235 Works

Effect of fetal sex on glucose outcomes in a bovine model

Colby Vorland
Fetal sex may influence the metabolic state of the dam (i.e., male fetuses may increase the risk for gestational diabetes mellitus; ‘fetal drive’), an observation known to livestock biologists. To our knowledge, the true causal relationship of this hypotheses has not been tested by randomly assigning animals to different conditions. Such research, apart from being interesting from an evolutionary biology perspective, may increase understanding of mechanisms relating to maternal and fetal health, miscarriage rates, and...

Allergien: Sensibilisierung durch Permethrin in Textilien ist unwahrscheinlich

Scaling of preferences for different liquids by means of binary choice tests in mice.

Lars Lewejohann
The overall aim is to develop a scaling, which allows to rate certain goods against each other in order to conduct severity assessment for future animal experiments. In this experiment mice will choose between various liquids that will be tested against each other in binary preference tests. The preference will be measured by means of a modified two bottle choice test which will be conducted in the IntelliCage. The tested liquids are 10 mM HCl,...

Identifying and reducing boredom symptoms in experimental animals – systematic behavioral monitoring

Kai Diederich
Boredom is described by psychologists as an unpleasant feeling of insufficient stimulation accompanied by a perceived inability to break out of this adverse situation. Laboratory Animals may experience boredom as a result of the restrictive environment in standard animal housing. Standard laboratory housing can lead to forced inactivity, since standard cages provide limited space and few cognitive stimuli. These conditions might lead to chronic boredom which in turn severely affects the wellbeing of the animals....

Non-technical Summaries (NTS) of Animal Experiments Indexed with ICD-10 Codes (Version 1.0)

Mariana Neves, Daniel Butzke, Antje Dörendahl, Nora Leich, Barbara Grune & Gilbert Schönfelder
Dataset containing 8,386 non-technical summaries (NTS) of animal experiments recently carried out in Germany (as of September 19, 2018) and originally on-line available at the AnimalTestInfo database (http://animaltestinfo.de). Each NTS contains a title, uses (goals) of the experiments, possible harms caused to the animals, and comments about replacement, reduction and refinement (in the scope of the 3R principles). All documents are in the German language. The dataset includes the ICD-10 codes manually assigned by experts...

Exemplary study for Animal Study Registry “Dose-response curve for buprenorphine in mice”

Juliane Rudeck
Preamble: This study serves as an exemplary exploratory study for Animal Study Registry which was already carried out in 2016. Opioids are the treatment of choice for moderate to severe perioperative pain in mice. Among the numerous opioid drugs available, buprenorphine is the preferred analgesic due to its long-lasting effect and little adverse side effects. Vast differences in recommendations for dosage, application route and application intervals lead to uncertainties in the appropriate administration and counteract...

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