295 Works

Development of a Field Expedient Screening Tool for the Coach to Identify Musculoskeletal Risk Factors in Baseball Players

Kyle Matsel
Identification of musculoskeletal (MSK) injury risk factors in baseball players can be challenging particularly for youth and high school coaches. Many baseball coaches lack a sports medicine and/or strength and conditioning staff to assist with injury prevention initiatives. Given the extensive responsibilities in managing the team and preparing the players for athletic competition, little time remains to focus on injury prevention and arm care programs. Furthermore, assessment, diagnosis, and management of MSK impairments is outside...

Fostering A Sense of Community Among Teachers Via A Community of Practice

Apryl Clark Moore
Communities of Practice (CoPs) are learning communities that can improve the skills and knowledge of teachers and improve a sense of community. CoPs are designed to cultivate relationships among teachers and develop professional practices that increase a sense of community and knowledge attainment. This study examined the use an online CoP to increase teachers’ sense of community during the COVID-19 global pandemic. Teachers joined a private online community and shared resources about classroom management strategies....

MASS SPECTROMETRY METHOD DEVELOPMENT FOR THE DISCOVERY AND CHARACTERIZATION OF SECONDARY METABOLITES

Zachary Kelley
Secondary metabolites are organic compounds produced by an organism for reasons other than growth and development. In plants, secondary metabolites generally act as defense agents produced to deter predators and inhibit other competitive species. For humans, these compounds can often have a beneficial effect and are pursued and utilized as natural pharmaceuticals. The development of sensitive, high-throughput analytical screening methods for plant derived metabolites is crucial for natural pharmaceutical product discovery and plant metabolomic profiling....

DESIGN, SYNTHESIS, AND ANTICANCER PROPERTIES OF Ru(II) COMPLEXES WITH ORGANOMETALLIC, “EXPANDED” BIPYRIDINE, AND O,O’-CHELATING LIGANDS

Raphael Ryan
Cancer is a worldwide public health crisis that requires new and improved drugs to be developed to extend survival rates and improve quality of life for the patient. Platinum-based drugs are used in approximately 50% of cancer treatment regimens. These drugs are highly effective in many kinds of cancer; however, cancers can develop platinum resistance and these drugs have troubling side effects that reduced their use and efficacy. To overcome these disadvantages, many other metals...

Three Essays on Export Earnings Volatility

Yoonseon Han
My dissertation consists of three essays on export earnings volatility. In the first essay, I look at the determinants of export earnings volatility. The four main determinants suggested by the theoretical literature are export concentration, durability, vertical linkages, and financial vulnerability. A panel of bilateral trade data at the industry level, containing 178 exporting countries, 194 importing countries, and 590 SITC Rev. 1 four-digit industries from 1962 to 2011, is used and these aspects are...

Three Essays in Regional Taxation

Kenneth Tester
This dissertation looks at the role that geographically limited taxation and the behavioral response of economic agents to different forms of regional taxation. While geographic taxation is typically thought to be confined to state and local taxes, federal tax policy can also create designated areas that receive preferential tax treatment. In this dissertation, both types of regional taxation are examined and are unified under common themes such as tax mobility and the definition of the...

QUADRICEPS RECRUITMENT AND TWITCH PROPERTIES IN LEAN AND OBESE WOMEN BEFORE AND AFTER FATIGUING EXERCISE

Rebekah Carpenter
Skeletal muscle strength, specifically that of the anti-gravitational muscles such as the quadriceps, is essential for performing dynamic tasks including walking, navigating stairs, and transitioning between sitting and standing. Obesity has been shown to negatively impact musculoskeletal function and decrease quadriceps strength relative to body weight. Additionally, obesity has been linked with higher rates of fatigue and lower strength outcomes following a test of muscular endurance of the quadriceps. Since obesity lowers relative strength, it...

USE OF MICROSCALE HYDROPHOBIC SURFACE FEATURES FOR INTEGRATION OF 3D CELL CULTURE INTO MULTI-FUNCTIONAL MICROFLUIDIC DEVICES

Soroosh Torabi
3D cell culture and microfluidics both represent powerful tools for replicating critical components of the cell microenvironment; however, challenges involved in integration of the two and compatibility with standard tissue culture protocols still represent a steep barrier to widespread adoption. Here we demonstrate the use of engineered surface roughness in the form of microfluidic channels to integrate 3D cell-laden hydrogels and microfluidic fluid delivery. When a liquid hydrogel precursor solution is pipetted onto a surface...

AN ASSESSMENT OF THE CARRIER STATE AND A NOVEL MARKER OF LEPTOSPIRA AND ABORTION IN CENTRAL KENTUCKY HORSES

Gloria Gellin
Leptospirosis is a reemerging zoonotic infection of worldwide importance and affects all mammals. The bacterium is transmitted to animals and humans by urine, fetal membranes and body fluids. Leptospira shedding in the urine contaminates both soil and water, exposing both humans and animals to the bacterium. Leptospirosis in horses can cause abortion and is one of the etiologies of equine recurrent uveitis which can lead to blindness. Equine leptospiral abortion in Central Kentucky is primarily...

THE EFFECTS OF FORM OF SELENIUM ON THE BOVINE CORPUS LUTEUM, UTERINE ENDOMETRIUM, AND DEVELOPMENT OF THE CONCEPTUS

Benjamin Ryne Crites
Widespread regions of the southeast United States have soils deficient in selenium (Se), necessitating Se supplementation to cattle grazing in these areas. Adequate dietary Se is required for optimal immune function, growth, and fertility. In forages, Se is predominantly found in the organic form (OSe), which is known to increase bioavailability. However, the inorganic form (ISe) is typically found in commercial mineral mixes. We previously reported that supplementation with an isomolar 1:1 mix (MIX) of...

FIRST-GENERATION DOCTORAL STUDENTS’ EXPERIENCES NAVIGATING GRADUATE SCHOOL

Leah Vance-Berg
First-generation students who pursue graduate programs face a unique set of challenges and rely on their strengths to help them navigate their graduate programs. This study will look at how first-generation students have navigated their graduate course work. Semi-structured interviews were conducted with 19 doctoral students at Magnolia University where participants discussed the challenges they have faced during graduate school and how they have navigated these challenges. This exploratory study uses social and cultural capital...

TECHNOLOGY LEADERSHIP PRACTICES OF APPALACHIAN SCHOOL LEADERS DURING THE COVID-19 PANDEMIC

Todd Norton
The COVD-19 pandemic caused a global disruption to education. In some parts of the United States, schools were cancelled for the year, while others shifted their educational offerings to a distance learning model. Kentucky announced short term closures beginning March 13, 2020, but on April 20th the Kentucky Governor announced that schools would not reopen for in-person instruction for the remainder of the academic year. Many school districts quickly developed a plan to continue a...

Epidemiology of Upper Extremity Injuries in High School Sports

Autumn Ruthe Whitson
Participation in high school sports has seen a steady increase over the past four decades. With nearly eight million student-athletes participating, careful monitoring of injuries related to their participation is imperative. Injury surveillance efforts through national databases have produced a multitude of studies detailing injuries that occur in specific sports, specific body parts, or particular diagnoses. The lower extremity tends to be injured more frequently than the upper extremity resulting in various comprehensive analyses on...

SCIENCE-BASED REGULATION OF PHARMACOLOGICAL SUBSTANCES IN COMPETITION HORSES

Jacob Machin
Current testing methodologies within equine forensic toxicology focus on arbitrary thresholds and zero-tolerance policy. Modern analytical chemistry’s limits of detection are low enough that oftentimes femtogram-per-milliliter amounts of a substance can readily be identified in both blood and urine of a horse. For most pharmacologically relevant compounds, these concentrations have no relevance to pharmacological effect. It is therefore crucial that testing methodologies to determine appropriate thresholds and cut-offs be developed that are driven by biological...

“I’m Like Their GPS”

Bonita Tyler
As American community colleges replace prerequisite developmental mathematics courses with corequisite courses, the work of faculty to support underprepared students merits attention. This curricular change means underprepared students are enrolling directly in both college-level content courses with required corequisite support courses for necessary remediation, thus broadening the range of student skills and abilities in the classroom. Faculty work is significantly impacted by this change. Previous research indicates that corequisite course configurations have mitigated some problems...

COLLABORATIVE COMPETITION IN HOMELESS SERVICES

Andrew Sullivan
The United States’ federal government funds homeless services provided at the local level through the McKinney-Vento Act, encouraging collaboration among providers. This dissertation studies three aspects of homelessness: merging of local planning bodies, identification of homeless students, and the relationship between experiencing homelessness in high school and long-term educational outcomes. The first chapter studies the effect of merging Continuums of Care (CoCs), local planning bodies for homeless services. While merging brings organizations into the same...

INTERACTIONS OF POST-PKS ENZYMES OF THE MITHRAMYCIN BIOSYNTHETIC PATHWAY

Ryan Wheeler
Combinatorial biosynthesis is a powerful tool for generating new, more active drug analogues to combat disease. But in order for combinatorial biosynthesis to be employed to its full potential, a deep understanding of the enzymes that produce the parent molecule must be had. The goals of the work presented in this thesis are to characterize the reaction catalyzed by MtmW, the final enzyme in the mithramycin (MTM) biosynthetic pathway, and to discover the interaction between...

ORIENTING NEW INTERNATIONAL COLLEGE STUDENTS DURING A GLOBAL PANDEMIC

Thomas Teague
U.S. colleges must increasingly respond to a wide range of complex forces and simultaneously fulfill their missions and support students. To address many of these forces, some have turned to internationalization efforts like recruiting and enrolling international students. In light of these efforts, critics have called for institutions to better, more appropriately support these students, given their challenges and needs. This call has amplified during the recent COVID-19 global health pandemic. Traditional student support services...

PERIOCULAR MESENCHYME HETEROGENEITY DURING MORPHOGENESIS OF THE VERTEBRATE OCULAR ANTERIOR SEGMENT

Kristyn L. Van Der Meulen
The vertebrate eye is a complex organ, responsible for the primary sense with which we interact with our environment: vision. Development of the eye is a tightly regulated process, controlled by a vast network of genes. This process begins with eye morphogenesis, when the eye structure is formed through a series of morphogenetic movements and culminates in the creation of the optic cup, lens, and presumptive optic stalk. Next, retinal differentiation creates the critical cell...

Faculty Perceptions of Accreditation in the Field of Educator Preparation

Lauren Bell Graves
Accreditation is a measure the federal government, states, and other stakeholders utilize to determine the quality of an institution or a program. Educator preparation providers in Kentucky are required to obtain programmatic accreditation to offer educator preparation programs leading to certification or licensure. The Council for the Accreditation of Educator Preparation (CAEP) is the national accrediting body with which Kentucky has an agreement for joint programmatic accreditation. The Kentucky Education Professional Standards Board (EPSB) adopted...

The Plus-Minus Davenport Constant of Finite Abelian Groups

Darleen Perez-Lavin
Let G be a finite abelian group, written additively. The Davenport constant, D(G), is the smallest positive number s such that any subset of the group G, with cardinality at least s, contains a non-trivial zero-subsum. We focus on a variation of the Davenport constant where we allow addition and subtraction in the non-trivial zero-subsum. This constant is called the plus-minus Davenport constant, D±(G). In the early 2000’s, Marchan, Ordaz, and Schmid proved that if...

SONGS FOR HIGH VOICE

Makeda Hampton
African Romances, Op. 17, composed in 1897 by African-British composer Samuel Coleridge-Taylor (1875-1912), is a collection of seven songs for high voice that is uniquely both African and American. The lyrics of this song cycle were first published in the book Majors and Minors, a collection of poems published in 1895 by Paul Laurence Dunbar (1872-1906). An analysis of resources supports that academic discourse in Black vocal music has been underrepresented due to the absence...

Weight Distributions, Automorphisms, and Isometries of Cyclic Orbit Codes

Hunter Lehmann
Cyclic orbit codes are subspace codes generated by the action of the Singer subgroup Fqn* on an Fq-subspace U of Fqn. The weight distribution of a code is the vector whose ith entry is the number of codewords with distance i to a fixed reference space in the code. My dissertation investigates the structure of the weight distribution for cyclic orbit codes. We show that for full-length orbit codes with maximal possible distance the weight...

Optimization of Gelatin-Based Cellular Coating of MSC for Myocardial Infarction Therapy

Kara Davis
Cardiovascular disease remains the number one threat to American lives. During an acute myocardial infarction (AMI), blood flow is blocked and results in the formation of scar tissue. As the body’s immune system responds, inflammatory signaling causes an increase in both scar tissue size and the patient’s risk for further chronic heart failure. In order to reduce the risk of continued heart disease inflammatory signaling must be reduced. Stem cell therapies have the ability to...

SEXUAL BEHAVIORS ASSOCIATED WITH ONLINE PARTNER-SEEKING AMONG MEN WHO HAVE SEX WITH MEN FROM SMALL/MIDSIZED TOWNS OR RURAL AREAS IN KENTUCKY

Vira Pravosud
The HIV epidemic remains one of the most significant public health issues in the United States, particularly among men who have sex with men (MSM). New avenues for partner-seeking have emerged over the past three decades, including through the Internet, social media, and geosocial networking applications. Consisting of three cross-sectional studies, this dissertation research aimed to determine associations between the use of various online tools for partner-seeking (hereafter collectively referred to as “apps”) and HIV-related...

Registration Year

  • 2021
    295

Resource Types

  • Dissertation
    295

Affiliations

  • University of Kentucky
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