584 Works

FastGSK: Fast and Efficient Sequence Analysis Using Gapped String Kernels

Derrick Blakely
String kernel methods achieve strong classification performance on DNA, protein, and natural language data using modestly-sized training sets. However, existing kernel function algorithms suffer from slow kernel computation times, as they depend exponentially on the sub-sequence feature length and the task's alphabet size. In this work, we introduce a new string kernel algorithm using gapped k-mers called FastGSK. Compared to previous string kernels, it uses a simplified kernel algorithm that decomposes into a set of...

Gender Differences in Friendship Quality Across Adolescence

Alida Davis
It is often assumed that adolescent girls are more socially adept than their male counterparts. However, the question of whether adolescent girls’ and boys’ close friendships differ in quality is largely unexplored in the literature. The present study aims to address this question by characterizing the development of boys’ and girls’ friendship quality across seven years of adolescence, from the ages of 13 to 19. A community sample of 184 adolescents (53% female) and their...

Innovating in War: Risk, Organizational Cost and Successful Adoption

Rafael Lopez
Why do military organizations often fail to adopt innovation in wartime even when it promises to increase military effectiveness? To answer the question, a theory was developed focusing on a gap in the literature for military diffusion. While theories for explaining the decision to adopt are well represented, less work exists to explain implementation. The theory, agent-led adoption, argues that in cases where implementation within the parent military is led by a special purpose suborganization,...

Genetic Diversity and Spatial Structure of Spartina alterniflora at Four Spatial Scales

Janet Walker
Spartina alterniflora, salt marsh cordgrass, is the dominant plant in coastal wetlands along the North American Atlantic coast. Ecological disturbances in salt marshes, such as coverage by wrack, disease, and eat-outs, affects Spartina marshes from the Gulf of Mexico to New England and may reduce the diversity of S. alterniflora clones within a population or alter other genetic characteristics of a population by eliminating some genotypes. Nine polymorphic microsatellite loci were used to quantify the...

Secondary Mathematics Teachers' Curricular Reasoning and Adaptations of Pacing Guides

Nicole Fratrik
This study investigates teachers' curricular reasoning when adapting pacing guides for use in the secondary mathematics classroom. Through interviews and observations, I found that secondary mathematics teachers value common pacing guides. Experienced teachers often make adaptations to pacing guides provided by the district or even write their own pacing guides.

DNA Methylation of the Oxytocin Receptor Gene Maps Increases in Conditioned Learning Rates at the Late Positive Potential

Andrew Graves
Associative learning is a fundamental building block of information acquisition. Organisms learn from environmental cues to detect signals that predict reward or punishment, and update beliefs on how to respond accordingly. Demands on the human brain are uniquely complex, requiring advanced abilities to recognize, manipulate and respond to socially relevant information. This includes the ability to construct representations of environmental contingencies predicting safety and threat. Individual differences contribute to the ability to flexibly learn and...

Dynamic Assembly of the Type-3 Secretion System in Yersinia enterocolitica Probed by Super-Resolution Fluorescence Imaging.

Julian Rocha
The bacterial Type III Secretion System (T3SS) is a complex membrane spanning molecular machine comprised of over 20 different proteins. The T3SS is employed by pathogenic bacterial species to deliver effector proteins though a hollow needle-like structure, providing the mechanism of eukaryotic host cell infection. While effector proteins differ between species, the structural components of the T3SS remain largely conserved, making the machinery an attractive drug target. However, how secretion substrates are selected and transported...

The Migration of Hot Jupiters and our Outer Planets

Jeremy Lawson
Our understanding of planetary migration has greatly increased since the discovery of exoplanets. A few decades ago, we had little to no knowledge of exoplanets, and our understanding of planetary migration came from the eight planets that are in our solar system. In this paper I will discuss various methods planets migrate and how they settle into stable orbits. I will also discuss some interesting examples of planetary migration such as the migration of the...

An Overview of Formamide Based Nucleosynthesis and Exoplanetary Candidates for Associated RNA Auto-Syntheses

Amrita Singh
This paper comes in two parts; first an analysis and overview of the RNA World theory, formamide-based nucleic acid synthesis, and how formamide fits into and even furthers the theory, and second an exploration of the Kepler Exoplanets Catalogue to determine candidates for prebiotic synthesis. The mere term "RNA World" brings up much of controversy within the realm of the origins of life, but it is the strongest abiogenesis theory, if given a few updates....

Registration Year

  • 2019

Resource Types

  • Text


  • University of Virginia