49 Works

Chlormethan

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated methyl chloride [74-87-3], considering all toxicological end points. Critical effects are neurotoxicity and reduced fertility. The NOAEC for adverse effects on fertility in male rats after 3-month exposure was 150 ml/m. A NAEC of 100 ml/mfor reduced fertility in male rats was estimated from a 2-year study.The NOAEC for degenerations of the cerebellar granular layer is 150...

Kresol (alle Isomere) – Addendum: Reevaluierung von BLW und BAT-Wert

Albert Rettenmeier, Hans Drexler, Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated cresol (all isomers) [1319-77-3] and evaluated a maximum workplace concentration (MAK value) of 1 ml cresol/m3. Only one study has been published in which the relationship between external exposure to cresol and cresol excretion in urine was investigated. However, the time-weighted average of external exposure in this study was far below the current MAK value. Data on...

Dichlormethan, Trichlormethan, Tetrachlormethan, 1,2‑Dichlorethan, 1,1,1‑Trichlorethan, Trichlorethen und Tetrachlorethen – Bestimmung von chlorierten Kohlenwasserstoffen in Blut mittels Headspace‑GC-MS

Thomas Göen, Johannes Müller, Bernd Roßbach, Kerstin Lüddens-Dämgen, Thomas Göen, Andrea Hartwig &
The working group “Analyses in Biological Materials“ of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area developed and verified the presented biomonitoring method.The analytical method described herein allows the simultaneous determination of dichloromethane, trichloromethane, tetrachloromethane, 1,2‑dichloroethane, 1,1,1‑trichloroethane, trichloroethene, and tetrachloroethene in blood. For determination, the blood samples are filled into sealed headspace sample vials and heated to 50 °C in a headspace-autosampler. Afterwards, an aliquot is...

Aluminium silicate fibres (refractory ceramic fibres, RCF)

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated aluminium silicate fibres considering all toxicological endpoints. Aluminium silicate fibres cause mesotheliomas and lung tumours in rats and hamsters. In epidemiological studies, cancer risk was not associated with exposure to aluminium silicate fibres. Tumour formation in animals is a result of chronic inflammation; therefore, aluminium silicate fibres are a candidate for Carcinogen Category 4. However, the re-evaluation...

Monomethylhydrazin

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated monomethylhydrazine [60-34-4] considering all toxicological end points. The acute toxicity of monomethylhydrazine is caused by depletion of gamma-aminobutyric acid leading to the effects on the central nervous system. Chronic and subchronic exposure induces haemolytic effects and adverse effects on the liver. In carcinogenicity studies, inhaled monomethylhydrazine caused tumours of the lungs, liver, blood vessels and olfactory epithelium...

Di(2‑propylheptyl) phthalate – Determination of mono(2‑propyl-6‑carboxyhexyl) phthalate, mono(2‑propyl-6‑hydroxyheptyl) phthalate, and mono(2‑propyl-6‑oxoheptyl) phthalate in urine by GC-HR-MS or GC-MS/MS

Wolfgang Gries, Christoph Schmidtkunz, Gabriele Leng, Michael Müller, Martina Lange, Thomas Göen, Andrea Hartwig &

o-Phenylphenol (OPP) – Bestimmung von o-Phenylphenol in der Luft am Arbeitsplatz mittels Hochleistungsflüssigchromatographie (HPLC-DAD)

George Dragan, Ralph Hebisch, Adela Frenzen, Lutz Nitschke, Andrea Hartwig &
This analytical method is a validated measurement procedure for the determination of o-phenylphenol [90-43-7] in workplace air in a concentration range of one tenth up to twice the currently valid occupational exposure limit in Germany of 5 mg/m3. For sampling a defined volume of air is drawn through a binder-free quartz fibre filter followed by a silica gel sorbent tube. The flow rate is set to 1 l/min and sampling duration is 2 hours (which...

Toluol – Addendum: Evaluierung einer Schwangerschaftsgruppe zu den BAT-Werten

Wobbeke Weistenhöfer, Gerlinde Schriever-Schwemmer, Hans Drexler, Andrea Hartwig &
In 2020, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated toluene [108-88-3] regarding reproductive and developmental toxicity. Provided the maximum workplace concentration (MAK value) of 50 ml/m3 is observed, prenatal toxic effects are not to be expected. Toluene was therefore classified in Pregnancy Risk Group C in 1993, which was confirmed in 2020. The biological tolerance values (BAT values) of 600 µg toluene/l blood, 75 µg...

Methanol – Addendum: re-evaluation of the BAT value

Patricia Kreis, Britta Brinkmann, Hans Drexler, Andrea Hartwig &
In 2018, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has lowered the maximum concentration at the workplace (MAK value) for methanol [67-56-1] to 100 ml/m3. The biological tolerance value (BAT value) was correlated to the MAK value. Therefore, the BAT value has to be re-evaluated. After 8-hour exposure of test persons to 100 ml methanol/m3 with physical activity, a concentration of 15 mg methanol/l urine was...

1,1-Dimethylhydrazin

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated 1,1-dimethylhydrazine [51-14-7] considering all toxicological end points. The acute toxicity of 1,1-dimethylhydrazine is caused by depletion of gamma-aminobutyric acid leading to the effects on the central nervous system. During chronic and subchronic exposure, adverse effects on the blood, liver, nervous system, colon and spleen were observed in dogs and adverse effects on the liver and colon were...

Kohlenmonoxid – Addendum zur Reevaluierung des BAT-Wertes

Britta Brinkmann, Rüdiger Bartsch, Christoph van Thriel, Hans Drexler, Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated the biological tolerance value (BAT value) of carbon monoxide (CO) [630-08-0]. Exercising healthy test persons became significantly faster exhausted at CO exposures resulting in a CO-Hb content of 3.35 to 5.1%. This was only observed with very high physical activity (minute volume of 100 l/min) which is much higher than that assumed to be realistic in workplaces...

Dichloroacetic acid and its salts

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated dichloroacetic acid [79-43-6] to derive a maximum concentration at the workplace (MAK value) and to review its carcinogenicity classification. The critical effects are irritation, carcinogenicity in the liver of rats and mice as well as neurotoxicity. After oral application, dichloroacetic acid or its sodium salt has tumour-promoting effects and is carcinogenic in the liver of rats and...

Triphenylphosphat

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated triphenyl phosphate [115-86-6] considering all toxicological end points. Triphenyl phosphate is not neurotoxic in hens and rats and not irritating to the eyes and skin of rabbits. In a 13-week toxicity study with rats, hepatocellular hypertrophy and follicle cell hypertrophy in the thyroid gland started to be not adversly induced at a triphenyl phosphate dose of 105...

Gadolinium – Evaluation of study results in biological material

Bernhard Michalke, Hans Drexler, Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the background concentration of gadolinium [7440-54-2] in occupationally not exposed persons of the general population without gadolinium application for magnetic resonance imaging (MRI). Available publications are described in detail.In total, only few publications on the background exposure to gadolinium could be found, some of which used different analytical methods and different sample matrices (urine, blood, serum). Gadolinium...

Pigment Yellow 12, Pigment Yellow 13, Pigment Yellow 83

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated Pigment Yellow 12 [6358-85-6], Pigment Yellow 13 [5102-83-0] and Pigment Yellow 83 [5567-15-7] considering all toxicological end points. Depending on their intended use, the pigments are produced in different sizes with a d50 ranging from 15 to 250 nm. In technical applications, particles smaller than 100 nm are called nanoparticles. By definition, pigments are not soluble in...

Toluene – Addendum: evaluation of a pregnancy risk group for the BAT value

Wobbeke Weistenhöfer, Gerlinde Schriever-Schwemmer, Hans Drexler, Andrea Hartwig &
In 2020, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area evaluated toluene [108-88-3] regarding reproductive and developmental toxicity. Provided the maximum workplace concentration (MAK value) of 50 ml/m3 is observed, prenatal toxic effects are not to be expected. Toluene was therefore classified in Pregnancy Risk Group C in 1993, which was confirmed in 2020. The biological tolerance values (BAT values) of 600 µg toluene/l blood, 75 µg...

Cresol (all isomers) – Addendum: re-evaluation of BLW and BAT value

Albert Rettenmeier, Hans Drexler, Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated cresol (all isomers) [1319-77-3] and evaluated a maximum workplace concentration (MAK value) of 1 ml cresol/m3. Only one study has been published in which the relationship between external exposure to cresol and cresol excretion in urine was investigated. However, the time-weighted average of external exposure in this study was far below the current MAK value. Data on...

Methanol

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated the maximum concentration at the workplace (MAK value) of methanol [67-56-1] of 200 ml/m3, considering all toxicity endpoints. Available publications and unpublished study reports are described in detail. Uptake of larger amounts of methanol depresses the central nervous system and leads to developmental toxicity as direct effects of methanol followed by metabolic acidosis and ocular toxicity as...

1,1,1-Trichloroethane

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of 1,1,1-trichloroethane [71-55-6]. Critical are pre-narcotic effects observed in male volunteers exposed at rest to 350 ml/m3. The MAK value has now been lowered to 100 ml/m3 taking into account the increased respiratory volume at the workplace because the blood:air partition coefficient of 1,1,1-trichlorethane...

2-Methyl-2-propanthiol

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated data for 2-methyl-2-propanethiol [75-66-1] considering all toxicological end points. Data from a 90-day inhalation study with rats show that the critical effect of 2-methyl-2-propanethiol is its haematotoxic potential. On the basis of the NOAEC of 9 ml/m and taking into account the increased respiratory volume at the workplace, the maximum concentration at the workplace (MAK value) has...

Dichloroacetic acid and its salts

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the developmental toxicity of dichloroacetic acid [79-43-6] and its salts. In 2019, a maximum concentration at the workplace (MAK value) of 0.2 ml/m, corresponding to 1.1 mg/m, was set for dichloroacetic acid. Accordingly, a MAK value of 1.1 mg/m for the inhalable fraction, measured as the acid, has been set for the salts. The critical effects are...

O,O,O-Triphenylmonothiophosphat

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated O,O,O-triphenylmonothiophosphate [597-82-0] considering all toxicological end points. O,O,O-triphenylmonothiophosphate is not neurotoxic in hens and rats and not irritating to the eyes and skin of rabbits. In an oral 13-week toxicity study with rats, increased liver weights and hepatocellular hypertrophy in addition to follicle cell hypertrophy and altered colloid in the thyroid gland were observed at 200 mg/kg...

n-Decyl oleate

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated n-decyl oleate [3687-46-5], considering all toxicological end points. Available publications and unpublished study reports are described in detail. As with white mineral oil, inhalation of aerosols of the hardly water-soluble n-decyl oleate could result in overload in the lung, inflammatory reactions and microgranulomas. To prevent this overload, a maximum concentration at the workplace (MAK value) of 5...

Di(2‑propylheptyl)phthalat – Bestimmung von Mono(2‑propyl-6‑carboxyhexyl)phthalat, Mono(2‑propyl-6‑hydroxyheptyl)phthalat und Mono(2‑propyl-6‑oxoheptyl)phthalat in Urin mittels GC‑HR‑MS oder GC‑MS/MS

Wolfgang Gries, Christoph Schmidtkunz, Gabriele Leng, Michael Müller, Martina Lange, Thomas Göen, Andrea Hartwig &

(4-Nonylphenoxy)acetic acid

Andrea Hartwig &
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated (4-nonylphenoxy)acetic acid [3115-49-9] considering all toxicological end points. Available publications and unpublished study reports are described in detail. In a combined repeated dose toxicity study with the reproduction / developmental toxicity screening test in rats, (4-nonylphenoxy)acetic acid led to hyperplasia of the forestomach at 60 mg/kg body weight and day. Effects on fertility and developmental toxicity were...

Registration Year

  • 2021
    49

Resource Types

  • Journal Article
    49