Clostridioides difficile, the causative agent of the most common hospital-acquired gastrointestinal infection, has been labeled an urgent health threat by the CDC. Despite readily available antibiotic therapy, C. difficile is responsible for approximately 500,000 infections and 29,000 deaths in the US each year. Increases in the rates of C. difficile infection (CDI) in recent decades have been linked to the emergence of epidemic, hypervirulent strains. While typical strains of C. difficile express only the primary...