62,715 Works

Long-term outcome after implantation of a nickel-containing cemented hip stem on the right in a patient with type IV sensitization to nickel sulphate

Sarah Armonies, Dirk Zajonz, Regina Treudler, Andreas Roth & Mohamed Ghanem
Type IV allergies to nickel sulfate, potassium dichromate and/or cobalt chloride are supposed to be associated with aseptic loosening, pain or infections in patients with hip arthroplasty. However, there is debate on any causal relation between type IV sensitization to metals and any of these complications. We report on a patient with suspicion of pre-existing type IV sensitization to nickel sulfate and potassium dichromate who did not show any complications after hip arthroplasty.
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Potential users of visual prosthesis: expectations, motivation and attitudes towards participation

Vasiliki Karadima & J. S. Pezaris
Objective: To describe patient views toward visual prostheses, along with perceived risks and benefits about emerging neuro-technology clinical trials. Materials and methods: Subjects were 38 blind individuals (20 F/18 M) recruited through The Lighthouse of Greece. An information session about[for full text, please go to the a.m. URL]
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The challenge to meet the expectations of patients, ophthalmologists and public health care systems with current retinal prostheses

Eberhart Zrenner, R. Rubow & A. Stett
Since 1995 a subretinal implant for blind patients with retinitis pigmentosa has been developed in Germany, first supported by public research funds and as of 2003 by private investors. After 3 clinical trials (Zrenner et al. 2011; Stingl et al. 2015, 2017) the RETINA IMPLANT Alpha AMS with 1600 pixel[for full text, please go to the a.m. URL]
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Towards a unified set of performance outcomes for vision restoration trials

Gislin Dagnelie, A. Kartha, R. Sadeghi, C. Bradley & D. Geruschat
Objective: The work of the HOVER taskforce has demonstrated that the need, and the ability, to reach consensus about common instruments to measure outcomes in vision restoration trials. Still, the resulting range of tests is large and diverse, and further consolidation may be possible. In view of [for full text, please go to the a.m. URL]
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Object recognition training with simulated retina implant perception

Stefan Pollmann, C. Nath & L. Wang
Objective: We used training experiments with simulated retina implant (RI) perception to investigate how object recognition can be improved for RI-patients. We first investigated the efficiency of different retrieval schedules. In two more experiments, we investigated training transfer across tasks.[for full text, please go to the a.m. URL]
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Perception of motion in a 2nd generation suprachoroidal retinal implant

Samuel A. Titchener, M. A. Petoe, J. Kvansakul, M. N. Shivdasani, J. B. Fallon, D. A .X. Nayagam, S. B. Epp, C. E. Williams, N. Barnes, W. G. Kentler, M. Kolic, E. K. Baglin, C. J. Abbott, C. D. Luu & P. J. Allen
Purpose: To determine whether perception of motion is achievable with a 2nd generation suprachoroidal retinal implant. Methods: Three participants (PA, PB, PC) implanted with a 44-channel suprachoroidal retinal implant performed a 4AFC motion discrimination task. Stimuli were a single white vertical[for full text, please go to the a.m. URL]
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The effect of eye and head position on reading speed in a simulation of prosthetic vision

Nadia Paraskevoudi & J. S. Pezaris
Objective: Visual scanning is important in perceiving the world, but is challenging for artificial vision. Two approaches have resulted, devices which adapt stimulation based on gaze position, so that the point of regard can be steered with eye motion, and those that do not, and are usually steered [for full text, please go to the a.m. URL]
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A model of sight ın artificial vision and some of its perception properties

Kazim Hilmi Or
Objective: Many subtypes of vision (biologic, human, machine, computer, artificial etc) are scientifically described. Visual perception itself cannot be decribed by science. Materials and methods: The subtypes of vision are explained with the relatiıon to artificial vision. The perception [for full text, please go to the a.m. URL]
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A suprachoroidal retinal prosthesis: initial functional results

Penelope J. Allen, D. A. X. Nayagam, C. D. Luu, N. Barnes, M. Kolic, K. Young, E. K. Baglin, C. J. Abbott, R. J. Briggs, J. Yeoh, W. G. Kentler, J. Kvansakul, S. A. Titchener, M. A. Petoe & C. E. Williams
Objective: The success of our prototype clinical trial (NCT01603576) of a suprachoroidal retinal prosthesis led us to develop a second generation fully implantable device, with the aim of providing visual information to profoundly visually impaired patients (NCT03406416). We believe that enabling the[for full text, please go to the a.m. URL]
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Improvement in reading performance through training with simulated thalamic visual prostheses

Katerina Eleonora K. Rassia & J. S. Pezaris
Objective: Psychophysical tasks have been used with simulations of artificial vision viewed by normal sighted subjects to evaluate performance and help guide device design, but with little attention paid to learning effects. We examined the effects of training when reading through a simulated visual[for full text, please go to the a.m. URL]
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Implantation of microchips in the relay neurons of the lateral geniculate nucleus

Walter Gallo Gomez & Y. Pecho Trigueros
The project involves the implantation of microchips in the relay neurons of the lateral geniculate nucleus. The chips are radio frequency receivers and demodulators and deliver a potential capable of depolarizing neurons. The chips are of the passive type (their energy originates the same wave they[for full text, please go to the a.m. URL]
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Towards the development of a micro-coil based cortical visual prosthesis

Shelley Fried, S. W. Lee & S. B. Ryu
Objective: We are developing a cortical visual prosthesis that uses magnetic stimulation (instead of electrical) to drive cortical neurons. This approach is attractive because the induced fields from coils are spatially asymmetric and therefore, can activate local pyramidal neurons while avoiding passing[for full text, please go to the a.m. URL]
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Development of a cortical visual neuroprosthesis for the blind: preliminary results in human

Eduardo Fernandez
Objective: Cortical prostheses are a subgroup of visual neuroprostheses capable of evoking visual percepts in profoundly blind people through direct electrical stimulation of the occipital cortex. This approach may be the only treatment available for blindness caused by glaucoma, end-stage retinal degenerations,[for full text, please go to the a.m. URL]
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The Newcastle optogenetic visual cortical prosthesis

Yu Liu & P. Degenaar
Objective: To describe the efforts of the Newcastle visual cortical prosthesis – our system design and optogenetic probes. Materials and methods: The Newcastle visual cortical prosthesis consists of three parts: A headset, a subcutaneous control unit, and a brain implant unit. A headset [for full text, please go to the a.m. URL]
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Newcastle visual cortical prosthesis

Patrick Degenaar, Y. Liu & A. Soltan
Optogenetics is a gene therapy technique which holds lots of potential as a neural interface but also has lots of challenges. It is currently under trial both in the US and Europe for use in a retinal prosthesis form of visual restoration for those with Retinitis Pigmentosa. These trials have been underway[for full text, please go to the a.m. URL]
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12 months results of first in human study, implanting the wireless sub-retinal PRIMA microchip in patients with dry AMD

Yannick Le Mer, S. Mohand-Saïd, M. Muqit, J. Sahel & D. Palanker
Purpose: The Prima system, including a wireless subretinal photovoltaic microchip, is designed for restoration of central vision in patients blinded by retinal degeneration while preserving the residual peripheral field. Minimal invasive surgical implantation technique was designed to make sub retinal[for full text, please go to the a.m. URL]
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Surgical technique of the PRIMA photovoltaic retinal implant: from animal testing to implantation in humans

Mahi M.K. Muqit, J. P. Hubschman, S. Picard, D. B. McCreery, J. C. van Meurs, C. Nouvel-Jaillard, C-M. Fovet, P. Hantraye, J. Sahel, J. N. Martel & Y. Le Mer
Objective: To develop a surgical method for the implantation of a subretinal photovoltaic retinal implant. Materials and methods: Cats and Macaca fascicularis primates with healthy retina underwent vitrectomy surgery and were implanted with subretinal wireless photovoltaic microchip at the macula/central[for full text, please go to the a.m. URL]
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Management of surgery-associated adverse events of Argus II retinal prosthesis system

Kim Schaffrath, T. Lohmann, S. Baumgarten, H. Schellhase & P. Walter
Objective: Retinal degenerative diseases, e.g. retinitis pigmentosa, could lead to loss of vision and blindness. Treatment is still limited, but a new possibility to improve vision in late-state disease is implanting epiretinal prostheses, p.e. Argus II retinal prosthesis (Second Sight Medical Products,[for full text, please go to the a.m. URL]
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First Belgian Argus II retinal prosthesis implantation and rehabilitation: one-year outcomes

Caroline Van Cauwenbergh, D. Nerinckx, L. Spielberg, L. Hebbelinck, A. Vandesteene, E. Van De Ginste, W. Schrauwen, I. Joniau, L. Wouters & B. P. Leroy
Objective: To evaluate the surgical procedure and rehabilitation outcomes of the first Belgian Argus II Retinal Prosthesis System implantation in a patient with end-stage retinitis pigmentosa. Materials and methods: Surgical procedure included suture of extraocular components onto the sclera, and[for full text, please go to the a.m. URL]
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A suprachoroidal retinal prosthesis: surgical safety and stability

Penelope J. Allen, D. A. X. Nayagam, S. B. Epp, C. D. Luu, N. Barnes, M. Kolic, K. Young, E. K. Baglin, C. J. Abbott, R. J. Briggs, J. Yeoh, W. G. Kentler, S. A. Titchener, M. A. Petoe & C. E. Williams
Objective: The success of our prototype clinical trial (NCT01603576) of a suprachoroidal retinal prosthesis led us to develop a second generation fully implantable device, with the aim of providing visual information to profoundly visually impaired patients. Materials and methods: Four patients[for full text, please go to the a.m. URL]
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44-channel suprachoroidal retinal prosthesis clinical trial: interim device status update 1 year post-implantation

David A.X. Nayagam, M. A. Petoe, S. A. Titchener, M. Kolic, E. K. Baglin, C. J. Abbott, C. D. Luu, S. B. Epp, P. Thien, J. Kvansakul, M. N. Shivdasani, W. G. Kentler, O. Burns, J. Villalobos, R. Millard, P. Seligman, J. Yeoh, R. J. Briggs, R. K. Shepherd, C. E. Williams & P. J. Allen
Purpose: To evaluate the functionality and mechano-electrical stability of our suprachoroidal retinal prosthesis (SRP) in clinical trial participants. Methods: 4 patients were implanted with a generation-2 SRP (Feb-Aug, 2018; ClinicalTrials.gov:NCT03406416). The implant had 44 platinum electrodes[for full text, please go to the a.m. URL]
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Dynamics of pupillary responses to sinusoidal transcorneal electrostimulation in healthy subjects – Effects of stimulus frequency

Ronja Jung, K. Stingl, K. Stingl, C. Kelbsch, H. Wilhelm, T. Peters, B. Wilhelm, T. Strasser & P. Richter
Objective: The purpose of this project was to evaluate the potential of electrically-induced pupil responses as an objective parameter for the function of retinal neurons. In particular, the pupillary reactions to diverse stimulation frequencies were analyzed to investigate the possibility of cell-specific[for full text, please go to the a.m. URL]
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Surgical in vivo model in rabbits to test chronically self-opening intra-neural electrodes for optic nerve stimulation

Martina Kropp, D. Ghezzi, A. Conti, C. Jonescu-Cuypers & G. Thumann
Objective: To develop a surgical technique in rabbits for the controlled chronic intra-orbital implantation to test self-opening intra-neural electrodes for optic nerve stimulation. Materials and methods: The surgical procedure was developed in 13 New Zealand White Rabbits. To define the surgical[for full text, please go to the a.m. URL]
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Electrical Stimulation of the optic nerve for neuroprosthetic applications

Vivien Gaillet, A. Cutrone, F. Artoni, P. Vagni, A.M. Pratiwi, S.A. Romero Pinto, D. Lipucci Di Paola, S. Micera & D. Ghezzi
Objective: To evaluate the ability of a 12-channels intra-neural electrode (OpticSELINE) to selectively stimulate different portions of the optic nerve, and to develop a computational model that would allow predicting in silico the selectivity of the stimulation. Materials and methods: The OpticSELINE[for full text, please go to the a.m. URL]
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Feasibility of 3rd generation suprachoroidal-transretinal stimulation (STS) prosthesis in healthy dogs

Takeshi Morimoto, T. Miyoshi, T. Saitoh, K. Ito, M. Ozawa, K. Nishida & T. Fujikado
Purpose: To investigate the feasibility of implanting 3rd generation suprachoroidal–transretinal stimulation (STS) prosthesis in healthy dogs. Methods: Six healthy dogs were used in this study. The STS prosthesis consisted of 49 electrodes. The array was implanted into a scleral pocket of[for full text, please go to the a.m. URL]
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Registration Year

  • 2008
    3
  • 2009
    4,713
  • 2010
    4,402
  • 2011
    6,022
  • 2012
    5,709
  • 2013
    6,094
  • 2014
    6,096
  • 2015
    6,659
  • 2016
    6,464
  • 2017
    6,304
  • 2018
    5,014
  • 2019
    5,232

Resource Types

  • Text
    62,715