238 Works

miRNA profile of extracellular vesicles isolated from bone marrow following in vivo irradiation

Katalin Lumniczky
Male C57Bl/6 mice were irradiated with low and high dose X-ray irradiation. Mice were sacrificed 24 hours later and bone marrow-derived extracellular vesicles were isolated and microRNAs prepared. A miRNA profiling was performed by Exiqon (Vedbaek, Denmark), using qPCR panel with the miRNA Ready-to-Use PCR, Mouse&Rat panel I+II using ExiLENT SYBR® Green master mix. The amplification was performed in a LightCycler® 480 Real-Time PCR System (Roche) in 384 well plates The amplification curves were analysed...

German Thorotrast Study (human data)

Mandy Birschwilks
There are data from four different animal studies with Thorotrast from the years 1975 - 1989 in rats.The study tracks key data, study design, number of animals, a list of responsible scientist and some references are already in the ERA database.Institution: Deutsches Krebsforschungszentrum, Heidelberg, Germany.Purpose: To determine the respective roles of the radioactive and chemical component in Thorotrast gel-induced tumours, alpha radioactivity in Thorotrast was enriched about 50 times by addition of Th-230.Thorotrast was the...

Late somatic effects in mice after fractionated X-ray and neutron exposure

Michael Gruenberger
Purpose: To determine the dose rate reduction factor and RBE for X-ray and neutron exposure. Status: 1987- ongoing Treatment: Single exposure to 250 kVp X-rays (318 mGy/min, 1.5 mm HVL) and single and fractionated (5 fractions at one day interval) exposure to fission neutrons (0.4 MeV, 4 mGy/min) from the biological facility of the RSV-TAPIRO reactor at Casaccia Dosimetry: Twin ionization chamber method, ENDIP Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Male (C57Bl/Cne...

Myeloid leukaemia and malignant lymphoma in mice after X-ray and neutron exposure

Michael Gruenberger
Purpose: To determine neutron RBE for myeloid leukemia and malignant lymphoma. Status: 1980 - 1984, terminated Treatment: Single exposure to 250 kVp X-rays (133 mGy/min, 1.5 mm HVL) or fission neutrons (4 mGy/min, 0.4 MeV) from the biological facility of the RSV-TAPIRO reactor at Casaccia. Dosimetry: Twin ionization chamber method, ENDIP Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Male (C57Bl/Cne x C3H/Cne)F1 (BC3F1) mice aged 3 months Results: The data on the induction...

Tumours and survival in mice in dependence of age after X-ray and neutron exposure

Michael Gruenberger
Purpose: To determine the RBE in function of the age of the animal. Status: 1984 - 1989, terminated Scientists: V. Di Majo; M. Coppola; S. Rebessi; V. Covelli; Treatment: Single exposure to 250 kVp X-rays (133 mGy/min, 1.5 mm HVL) or fission neutrons (4 mGy/min, 0.4 MeV) from the biological facility of the RSV-TAPIRO reactor at Casaccia Dosimetry: Twin ionization chamber method, ENDIP Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: (C57Bl/Cne x C3H/Cne)F1...

Low-dose radiation differentially regulates protein acetylation and histone deacetylase expression in human coronary artery endothelial cells

Zarko
Ionizing radiation induces cardiovascular disease, the endothelium being the main target. The exact mechanism of the damage is unclear but the involvement of multiple signaling pathways is probable. Reversible lysine acetylation is a posttranslational protein modification that regulates activity across a broad range of signaling pathways. The goal of this study was to determine if a low radiation dose (0.5 Gy) results in acetylome alteration in a human coronary artery endothelial cell line. Nearly a...

Wick Data

Michael Gruenberger
Ra-224 patients treated for ankylosing spondylitis; Germany

Japan ApoE proteomics

Stefan J. Kempf
null

CEREBRAD VMB

Stefan J. Kempf
null

CEREBRAD in vitro and in vivo brain

Stefan J. Kempf
HT22 cells were irradiated with 0 Gy, 0.5 Gy, 1.0 Gy and 4.0 Gy follwed by mass spectrometry-based analysis 4 hours and 24 hours post irradition. NMRI mice were irradiated with 0 Gy or 1 Gy followed by mass spectrometry-based analysis 24 hours post irradiation using whole cortex and hippocampus

CEREBRAD hippocampus cortex NMRI

Stefan J. Kempf
null

Budapest

Stefan J. Kempf
null

Local high-dose cardiac irradiation induces disturbed energy metabolism associated with impaired PPAR alpha activity in C57BL/6 mice

Omid Azimzadeh
Radiation exposure is associated with a markedly increased risk of cardiac morbidity and mortality with a latency period of several decades. Although different studies have confirmed the damaging effect of ionizing radiation on the myocardium and cardiac endothelial structure and function, the molecular mechanism is not yet fully elucidated. Peroxisome proliferator-activated receptor alpha (PPAR alpha), a transcriptional regulator of lipid metabolism in the heart tissue, has recently received great attention in the development of cardiovascular...

High-dose ionising radiation affects TGF beta and PPAR alpha signalling pathways 40 weeks after local heart irradiation in C57BL/6J mice

Omid Azimzadeh
Epidemiological data from radiotherapy of thoracic and chest wall tumours show the damaging effect of ionising radiation on heart and vasculature. The long-term impairment of heart function and structure after local high-dose irradiation in mice is associated with systemic inflammatory response, contraction impairment, microvascular damage and cardiac fibrosis. The goal of the present study was to investigate molecular mechanisms involved in this process. C57BL/6J mice received X-ray doses of 8 and 16 Gy locally to...

TEST

Michael Gruenberger
TEST ONLY

SUBI tritium exposed Wistar rats

Bernd Grosche
Information on data and biological material from 224 Wistar rats held at Southern Urals Biophysics Institute of the Federal Medical Biological Agency Ozyersk, Russian Federation Responsible scientists: Eduard Lubchansky, Olga Kuzmenko, Valentina Revina Background The information was gathered from 224 Wistar rats that were used in SUBIs experiment no. 76323. The collection and collation of the information was done as part of Task 4.8 of the previous EURATOM-funded project DoReMi (Integrating Low Dose Research) [European...

SUBI tritium exposed Wistar rats

Bernd Grosche
Information on data and biological material from 224 Wistar rats held at Southern Urals Biophysics Institute of the Federal Medical Biological Agency Ozyersk, Russian Federation Responsible scientists: Eduard Lubchansky, Olga Kuzmenko, Valentina Revina Background The information was gathered from 224 Wistar rats that were used in SUBIs experiment no. 76323. The collection and collation of the information was done as part of Task 4.8 of the previous EURATOM-funded project DoReMi (Integrating Low Dose Research) [European...

Tumours and Lifespan in Rats After Gamma Irradiation At Different Ages

Michael Gruenberger
Purpose: To determine the effects of age and the dose rate reduction factor for external gamma irradiation. Status: 1982-1990, terminated, data in ERAD Treatment: Exposure to a low dose rate Co-60 gamma source at different ages and dose rates Dosimetry: Ionization chamber Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Sprague-Dawley SPF rats of both sexes Results: Epidemiological studies so far did not reveal an increase in cancer incidence among people occupationally exposed to...

Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells

Omid Azimzadeh
Radiation is a highly efficient therapy in squamous head and neck carcinoma (HNSCC) treatment. However, local recurrence and metastasis are common complications. Recent evidence shows that cancer-cell-derived exosomes modify tumour cell movement and metastasis. In this study, we link radiation-induced changes of exosomes to their ability to promote migration of recipient HNSCC cells. We demonstrate that exosomes isolated from irradiated donor cells boost the motility of the HNSCC cells BHY and FaDu. Molecular data identified...

Single Dose Fe Ion Irradiation Highlights the Radiation Quality Dependent Nature of the Endothelial Cell Response to Ionizing Radiation Exposure

Omid Azimzadeh
Background and Purpose. Radiotherapy is an essential tool for cancer treatment. In order to spare normal tissue and to reduce the risk of normal tissue complications, particle therapy is a method of choice. Although a large part of the healthy tissue can be spared due to improved depth dose characteristics, little is known about the underlying biological and molecular mechanisms of particle irradiation in healthy tissues, such as the vasculature. Elucidation of these vascular effects...

Tumours and Lifespan in Rats After Treatment with Chemicals

Michael Gruenberger
Purpose: To evaluate the induction or promotion effect of inhalation (or injection) alone and together with -naphthoflavone as promotor. Status: 1977 - 1985, terminated; data in ERAD Treatment: Various chemicals inhaled or injected as indicated on the table Dosimetry: Amounts inhaled or injected Endpoints: Life-span study (spontaneous death) with macroscopic/microscopic pathology Animal: Male Sprague-Dawley SPF rats at an age of 3 months; for untreated controls see 02.01, controls treated with BNF only see 02.04 Results:...

Effects of Prenatal and Postnatal Gamma Irradiation on the Rat Testis

Michael Gruenberger
Purpose: To determine the effect of acute irradiation during gestation and the neonatal period and of protracted exposure during the entire intra-uterine life on adult rat testis: influence of dose rate and threshold values. Status: 1977 - 1988, terminated Treatment: Acute and protracted Co-60 gamma irradiation: acute exposure to doses from 0 to 1.5 Gy at different dose rates on day 15 and 21 of gestation and day 0 and 2 of postnatal life. A)...

Single Dose Fe Ion Irradiation Highlights the Radiation Quality Dependent Nature of the Endothelial Cell Response to Ionizing Radiation Exposure

Omid Azimzadeh
Background and Purpose. Radiotherapy is an essential tool for cancer treatment. In order to spare normal tissue and to reduce the risk of normal tissue complications, particle therapy is a method of choice. Although a large part of the healthy tissue can be spared due to improved depth dose characteristics, little is known about the underlying biological and molecular mechanisms of particle irradiation in healthy tissues, such as the vasculature. Elucidation of these vascular effects...

3-generation Exposure Study

Paul Schofield
The Semipalatinsk nuclear test site (STS) is located approximately 150 km west of the city of Semipalatinsk (now called Semey), and was a major site for nuclear weapons testing by the former Soviet Union. It was here that the Soviet Union conducted their first nuclear test on 29 August 1949. Later, 465 nuclear explosions were carried out between 1949 and 1989, including 118 atmospheric events (88 air events and 30 surface events) from 1949-1962. The...

EPI-CT scan cohort

Paul Schofield
EPI-CT is a multinational cohort study of children and young adults who have undergone at least one computed tomography (CT) scan before the age of 22 years. It comprises three main parts: 1) an epidemiological cohort study assessing cancer effects of radiation exposure from CT; 2) a dosimetry system to evaluate individual doses and related uncertainty, and supporting dose reduction and optimisa on strategies; 3) a pilot study to evaluate the feasibility of applying diferent...

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