158 Works

Acrylamide – Addendum for re-evaluation of the BLW and evaluation of EKA and BAR

Thomas Göen


o-Toluidine – Evaluation of a BAR

Elke Ochsmann



Andrea Hartwig &

Importance of sex-specific factors in the establishment of BAT values

Hermann Maximilian Bolt

Hydrogen fluoride and inorganic fluorine compounds (fluorides) – Addendum for re-evaluation of the BAT value

Pia Lämmlein

Manganese and its inorganic compounds – Addendum for re-evaluation of the BAT value and evaluation of a BAR

Michael Bader

5.4.2. Psychoonkologie

Ute Berndt
Kapitel des Online Lehrbuch der Medizinischen Psychologie und Medizinischen Soziologie

Recurrent uncomplicated urinary tract infections: definitions and risk factors

Tommaso Cai
Introduction: Recurrent uncomplicated urinary tract infections (UTI) have a high impact on patients’ quality of life and high direct and indirect costs for public health. Therefore, optimal management should be of high priority. Methods: Current international guidelines were reviewed, and a systematic literature search was performed in Medline, Cochrane, and Embase. Results: Several risks factors have been identified and used in everyday clinical practice to plan the correct strategy for recurrence prevention. Among all factors,...


Andrea Hartwig &

2.8.3. Biopsychosoziale Zusammenhänge bei Verdauungsstörungen und chronischen viszeralen Schmerzen

Sigrid Elsenbruch & Sven Benson
Kapitel im Online Lehrbuch der Medizinischen Psychologie und Medizinischen Soziologie

Sulphur hexafluoride (SF6) tracer technique

Yvanne Rochette, Arjan Jonker, Peter Moate, Amélie Vanlierde & Cécile Martin
A further method for measuring methane production is the sulphur hexafluoride (SF₆) tracer technique, which requires inserting a known quantity of the inert tracer into the rumen. The use of the SF₆ tracer technique to quantify enteric CH4 emissions from grazing ruminants was pioneered by Zimmerman and Johnson. The SF₆ tracer technique is an indirect method to quantify CH4 emissions from ruminants because only a representative quantity of gas produced by the animal is collected;...

7‑Hydroxycitronellal – Bestimmung von 7‑Hydroxycitronellylsäure in Urin mittels UPLC‑MS/MS

Markus Stöckelhuber, Gerhard Scherer, Thomas Jäger, Thomas Göen, Andrea Hartwig &

Identification of influence factors on the quality and shelf life of fresh meat throughout the supply chain

Antonia Albrecht & Lucas Correa Dresch
Due to the industrialization and globalization of food production, food supply chains became increasingly complex, which led to a multitude of steps that products must pass during production, processing and distribution. At the same time, the quality standards and requirements for shelf life were raised in order to allow for the most efficient delivery and exploitation of the sales period of fresh products, especially for meat. During the supply, meat is exposed to several environments...

Healthcare-associated urinary tract infections in urology

José Medina-Polo, Kurt Georg Naber & Truls Erik Bjerklund Johansen
The purpose of the present review is to report the incidence and characteristics of healthcare-associated urinary tract infections (HAUTIs) in urology with their microbiological and resistance patterns. Urinary tract infections are the main type of healthcare-associated infection in patients hospitalized in a urology ward. Patients admitted to urology departments report a high prevalence of urinary tract catheterization, up to 75% during the hospitalization period, and up to 20% had a urinary catheter before admission. An...

Biomarkers in children with kidney diseases

Angela Ciuntu & Jana Bernic
Novel biomarkers are used to facilitate the early diagnosis, timely treatment, and prognosis of renal pathology in children. Technological progress on the one hand and a remarkable clinical significance of biomarkers on the other hand are subjects of scientific and clinical value. In spite of marked progress in this field, sensitivity and specificity of novel biomarkers represent a concern that is still prevailing. Furthermore, the identification of a perfect biomarker is of particular importance and...

Kresol (alle Isomere) – Addendum: Reevaluierung von BLW und BAT-Wert

Albert Rettenmeier, Hans Drexler, Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated cresol (all isomers) [1319-77-3] and evaluated a maximum workplace concentration (MAK value) of 1 ml cresol/m3. Only one study has been published in which the relationship between external exposure to cresol and cresol excretion in urine was investigated. However, the time-weighted average of external exposure in this study was far below the current MAK value. Data on...

Dichlormethan, Trichlormethan, Tetrachlormethan, 1,2‑Dichlorethan, 1,1,1‑Trichlorethan, Trichlorethen und Tetrachlorethen – Bestimmung von chlorierten Kohlenwasserstoffen in Blut mittels Headspace‑GC-MS

Thomas Göen, Johannes Müller, Bernd Roßbach, Kerstin Lüddens-Dämgen, Thomas Göen, Andrea Hartwig &
The working group “Analyses in Biological Materials“ of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and verified the presented biomonitoring method.The analytical method described herein allows the simultaneous determination of dichloromethane, trichloromethane, tetrachloromethane, 1,2‑dichloroethane, 1,1,1‑trichloroethane, trichloroethene, and tetrachloroethene in blood. For determination, the blood samples are filled into sealed headspace sample vials and heated to 50 °C in a headspace-autosampler. Afterwards, an aliquot is...

Aluminium silicate fibres (refractory ceramic fibres, RCF)

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated aluminium silicate fibres considering all toxicological endpoints. Aluminium silicate fibres cause mesotheliomas and lung tumours in rats and hamsters. In epidemiological studies, cancer risk was not associated with exposure to aluminium silicate fibres. Tumour formation in animals is a result of chronic inflammation; therefore, aluminium silicate fibres are a candidate for Carcinogen Category 4. However, the re-evaluation...


Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated monomethylhydrazine [60-34-4] considering all toxicological end points. The acute toxicity of monomethylhydrazine is caused by depletion of gamma-aminobutyric acid leading to the effects on the central nervous system. Chronic and subchronic exposure induces haemolytic effects and adverse effects on the liver. In carcinogenicity studies, inhaled monomethylhydrazine caused tumours of the lungs, liver, blood vessels and olfactory epithelium...


Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated methyl chloride [74-87-3], considering all toxicological end points. Critical effects are neurotoxicity and reduced fertility. The NOAEC for adverse effects on fertility in male rats after 3-month exposure was 150 ml/m. A NAEC of 100 ml/mfor reduced fertility in male rats was estimated from a 2-year study.The NOAEC for degenerations of the cerebellar granular layer is 150...

Ethics in experiments on live cattle: a pragmatic approach

Isabelle Veissier, Véronique Deiss, Mette Herskin, Emer Kennedy & Kenny Rutherford
There are ongoing philosophical, moral, and societal debates about experiments on live animals. Along with a consequentialist approach, it may be considered that an action – here an experiment on live animals – is morally acceptable if the knowledge it aims to produce can result in an overall benefit. In other words, it is acceptable if the constraints imposed on the animals involved are outweighed by the larger benefits expected for others (humans or animals)....

A checklist to validate sensor output for the recording of cattle behaviour

Matthieu Bouchon, Alex Bach, Bruno Meunier, Emma Ternman, Kees Van Reenen, Isabelle Veissier & Lene Munksgaard
A process of validation assesses the appropriateness and usefulness of a tool for its intended purpose within a specific context. Ideally, the validation of a tool should describe the range of purposes and contexts in which it is appropriate. This generally cannot be done completely. Therefore, when such a wide validation cannot be done, the validation process needs to refer clearly to the purpose of the use of the tool and to which animals it...

Behavioural tests

Emma Ternman, Guilherme Amorim Franchi & Lene Munksgaard
o answer specific questions regarding cow behaviour or affective states, it is sometimes necessary to study the cow’s responses to specific stimuli in a test situation. This can be done either in the animal’s home environment or in a test arena. As specific research questions determine the test design, it is not possible to provide a general guideline that fits all types of behavioural test. However, there are several considerations common for most behaviour tests...

Registration Year

  • 2021

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  • Jena University Hospital
  • University Hospital in Halle
  • Hospital Universitario 12 De Octubre
  • Technical University of Munich
  • Ospedale Santa Chiara
  • Oslo University Hospital
  • Witten/Herdecke University
  • University Hospital Heidelberg
  • Heinrich Heine University Düsseldorf
  • Essen University Hospital