522 Works

ABC TRANSPORTERS IN GLIOBLASTOMA

Julia Schulz
Glioblastoma is one of the deadliest cancers, with a median survival of only one year. Even after aggressive treatment consisting of surgical resection, radiation, and chemotherapy, most glioblastoma patients suffer from tumor recurrence within 6-9 months. One reason for treatment failure of anticancer drugs is the blood-brain barrier that protects the brain by impeding xenobiotic uptake from the blood. To this end, efflux transporters at the human blood-brain barrier, such as P-glycoprotein (ABCB1) and Breast...

THE EFFECTS OF A STRENGTHS BASED FACULTY COACHING INTERVENTION ON FIRST-YEAR UNDERGRADUATE STUDENT ACADEMIC CONFIDENCE

Conrad Davies
Deficiency remediation models of education imply that students may enter the university with deficiencies, problems, or needs that imply the student needs to be “fixed” before they can proceed in their academic studies. In contrast, strengths-based education models infer that students come to the university with inherent talents, natural propensities, and behaviors that can be leveraged to overcome their challenges. These differing perspectives can influence the effectiveness of university policies designed to improve student retention....

Psychological Distress and Relationship Satisfaction Among Survivors of Sexual Violence

Alyssa Campbell
The World Health Organization (WHO; 2002) has indicated that sexual violence is a serious public health concern, and both the WHO and the United Nations (UN) have declared that violence against women, in particular, is a profound violation of human rights (UN General Assembly, 1993; WHO, 2017). Although the systemic and negative impact of trauma on family and intimate relationships have been well documented, the empirical literature regarding the effects of adult sexual trauma on...

Utilizing a Theory of Change Process to Establish Framework for a Student Success Course

Sy Bridenbaugh
The student success course has become a staple of the college experience. As the academic and social environment continues to shift with each new incoming cohort, having a designed and evaluated framework to utilize during student success course development can be a useful tool. Research surrounding student success in college is abundant. Having a framework that draws on this research for setting learning objectives and determining high impact practices for a student success course could...

AN EXAMINATION OF HIGH SCHOOL PHYSICAL EDUCATION TEACHERS SUPPORT OF STUDENTS’ PHYSICAL ACTIVITY SELF-EFFICACY

Kenneth Murfay
Providing students with experiences to increase their confidence (self-efficacy) to be physically active is important because of the many health benefits associated with physical activity (U.S. Department of Health and Human Services [USDHHS], 2020). Several studies have shown that physical activity (PA) tends to decline as students age (Cooper et al., 2015; Metcalf et al., 2015; Troiano et al., 2008) and the largest declines usually occur in adolescence (Sallis, 2000). It is recommended that physical...

INCORPORATION OF SUMMER ANNUAL MIXTURES INTO GRAZING SYSTEMS IN KENTUCKY

Kelly Mercier
Utilizing summer annual grass-legume forage mixtures has the potential to improve forage yield and nutritive characteristics, and/or animal performance during times when cool-season pasture growth is limited by high temperatures. Legumes can utilize atmospheric nitrogen, which can increase crude protein and forage digestibility in mixtures. As nitrogen application generally improves both the yield and nutritive characteristics of summer annual forages, but can have a negative effect on legume competitiveness, nitrogen fertilizer recommendations for legume-containing summer...

Determining Material Structures and Surface Chemistry by Genetic Algorithms and Quantum Chemical Simulations

Josiah Roberts
With the advent of modern computing, the use of simulation in chemistry has become just as important as experiment. Simulations were originally only applicable to small molecules, but modern techniques, such as density functional theory (DFT) allow extension to materials science. While there are many valuable techniques for synthesis and characterization in chemistry laboratories, there are far more materials possible than can be synthesized, each with an entire host of surfaces. This wealth of chemical...

A Biochemical Characterization of the Fusion Proteins from Enveloped RNA Viruses

Chelsea T. Barrett
Enveloped viruses must bind target cells and then fuse the viral membrane with a cell membrane to enter a host cell. These viruses use one or more surface glycoproteins to carry out these critical functions. The surface glycoprotein that carries out the fusion function, termed a fusion protein, is divided into three classes based on structural similarities. Some of the most studied human viral pathogens, such as human immunodeficiency virus (HIV), Ebola virus, influenza, measles,...

SONGS FOR HIGH VOICE

Makeda Hampton
African Romances, Op. 17, composed in 1897 by African-British composer Samuel Coleridge-Taylor (1875-1912), is a collection of seven songs for high voice that is uniquely both African and American. The lyrics of this song cycle were first published in the book Majors and Minors, a collection of poems published in 1895 by Paul Laurence Dunbar (1872-1906). An analysis of resources supports that academic discourse in Black vocal music has been underrepresented due to the absence...

EVALUATING THE INCIDENCE OF MELANOMA AND LUNG CANCER OF CURRENT AND FORMER ACTIVE-DUTY U.S. MILITARY WHO WERE DEPLOYED IN SUPPORT OF OPERATION ENDURING FREEDOM AND OPERATION IRAQI FREEDOM

Brian Kovacic
The incidence of melanoma and lung cancer has been gradually increasing in the United States over the past three decades with the reputed causes due to etiological and environmental exposures, and tobacco usage. There has been concern that melanoma and lung cancer incidence among military personnel may be associated with deployment to environments with intense sun exposure and increased smoking rates due to post-traumatic stress disorder. The aim of this study was to examine associations...

Optimization of Gelatin-Based Cellular Coating of MSC for Myocardial Infarction Therapy

Kara Davis
Cardiovascular disease remains the number one threat to American lives. During an acute myocardial infarction (AMI), blood flow is blocked and results in the formation of scar tissue. As the body’s immune system responds, inflammatory signaling causes an increase in both scar tissue size and the patient’s risk for further chronic heart failure. In order to reduce the risk of continued heart disease inflammatory signaling must be reduced. Stem cell therapies have the ability to...

USE OF MICROSCALE HYDROPHOBIC SURFACE FEATURES FOR INTEGRATION OF 3D CELL CULTURE INTO MULTI-FUNCTIONAL MICROFLUIDIC DEVICES

Soroosh Torabi
3D cell culture and microfluidics both represent powerful tools for replicating critical components of the cell microenvironment; however, challenges involved in integration of the two and compatibility with standard tissue culture protocols still represent a steep barrier to widespread adoption. Here we demonstrate the use of engineered surface roughness in the form of microfluidic channels to integrate 3D cell-laden hydrogels and microfluidic fluid delivery. When a liquid hydrogel precursor solution is pipetted onto a surface...

QUADRICEPS RECRUITMENT AND TWITCH PROPERTIES IN LEAN AND OBESE WOMEN BEFORE AND AFTER FATIGUING EXERCISE

Rebekah Carpenter
Skeletal muscle strength, specifically that of the anti-gravitational muscles such as the quadriceps, is essential for performing dynamic tasks including walking, navigating stairs, and transitioning between sitting and standing. Obesity has been shown to negatively impact musculoskeletal function and decrease quadriceps strength relative to body weight. Additionally, obesity has been linked with higher rates of fatigue and lower strength outcomes following a test of muscular endurance of the quadriceps. Since obesity lowers relative strength, it...

Three Essays on Export Earnings Volatility

Yoonseon Han
My dissertation consists of three essays on export earnings volatility. In the first essay, I look at the determinants of export earnings volatility. The four main determinants suggested by the theoretical literature are export concentration, durability, vertical linkages, and financial vulnerability. A panel of bilateral trade data at the industry level, containing 178 exporting countries, 194 importing countries, and 590 SITC Rev. 1 four-digit industries from 1962 to 2011, is used and these aspects are...

Fostering A Sense of Community Among Teachers Via A Community of Practice

Apryl Clark Moore
Communities of Practice (CoPs) are learning communities that can improve the skills and knowledge of teachers and improve a sense of community. CoPs are designed to cultivate relationships among teachers and develop professional practices that increase a sense of community and knowledge attainment. This study examined the use an online CoP to increase teachers’ sense of community during the COVID-19 global pandemic. Teachers joined a private online community and shared resources about classroom management strategies....

Three Essays in Regional Taxation

Kenneth Tester
This dissertation looks at the role that geographically limited taxation and the behavioral response of economic agents to different forms of regional taxation. While geographic taxation is typically thought to be confined to state and local taxes, federal tax policy can also create designated areas that receive preferential tax treatment. In this dissertation, both types of regional taxation are examined and are unified under common themes such as tax mobility and the definition of the...

Weight Distributions, Automorphisms, and Isometries of Cyclic Orbit Codes

Hunter Lehmann
Cyclic orbit codes are subspace codes generated by the action of the Singer subgroup Fqn* on an Fq-subspace U of Fqn. The weight distribution of a code is the vector whose ith entry is the number of codewords with distance i to a fixed reference space in the code. My dissertation investigates the structure of the weight distribution for cyclic orbit codes. We show that for full-length orbit codes with maximal possible distance the weight...

MASS SPECTROMETRY METHOD DEVELOPMENT FOR THE DISCOVERY AND CHARACTERIZATION OF SECONDARY METABOLITES

Zachary Kelley
Secondary metabolites are organic compounds produced by an organism for reasons other than growth and development. In plants, secondary metabolites generally act as defense agents produced to deter predators and inhibit other competitive species. For humans, these compounds can often have a beneficial effect and are pursued and utilized as natural pharmaceuticals. The development of sensitive, high-throughput analytical screening methods for plant derived metabolites is crucial for natural pharmaceutical product discovery and plant metabolomic profiling....

FABRICATION OF NANOPOROUS MATERIALS FOR APPLICATIONS UNDER EXTREME ENVIRONMENTS

Maria Kosmidou
The study of nanoporous materials has become a key aspect of nanotechnology due to their high surface-area-to-volume ratio, arising from the small size ligaments and pores that form the structure. Sensing, catalysis, micro-electromechanical systems (MEMS), medical applications, and materials for radiation environments are some of the applications for which nanoporous materials are considered great candidates. This work, performed at the Ion Beam Laboratory (IBL) at Sandia National Laboratories (SNL), examines the effect of heavy and...

Development of a Field Expedient Screening Tool for the Coach to Identify Musculoskeletal Risk Factors in Baseball Players

Kyle Matsel
Identification of musculoskeletal (MSK) injury risk factors in baseball players can be challenging particularly for youth and high school coaches. Many baseball coaches lack a sports medicine and/or strength and conditioning staff to assist with injury prevention initiatives. Given the extensive responsibilities in managing the team and preparing the players for athletic competition, little time remains to focus on injury prevention and arm care programs. Furthermore, assessment, diagnosis, and management of MSK impairments is outside...

AN ASSESSMENT OF THE CARRIER STATE AND A NOVEL MARKER OF LEPTOSPIRA AND ABORTION IN CENTRAL KENTUCKY HORSES

Gloria Gellin
Leptospirosis is a reemerging zoonotic infection of worldwide importance and affects all mammals. The bacterium is transmitted to animals and humans by urine, fetal membranes and body fluids. Leptospira shedding in the urine contaminates both soil and water, exposing both humans and animals to the bacterium. Leptospirosis in horses can cause abortion and is one of the etiologies of equine recurrent uveitis which can lead to blindness. Equine leptospiral abortion in Central Kentucky is primarily...

Weakly Supervised Learning for Multi-Image Synthesis

Muhammad Usman Rafique
Machine learning-based approaches have been achieving state-of-the-art results on many computer vision tasks. While deep learning and convolutional networks have been incredibly popular, these approaches come at the expense of huge amounts of labeled data required for training. Manually annotating large amounts of data, often millions of images in a single dataset, is costly and time consuming. To deal with the problem of data annotation, the research community has been exploring approaches that require less...

DIMENSION REDUCTION TECHNIQUES IN REGRESSION

Pei Wang
Because of the advances of modern technology, the size of the collected data nowadays is larger and the structure is more complex. To deal with such kinds of data, sufficient dimension reduction (SDR) and reduced rank (RR) regression are two powerful tools. This dissertation focuses on these two tools and it is composed of three projects. In the first project, we introduce a new SDR method through a novel approach of feature filter to recover...

DESIGN, SYNTHESIS, AND ANTICANCER PROPERTIES OF Ru(II) COMPLEXES WITH ORGANOMETALLIC, “EXPANDED” BIPYRIDINE, AND O,O’-CHELATING LIGANDS

Raphael Ryan
Cancer is a worldwide public health crisis that requires new and improved drugs to be developed to extend survival rates and improve quality of life for the patient. Platinum-based drugs are used in approximately 50% of cancer treatment regimens. These drugs are highly effective in many kinds of cancer; however, cancers can develop platinum resistance and these drugs have troubling side effects that reduced their use and efficacy. To overcome these disadvantages, many other metals...

FIRST-GENERATION DOCTORAL STUDENTS’ EXPERIENCES NAVIGATING GRADUATE SCHOOL

Leah Vance-Berg
First-generation students who pursue graduate programs face a unique set of challenges and rely on their strengths to help them navigate their graduate programs. This study will look at how first-generation students have navigated their graduate course work. Semi-structured interviews were conducted with 19 doctoral students at Magnolia University where participants discussed the challenges they have faced during graduate school and how they have navigated these challenges. This exploratory study uses social and cultural capital...

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