158 Works

Selen und seine anorganischen Verbindungen – Addendum zur Ableitung von BAR

Annette Greiner, Hans Drexler, Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated biological reference values (BAR) for selenium [7782-49-2] in plasma and in urine to characterise the internal exposure. Selenium is an essential trace element, which is incorporated in considerable amounts by nutrition. Occupational exposure can lead to an additional selenium uptake. Its metabolism and distribution behaviour are complex. In plasma most selenium is bound to proteins and demonstrates...

Gadolinium – Evaluierung von Untersuchungsergebnissen in biologischem Material

Bernhard Michalke, Hans Drexler, Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the background concentration of gadolinium [7440-54-2] in occupationally not exposed persons of the general population without gadolinium application for magnetic resonance imaging (MRI, MRT measurements). Available publications are described in detail. In total, only few publications on the background exposure to gadolinium could be found, some of which used different analytical methods and different sample matrices (urine,...

Cresyl glycidyl ethers (o-isomer, isomer mixture)

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated cresyl glycidyl ethers (o-isomer [2210-79-9], mixture of isomers [26447-14-3]) considering all toxicological end points. The critical effect of cresyl glycidyl ethers is skin sensitization in humans and animals. In rats, local irritation is observed after inhalation. Cresyl glycidyl ethers are a direct mutagen in bacteria and the mutagenicity is considerably reduced by adding S9-mix. In Big Blue...

Geraniol – Determination of 8‑carboxygeraniol, Hildebrandt acid, geranic acid, and 3‑hydroxycitronellic acid in urine by UPLC‑MS/MS

Thomas Jäger, Sandra Bäcker, Thomas Brodbeck, Michael Bader, Gerhard Scherer, Markus Stöckelhuber, Thomas Göen, Andrea Hartwig &
The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and verified the presented biomonitoring method.The method described herein enables the selective and quantitative determination of geraniol metabolites in human urine into the concentration range relevant for environmental exposure. The following four metabolites can be determined using this method: 8‑carboxygeraniol, Hildebrandt acid, geranic acid, and 3‑hydroxycitronellic acid. Hildebrandt acid,...

Formic acid methyl ester

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated the maximum concentration at the workplace (MAK value), the Pregnancy Risk Group and the germ cell mutagenicity of formic acid methyl ester [107-31-3]. No neurobehavioral effects were observed in subjects exposed to 100 ml/m3 for 8 hours at rest. After taking the increased respiratory volume at the workplace into account because the blood:air partition coefficient of formic...

Lindane

Andrea Hartwig &

Lysmeral – Determination of hydroxylysmerylic acid, 4-tert-butylbenzoic acid, tert-butylhippuric acid, lysmerylic acid, and lysmerol in urine by UPLC-MS/MS

Gerhard Scherer, Nadine Rögner, Gerhard Gilch, Dusan Krnac, Markus Stöckelhuber, Nikola Pluym, Max Scherer, Susanne Gerling, Katharina Blümlein, Thomas Göen, Andrea Hartwig &
The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and verified the presented biomonitoring method.With the procedure described below, the following lysmeral metabolites are determined in urine: hydroxylysmerylic acid, 4‑tert‑butylbenzoic acid (TBBA), tert‑butylhippuric acid (TBHA), lysmerylic acid, and lysmerol. Following the addition of the deuterated internal standards (TBBA‑d 13 , lysmerylic acid‑d 8 , and lysmerol‑d 8 )...

Lysmeral – Bestimmung von Hydroxylysmerylsäure, 4-tert-Butylbenzoesäure, tert-Butylhippursäure, Lysmerylsäure und Lysmerol im Urin mittels UPLC-MS/MS

Gerhard Scherer, Nadine Rögner, Gerhard Gilch, Dusan Krnac, Markus Stöckelhuber, Nikola Pluym, Max Scherer, Susanne Gerling, Katharina Blümlein, Thomas Göen, Andrea Hartwig &
The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and verified the presented biomonitoring method.With the procedure described below, the following lysmeral metabolites are determined in urine: hydroxylysmerylic acid, 4‑tert-butylbenzoic acid (TBBA), tert-butylhippuric acid (TBHA), lysmerylic acid, and lysmerol. Following the addition of the deuterated internal standards (TBBA‑d 13 , lysmerylic acid‑d 8 , and lysmerol‑d 8 )...

Registration Year

  • 2021
    158

Resource Types

  • Text
    108
  • Journal Article
    49
  • Other
    1

Affiliations

  • Jena University Hospital
    3
  • University Hospital in Halle
    3
  • Hospital Universitario 12 De Octubre
    2
  • Technical University of Munich
    2
  • Ospedale Santa Chiara
    1
  • Oslo University Hospital
    1
  • Witten/Herdecke University
    1
  • University Hospital Heidelberg
    1
  • Heinrich Heine University Düsseldorf
    1
  • Essen University Hospital
    1