1,260 Works

Identification of MHC-Associated Peptides and Phosphopeptides Presented in Various Diseased Cells by Tandem Mass Spectrometry

Xi Peng
Major histocompatibility complex (MHC) class I and II molecules are involved in the presentation of antigens to T cells, which can initiate an immune response upon recognition of abnormal peptide sequences and modifications. Specifically, phosphopeptides resulting from aberrantly increased protein phosphorylation in cancer are proposed as potential cancer-specific targets for developing novel immunotherapeutic treatments. However, it remains as a challenge to accurately identify these peptide sequences and to localize modification sites due to factors including...

Surveillance and Vendor Data Panel, University of Virginia Library

Brandon Butler, Timothy Morton, Ellen Ramsey, Robin Ruggaber & Judith Thomas
The University of Virginia Library presented this Surveillance and Vendor Data Panel discussion via Zoom on November 8, 2021. Shoshana Zuboff, professor emerita at Harvard Business School, warns that the conveniences of on demand digital information have made us blind and deaf to the ways high-tech giants exploit our personal data for their own ends. In her book, “The Age of Surveillance Capitalism,” Zuboff picks up on her argument that surveillance capitalism, a term she...

Compton Polarimetry for Neutral Weak Form Factor Measurements in 208Pb and 48Ca

Allison Zec
Atomic nuclei contain a number of protons and neutrons. Most heavy nuclei contain more neutrons than protons in order to remain stable. The nuclear proton distribution can be measured via elastic scattering of charged particles, but the neutron distribution remains poorly constrained. Nuclear structure theory also predicts a "neutron skin" ΔRnp where the mean radii of neutrons in the nucleus exceeds that of protons. Two experiments were run in 2019 and 2020 to measure the...

Examining Metabolism in Seagrass Meadows: Trends in Respiration and Non-Dissolved Gas Ebullition

Ieva Juska
Seagrass meadows provide many valuable ecosystem services, including carbon sequestration and storage of ‘blue carbon’. Enhancing carbon cycling through seagrass restoration can thus act as a nature-based solution for climate change, as these ecosystems naturally remove carbon dioxide from the atmosphere through their high rates of productivity. Estimated metabolic values such as Gross Primary Productivity (GPP), Respiration (R), and Net Ecosystem Metabolism (NEM) are used in quantifying in situ carbon sequestration in seagrass meadows and...

Leveraging Proteomic Strategies to Analyze Post-Translational Modifications and Membrane Proteins

Maria Panepinto
This dissertation details three projects that apply tandem mass spectrometry to analyze purified proteins. There are three strategies that can be used to approach proteomic analysis: intact, limited digestion, and traditional digestion. All three of these projects are unified in that at least two of these strategies was required to achieve their goal. This dissertation demonstrates that these approaches are much more powerful and provide more information in combination than they do alone. The first...

The Illusion of Unfairness

Remy Furrer
Valuing control over their lives, people struggle with the notion that their fate is often determined by random events. Despite such aversion to randomness, for millennia, human beings have resorted to using random processes for the purpose of distributing benefits and burdens amongst themselves in a fair manner. In this experiment, I explore the notion that people are so attuned to maintaining control over their fate that they may see unfairness in random negative outcomes...

Cyber-Physical Systems and National Security

Enkhbilig Batsukh
This thesis portfolio is comprised of research into the cyberphysical systems that define the global economy, from the consumer appliance to defense technology networks. On a societal scale, many Americans utilize cyberphysical systems as a matter of course – few consider the level of integration these tools have achieved to be particularly abnormal. Computerized control systems have contributed to the development of a vast array of devices that simplify or enhance everyday life from smart...

Nemesis: Rendering (In)Justice in Latin America and the Caribbean

Karina Baptista
“Nemesis: Rendering (In)Justice in Latin America and the Caribbean” is a study of the variegated ways in which writers and filmmakers in Latin America and the Caribbean engage with retributive justice, and more broadly, with the idea of Nemesis. The texts analyzed are the short story “Monstro” by Dominican American writer Junot Díaz; Una sombra donde sueña Camila O’Gorman, the only work of prose by the Argentinian poet Enrique Molina; a selection of short stories...

Opa protein mediated interactions with human neutrophils affect Neisseria gonorrhoeae survival

Allison Alcott
Neisseria gonorrhoeae (Gc) is the causative agent of the sexually transmitted infection gonorrhea. If left untreated, gonorrhea infections can lead to serious health sequelae including infertility and pelvic inflammatory disease. Gc infection in a human host elicits a potent immune response characterized by a robust recruitment of neutrophils to the site of infection. Despite the immune response, Gc uses a variety of mechanisms to evade killing by neutrophils, allowing for sustained infection, and for viable...

Group phenotypic composition shapes emergent network structures and selection regimes in Bolitotherus cornutus

Phoebe Cook
A social network is the set of interactions or associations between all individuals in a population. The position an individual holds within its network modulates exposure to grooming, social information, parasites, and disease. Group social structures themselves are also thought to be adaptive. But we understand little about the causes of variation between groups, both in overall network structures and in the evolutionary pressures acting on network position. My dissertation work explored how the composition...

A Systems Analysis of Policymaking for Climate Adaptation in Coastal Virginia

Mohammad Sadegh Eghdami Fateh Abadi
The impacts of climate change have sparked policy responses at different governance levels. Studying the central adaptation policies and understanding the interactions and complexities of governmental and non-governmental stakeholders is essential in guiding local, regional, and state stakeholders to formulate policies and make investment decisions. With strategic and economic significance on the national level, Coastal Virginia has one of the highest rates of sea-level rise in the United States, instigating intensified and more frequent climate...

Evaluation of Publicly-Available Global Hydrologic Datasets to Improve Water Resources Management in Vietnam

Manh Hung Le
Water resources management (WRM) is essential to sustainably improve prosperity in developing nations. WRM requires reliable estimates of key hydrometeorological variables to monitor changes in water availability. Thus, one of the biggest challenges in WRM at the national scale is accurate and timely observations of these variables from the ground networks (referred to as local datasets) that usually have low density. Without boundary restriction and global coverage, satellite-based and outputs from land surface models datasets...

Program Evaluation: Clinical Nurse Specialist Led Program for Diabetes Health

Elizabeth Kassulke
The increasing prevalence of diabetes in the United States indicates that healthcare providers will likely encounter patients in the acute care setting with a diagnosis of diabetes, even if that is not the chief complaint or medical concern that led to the hospital admission. A systematic literature search shows that Advanced Practice Nurses (APRNs) deliver care that is comparable to physician colleagues in meeting target blood glucose levels. Utilizing the Agency for Clinical Innovation’s (ACI)...

Intimate Partner Violence Assessment Program Evaluation

Susanna Pruangkarn
Intimate partner violence (IPV) refers to the violence or patterns of abusive behaviors between intimate partners with 17 % of men and 33 % of women experiencing IPV (Ahmed et al., 2017). Despite the prevalence of IPV in the general population, compliance with national standards for IPV screening is inconsistent. Surprisingly, only 66 % of hospitals across the US screen for IPV in their EDs (Delgado et al., 2011). The purpose of this project was...

HEDGE Hypersonic ReEntry Deployable Glider Experiment; Unmanned Aerial Vehicles for Commercial use: Ethical Impacts on Privacy

Samantha Castro
The technical report within this portfolio consists of a detailed proposal to the Department of Defense or the National Aeronautics and Space Administration for support of a hypersonic reentry deployable glider CubeSat experiment. The project began during the scholastic year 2021-2022 with a team of fifteen, each divided into six sub system component groups and will be completed in the year 2025 with deployment. This scholastic year began the design process of the hypersonic deployable...

Shock-Ionized Jets from Massive Protostars; The Loss of Dark Night Skies: How Cultural and Scientific Advocates are Pushing Back

Emiko Gardiner
While my technical project focused on processing and analyzing simulation data, the simulated results would be unenlightening without telescope observations with which to compare them. I post-processed snapshot data from a 3D magnetohydrodynamic simulation of a massive protostellar outflow to predict observables and compare them to observations and theory. In all sciences, theorists can develop and simulate self-consistent models of phenomena, but without experimental results, there is no way to validate these models. Astronomy is...

Piedmont Virginia Community College Site Design; Reframing Societal Interpretation to Overcome the Stereotypes Surrounding Community College in America

Abby Herrod
Engineers tend to focus a lot of their resources and knowledge on the technical side of the world. Diving deep into the minute details that make something work. Rarely is it the first thought of an engineer to determine, understand, and analyze the social implications of such technical designs. It goes without saying that most technical operations or projects also have a correlating impact on society and the world outside of mechanics. It is important...

Enhancing Product Support Software; Evaluating Current Satellite Internet Technologies’ Impact on Internet Equality

Matthew Bulk
My technical project examines my experience working at ST Engineering iDirect as a software engineering intern. ST Engineering iDirect produces ground-based infrastructure for satellite communication networks. Satellite communication networks play a large and ever-growing role in daily global communications and provide vital internet connectivity to isolated locations. In recent years, demand for low latency and high-bandwidth network connections has driven the development of low Earth orbit satellite communication constellations. Given the importance for individuals who...

Hydroponic Crop Cultivation as a Strategy for Reducing Food Insecurity

Alexander Boland
This project hopes to serve as both a study and as a guide for designing new crop cultivation techniques in an environmentally-uncertain future. The technical portion of this project is a part of a bigger Capstone, in which a floating hydroponic farm was designed to withstand a category 3 hurricane. This project is by far not an end all-be-all for farming in the Caribbean, but it does introduce a stepping stone for adapting agriculture to...

Fetch Mobile Manipulator – Programming Link Lab’s First Personal Robot; Investigation of Sociotechnical Relationships between Autonomous Robots and Humans

Utkarsh Chirimar
People perform mundane tasks on a daily basis. These mundane tasks include stacking chairs, organizing rooms, erasing whiteboards, folding laundry, etc. These tasks all hold great importance, but they take up a lot of time and effort. Mundane tasks have a lasting effect on human beings. It has been proven that mundane tasks cause psychological distress on people. One solution to this problem is to develop autonomous robots that can accurately perform simple human tasks....

The Implications of the Lack of Translation Services on the Globalization of Biomedical Research;Understanding and Predicting Temperature Distribution of Hospital Sink Tailpiece Heaters

Alisa Houghton
This portfolio contains two projects, a technical project on creating a computational model of heat distribution to aid in the redesigning of hospital tailpiece heaters and a sociotechnical paper investigating how the lack of accessible translation services impacts the globalization of biomedical research. The idea for the sociotechnical paper was birthed during my experience of finding background information for the technical project. I constantly ran into articles with promising, relevant information in abstracts written in...

Design and Implementation of Power Walker Related Experimentation; How Changes in Music Technology Have Impacted the Industry and Society

Taylor Kagie
What do walking and music have in common? Other than relating them through dancing or making a pun involving songs about walking, there is very little to relate the technical and STS projects presented in this portfolio. However, there is a connection: they both center around my personal interest and inability to focus on only one topic when I have the opportunity to discuss both. Beginning with the technical report, my motivation lies within a...

Active Control of Wind Turbine Blades to Increase Efficiency; Energy Generation Technology and the Marginalization of Low-Income and Underserved Communities

Amanda Kassebaum
As the demand for energy increases, it is important that more electricity is generated from clean sources of energy in order to mitigate the effects of climate change. This thesis portfolio contains the procedures and results of two separate research projects both related to the generation of electricity. The STS research paper discusses the socioeconomic and environmental effects of three different energy sources: coal, nuclear power, and lithium-ion batteries. The technical project solely focuses on...

Information Technology Internship at Ingalls Shipbuilding; The Effects of Anime and Social Media on Western Consumer Culture

Jennifer Khuu
Anime and social media have grown rapidly over the past few years, and as both continue to grow, there will continue to be an increase in the number of anime-related content on social media as well as the number of anime and social media influencers. The final science, technology, and society (STS) deliverable analyzes the social and political causes that led to the rise of anime in the West as well as the social and...

The Development and Evaluation of a Shallow Ground Loop Design for Ground Source Heat Pumps (GSHPs); The Role of Socio-Cultural Influences on Electric Vehicle Adoption in the Modern American Market

Kara Koopman
Climate change is often considered the defining crisis of the 21st century. The world is running out of time to reduce greenhouse gas (GHG) emissions and constrain global warming enough to avoid truly catastrophic damage. This portfolio examines challenges to the adoption of two emerging sustainable technologies – ground source heat pumps and electric vehicles – which have the potential to greatly reduce emissions. Ground source heat pumps (GSHPs) are more efficient than traditional systems...

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  • 2022
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