522 Works

SCIENCE-BASED REGULATION OF PHARMACOLOGICAL SUBSTANCES IN COMPETITION HORSES

Jacob Machin
Current testing methodologies within equine forensic toxicology focus on arbitrary thresholds and zero-tolerance policy. Modern analytical chemistry’s limits of detection are low enough that oftentimes femtogram-per-milliliter amounts of a substance can readily be identified in both blood and urine of a horse. For most pharmacologically relevant compounds, these concentrations have no relevance to pharmacological effect. It is therefore crucial that testing methodologies to determine appropriate thresholds and cut-offs be developed that are driven by biological...

Development and Cross-Validation of Personality Assessment Inventory Decision Rules for the Identification of Psychogenic Nonepileptic Seizures

Chelsea Bosch
The published literature on the Personality Assessment Inventory (PAI) for psychogenic nonepileptic seizure (PNES) diagnosis includes a variety of interpretation methods to distinguish PNES from epileptic seizures (ES) and offers mixed findings. The purpose of this study was to use a cross-validation approach to create and derive new decision rules for the PAI to best differentiate PNES from ES. Data from 773 patients (PNES n = 328, ES n = 445) who underwent long-term video...

Weakly Supervised Learning for Multi-Image Synthesis

Muhammad Usman Rafique
Machine learning-based approaches have been achieving state-of-the-art results on many computer vision tasks. While deep learning and convolutional networks have been incredibly popular, these approaches come at the expense of huge amounts of labeled data required for training. Manually annotating large amounts of data, often millions of images in a single dataset, is costly and time consuming. To deal with the problem of data annotation, the research community has been exploring approaches that require less...

AN ASSESSMENT OF THE CARRIER STATE AND A NOVEL MARKER OF LEPTOSPIRA AND ABORTION IN CENTRAL KENTUCKY HORSES

Gloria Gellin
Leptospirosis is a reemerging zoonotic infection of worldwide importance and affects all mammals. The bacterium is transmitted to animals and humans by urine, fetal membranes and body fluids. Leptospira shedding in the urine contaminates both soil and water, exposing both humans and animals to the bacterium. Leptospirosis in horses can cause abortion and is one of the etiologies of equine recurrent uveitis which can lead to blindness. Equine leptospiral abortion in Central Kentucky is primarily...

Myelin, cPLA2, and Azithromycin

Timothy Kopper
Spinal cord injury (SCI) produces a chronic inflammatory state primarily mediated by macrophages consisting of resident microglia and infiltrating monocytes. These chronically activated SCI macrophages adopt a pro-inflammatory, pathological state that continues to cause additional damage after the initial injury and inhibits recovery. While the roles of macrophages in SCI pathophysiology are well documented, the factors contributing to this maladaptive response are poorly understood. Here, we identify the detrimental effects of myelin debris on macrophage...

Revisiting Absolute Pose Regression

Hunter Blanton
Images provide direct evidence for the position and orientation of the camera in space, known as camera pose. Traditionally, the problem of estimating the camera pose requires reference data for determining image correspondence and leveraging geometric relationships between features in the image. Recent advances in deep learning have led to a new class of methods that regress the pose directly from a single image. This thesis proposes methods for absolute camera pose regression. Absolute pose...

THE EFFECTS OF FORM OF SELENIUM ON THE BOVINE CORPUS LUTEUM, UTERINE ENDOMETRIUM, AND DEVELOPMENT OF THE CONCEPTUS

Benjamin Ryne Crites
Widespread regions of the southeast United States have soils deficient in selenium (Se), necessitating Se supplementation to cattle grazing in these areas. Adequate dietary Se is required for optimal immune function, growth, and fertility. In forages, Se is predominantly found in the organic form (OSe), which is known to increase bioavailability. However, the inorganic form (ISe) is typically found in commercial mineral mixes. We previously reported that supplementation with an isomolar 1:1 mix (MIX) of...

Mobile Technology Use During the COVID-19 Pandemic

Yi Lin
The COVID-19 pandemic led to quarantines and mandatory spatial distancing; people of all ages were encouraged to use technologies instead of actual human contact for COVID-19 prevention and daily activities. The special circumstances of living plus innovation and promotion of mobile applications (apps) during the pandemic influenced mobile technology use behavior. In this study we explored age differences in mobile technology use, the factors that influenced use behavior during the COVID-19 pandemic, and proposed a...

UNDERSTANDING ABSORPTION, SUPERSATURATION, AND DRUG ACTIVITY IN SOLUTION

Freddy Arce
With the looming dominance of poorly water-soluble chemical entities within the pharmaceutical pipeline, the pharmaceutical industry has leaned on the use of supersaturating drug delivery systems (SDDSs) to achieve efficacious concentrations within the gastrointestinal fluids. SDDSs aim to achieve concentrations in solutions greater than the solubility of the lowest energy crystalline form. However, the generation of supersaturated solutions of active pharmaceutical ingredients (APIs) creates a strong crystallization potential, which is undesirable. In product development, supersaturating...

SUCCINYLATED POLYETHYLENIMINE GENE DELIVERY AGENTS FOR ENHANCED TRANSFECTION EFFICACY

MdNasir Uddin
Gene therapy aims to treat patients by altering or controlling gene expression. Today, most clinical approaches are viral-based due to their inherent gene delivery activity. However, there is still a significant interest in nonviral alternatives for gene delivery, particularly synthetic lipids and polymers, that do not suffer the immunogenicity, high cost, or mutagenesis concerns of viral vectors. Polymeric vectors are of particular interest due to the ability to further tune the polymer properties through the...

PARENTAL BARRIERS TOWARD SEEKING MENTAL HEALTHCARE FOR SAUDI CHILDREN AT RISK OF ADHD

Amani Kappi
Attention deficit hyperactivity disorder (ADHD) is a mental health disorder commonly diagnosed in childhood. Underdiagnosis and undertreatment of ADHD can lead to the development of other mental illnesses and disruptions in social functioning in adulthood. Therefore, parents can play a crucial role in proactively seeking mental healthcare for children who are at risk for or who have a clear diagnosis of ADHD. Studies in the United Kingdom and the United States highlight many barriers that...

Early Maturing Out of Problematic Alcohol Use

Sarah Peterson
Most research suggests that alcohol use peaks in the college years then declines into the mid-thirties (Jochman & Fromme, 2010). However, there is evidence that some individuals mature out earlier: downward trends for some individuals begin in college, with as many as one third of students decreasing their drinking (Baer et al., 2001). It is crucial to identify factors that differentiate those who decrease their drinking early from those who persist in high levels of...

TURNING THE TIDES

Sarah Geegan
Extensive research, predating and during the COVID-19 pandemic, demonstrates the rising prevalence of anxiety and depression among Gen Z college students in the United States—findings which are accompanied by rising rates of suicide, the second leading cause of death among people aged 15-24. Although college campuses often offer mental health resources, the number of college students utilizing them is significantly less than the number of students reporting mental health challenges. A dearth of empirical evidence,...

Regulation of Skeletal Muscle Plasticity by the Gut Microbiome

Taylor Valentino
Recent evidence suggests that the gut microbiome could play a role in skeletal muscle plasticity, providing novel treatments for muscle wasting diseases and/or performance enhancements. I first sought to determine if the gut microbiome is necessary for skeletal muscle adaptation to exercise. Forty-two, four-month old, female C57Bl/6J underwent nine weeks of weighted wheel running or remained in cage with a locked wheel, without or without the administration of antibiotics (treated). In response to wheel running,...

LA REPRESENTACIÓN DE LA MASCULINIDAD EN EL PERSONAJE DEL POLICÍA

Daniel Fonfría-Perera
This research focuses on the type of hegemonic masculinity—a term that has traditionally belonged to a purely sociology domain—exhorted in the works of fiction published and released in Spain in the last two decades, searching for patterns that indicate that a normative type is encouraged. After tracing the different types of hegemonic masculinities that have characterized policemen since the late 30’s, the findings show how the modern notion of masculinity depicted in the works analyzed,...

The Hybrid Teacher:

Mary Joy Nelson
The world of professional vocal training is becoming more and more eclectic and demanding in the United States. Academic music programs, and subsequently, vocal and vocal pedagogy programs are still predominantly classical in 2022, due to the American university system’s historical roots. In the 21st century, the commercial music industry is at an all-time high. However, in contemporary academia, vocal and vocal pedagogy degree programs remain primarily classical. In recent years, voice professionals have been...

SOCIAL CONSTRUCTION OF HATE CRIMES IN THE US

Chenghui Zhang
Hate crime is a social construct that is conceptualized and defined through judgments about the meaning of bias and prejudice, as well as the causal link between motivation and criminal act. While the enforcement of federal statutes has extended the protected grounds of hate crime, significant underreporting issues impede the understanding of the actual scale, scope, and severity of hate crimes. The purpose of this dissertation is to investigate what and how incident factors and...

HERSTORY

Rena Curvey
The purpose of this study was to explore women’s professional career experiences in sport psychology. Using qualitative methodology, seventeen female sport psychology practitioners participated in intensive semi-structured interviews from May 2021 to July 2021. This study resulted in two distinct manuscripts. First, guided by constructivist grounded theory methodology, embedded in a feminist standpoint framework, this study developed a grounded theory to help explain what sources attract and retain women in sport psychology. The developed theory...

Batch Normalization Preconditioning for Neural Network Training

Susanna Lange
Batch normalization (BN) is a popular and ubiquitous method in deep learning that has been shown to decrease training time and improve generalization performance of neural networks. Despite its success, BN is not theoretically well understood. It is not suitable for use with very small mini-batch sizes or online learning. In this work, we propose a new method called Batch Normalization Preconditioning (BNP). Instead of applying normalization explicitly through a batch normalization layer as is...

Motivating the Protection of Others

Erin Hester
The term “wicked problems” is used to describe a constellation of social issues that are deeply entangled (Rittel & Webber, 1973). Although these social messes affect everyone in society, some people suffer more than others (Ackoff, 1974). Nevertheless, tackling wicked problems begins with recognizing our shared responsibility to ease the misfortune of others (Rittel & Webber, 1973). As such, they provide an ideal context to investigate the persuasive effectiveness of messages that encourage the protection...

Extraction of Deep Inelastic Cross Sections Using a 10.4 GeV Electron Beam and a Polarized Helium-3 Target

Murchhana Roy
Experiment E12-06-121 at Jefferson Lab aims to do a precision measurement of the neutron spin structure function g2 using inclusive inelastic scattering of electrons over a large kinematic range of x and Q2. The third moment of the linear combination of the spin structure functions g1 and g2, d2, is one of the cleanest higher twist observables and contains information on quark-gluon correlations. It is connected to the “color polarizability or “color Lorentz force” of...

THE ROLE OF NITRIC OXIDE IN INTER- AND INTRA- CELLULAR SIGNALING IN PLANT DEFENSE

Fan Xia
Plants have evolved a sophisticated immune system to defend themselves against pathogens. This immune response can be triggered in response to pathogen-associated molecular patterns (PAMP) or specialized effectors that are recognized by the plant resistance (R) proteins. The latter, commonly referred to as effector-triggered immunity (ETI), is well known to induce broad-spectrum resistance throughout the plants. This phenomenon known as systemic acquired resistance (SAR) is regulated by several chemical signals including salicylic acid (SA), and...

THE BEST OF BOTH WORLDS

Kristy Zak
The purpose of this dissertation was to understand non-tenured and tenured teachers’, administrators’, and literacy support staff’s perceptions of the most imperative practices new teachers should know to teach reading in local elementary schools located in one regional state university’s service region. As well, this dissertation sought to determine the degree to which there was alignment between what is being taught in reading methods classes at one regional, state university with those practices. Questionnaire data...

Investigating Mechanisms of Injury and Intervention in a Novel In Vitro Model of Traumatic Brain Injury in Organotypic Hippocampal Slice Cultures

Julia Jagielo-Miller
Traumatic brain injuries (TBIs) impact millions of individuals each year and can pose long term consequences. Despite numerous attempts, no medication has been approved by the FDA to treat TBIs. The causes of these failed trials are multifaceted, but in part can be attributed to the complex nature of TBIs, as well as a lack of sufficient pre-clinical data. In vitro models of TBI are an important tool to help understand the cellular changes seen...

An Automated Framework to Debug System-Level Concurrency Failures

Tarannum Shaila Zaman
The ever-increasing parallelism in computer systems has made software more prone to concurrency failures, causing problems during both pre- and post-development. Debugging concurrent programs is difficult because of the non-deterministic behavior and the specific sequences of interleaving in the execution flow. Debugging is a technique where programmers reproduce the bug, identify the root cause, and then take necessary steps to remove the bug from the system. The failure information may come from the bug reports...

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