2,796 Works

Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation

Timothy M. Rooney

Flipping Biological Switches: Solving for Optimal Control: A Dissertation

Joshua TsuKang Chang

Sensing of Endogenous Nucleic Acids by the Innate Immune System during Viral Infection: A Dissertation

Stefan A. Schattgen

A More Accessible Drosophila Genome to Study Fly CNS Development: A Dissertation

Hui-Min Chen

Characterization of Envelope-Specific Antibody Response Elicited by HIV-1 Vaccines: A Dissertation

Yuxin Chen

GLI-IKBKE Requirement In KRAS-Induced Pancreatic Tumorigenesis: A Dissertation

Mihir S. Rajurkar

Neural Orchestration of the C. elegans Escape Response: A Dissertation

Christopher M. Clark

Role of Hdac3 in Murine Coronary Vessel Development: A Master's Thesis

Kevin M. Smee

Evolutionary Approaches to the Study of Small Noncoding Regulatory RNA Pathways: A Dissertation

Alfred T. Simkin

Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation

Belinda Barbagallo

Differences in Access to Care and Healthcare Utilization Among Sexual Minorities: A Master's Thesis

Tan Phu Pham

Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation

Kimberly A. Negrin

Studies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation

Liusong Yin

Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation

Ozge E. Tasdemir-Yilmaz

Implementation and Utilization of Mobile Technology In Adolescent Bariatric Surgery Patients

Jonathan Green, Jeremy T. Aidlen, Sherry L. Pagoto & Jennifer Bram
Obesity is the most prevalent chronic disease of childhood. Obese adolescents are likely to become obese adults with significant associated co-morbidities and early mortality. In Massachusetts, 30% of children ages 10-17 are overweight or obese. It is projected that 48% of Massachusetts’ adults will be obese by 2030. In March of 2015, the Good Fit Adolescent Weight and Wellness Center opened, with a goal of addressing this issue with a proven multidisciplinary approach. Mobile technology...

Long-lasting Effects of Perinatal Exposure to Brominated Flame Retardant on Male Reproductive Outcomes in Rat Model

Ahmed Khalil, Daneal Portman, Jake Jensen, Michael Panchenko & Alexander Suvorov
Meta-analysis of 101 studies published between 1934 and 1996 indicates that mean sperm concentration decreased around 50% during this period. More recent studies have found alarmingly poor semen quality in the general population of Northern Europe. Additional adverse trends include increased incidence of testicular cancer, and congenital malformations such as cryptorchidism and hypospadias. Testicular germ cell cancers increased by about 400% over the period of 50 years in industrialized countries. Decreased quality of male reproductive...

Effective Pain Information Pre-operatively is Associated with Improved Functional Gain after Total Joint Replacement

Celeste A. Lemay, David Ayers & Patricia D. Franklin
Objective: We evaluated receipt of pre-operative pain management education in a national prospective cohort on post-operative pain and function. Methods: Preoperative, 2 week and 6 month postoperative data from a nationally representative cohort of 1404 primary unilateral TJR patients with a date of surgery between May 2011 and December 2014. Data included demographics, comorbid conditions, operative joint pain severity (HOOS/KOOS), musculoskeletal disease burden, physical function (SF36 PCS), and mental health (SF36 MCS). At 2 weeks...

Terpenes as ‘resistance-busting” anthelmintic drug

Zeynep Mirza, David Koch, Thanh-thanh Nguyen, Yan Hu, Raffi V. Aroian & Gary R. Ostroff
There is an urgent need for new therapies for parasitic helminthic diseases affecting 1.5-2 billion people worldwide due to the threat of wide-spread resistance development to existing treatments and due to problems of incomplete efficacies. Terpenes are plant secondary metabolites and major essential oil constituents. Historically, the terpene thymol was successfully used to cure hookworm infections in the 1900’s. Although effective, large doses were needed and thymol treatment had significant side effects. Because free terpenes...

Human monoclonal antibodies to Plasmodium falciparum circumsporozoite protein for transient passive protection of malaria travelers to endemic areas

Stuart Nelson, Douglas Golenbock, Ann M. Moormann, Colby A. Souders & Lisa Cavacini
Plasmodium falciparum, is a protozoa that causes over 214 million cases of Malaria worldwide and the World Health Organization reported an estimated 438,000 deaths attributed to malaria in 2015. Current prevention strategies have reduced malaria cases but they are either costly, have poor efficacy or resistance has begun to develop. There is a global need for an effective pre-exposure prophylaxis treatment. The leading Malaria vaccine candidate is RTS,S which contains a monovalent Plasmodium falciparum circumsporozoite...

Predisposed Health Conditions of Children Exposed to Methamphetamine In Utero

Seth Peters
Methamphetamine (MA) use and abuse is a growing problem worldwide [United Nations World Drug Report]. It is common knowledge that MA use affects not only the user, but also friends, family, and the communities close to them [NIDA]. One area of impact that is lacking sufficient study is the effects of MA use by expectant mothers on her child later in life. That is to say, a child who was exposed to MA in utero...

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  • University of Massachusetts Medical School