disease (AD) is the most common neurodegenerative disease and is characterized by two hallmark pathologies: amyloid-beta plaques (Ab plaques) and hyperphosphorylated, aggregated tau tangles. These pathologies are typically accompanied by the presence of neuroinflammation which is primarily mediated by microglia. Interestingly, several genetic risk factors that increase the risk of AD also have direct impacts on neuroinflammation. Of interest, Apolipoprotein E (ApoE) is the largest genetic risk factor for AD. ApoE has three isoforms-...

Optical Metasurfaces

Fatih Balli
Traditional optical elements, such as refractive lenses, mirrors, phase plates and polarizers have been used for various purposes such as imaging systems, lithographic printing, astronomical observations and display technology. Despite their long-term achievements, they can be bulky and not suitable for miniaturization. On the other hand, recent nanotechnology advances allowed us to manufacture micro and nanoscale devices with ultra-compact sizes. Metasurfaces, 2D engineered artificial interfaces, have emerged as candidates to replace traditional refractive lenses with...

THREE ESSAYS ON PRICE ANALYSIS AND INTERNATIONAL TRADE

Wei Zhang
The first chapter of this dissertation examines price discovery and volatility spillovers in the coffee spot-futures commodity market over the post-ICA period by employing the PT-IS and bivariate EGARCH models. This research covers two actively traded coffee types, Arabica and Robusta, and utilizes daily time-series price data over 1990:01-2020:04 for Arabica and over 2008:01-2020:04 for Robusta. The empirical results indicate that coffee spot markets play a dominant role in the coffee price discovery for both...

LEVERAGING TRANSCRIPTOMIC APPROACHES TO IDENTIFY DIFFERENCES IN GENETIC PROGRAMMING DRIVING TWO DISTINCT WOUND HEALING MECHANISMS, REGENERATION AND FIBROSIS, IN ACOMYS AND MUS

Shishir Biswas
Why can some animals and others cannot? This fundamental question has fueled scientists studying regeneration for hundreds of years since early observations in crayfish, salamanders and many other organisms. While most contemporary work in regeneration is done in a handful of species including salamanders, zebrafish and flatforms, these organisms lack a closely-related, non-regenerating sister species from which unique genetic differences can be identified. Additionally, while much has been learned from these organisms, they do not...

Communication Strategies to Intervene in Intimate Partner Violence Among Young Adult Couples

Kaylee Lukacena
Intimate partner violence (IPV) is a social and behavioral health issue of importance among the young adult population (Cupp et al., 2015). IPV includes acts of physical violence, sexual violence, psychological aggression, and stalking enacted by an intimate partner (Smith, Zhang, Basile, Merrick, Wang, Kresnow, & Chen, 2018). In the United States., approximately one in three women and one in ten men experience IPV during their lifetime (Smith et al., 2018). Furthermore, over more than...

Effects of Season and Nutrition on Insulinemic Responses in Insulin Dysregulated Horses

Erica Macon
Insulin dysregulation (ID) is the main risk factor for the development of hyperinsulinemia-associated laminitis (HAL). ID in the equid has been extensively researched; however, recommendations for diagnosing and managing ID horses have originated from work completed in other models, such as the ID pony and healthy horse. Therefore, our overall objective was to improve current diagnostic tools and nutritional management strategies by investigating the effect of season, the fed and fasted state on the oral...

Registration Year

  • 2022
    227
  • 2021
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Resource Types

  • Dissertation
    522

Affiliations

  • University of Kentucky
    521