Estimating microtubule distributions from 2D immunofluorescence microscopy images reveals differences among human cultured cell lines.

Jieyue Li, Aabid Shariff, Mikaela Wiking, Emma Lundberg, Gustavo Rohde & Robert Murphy
Microtubules are filamentous structures that are involved in several important cellular processes, including cell division, cellular structure and mechanics, and intracellular transportation. Little is known about potential differences in microtubule distributions within and across cell lines. Here we describe a method to estimate information pertaining to 3D microtubule distributions from 2D fluorescence images. Our method allows for quantitative comparisons of microtubule distribution parameters (number of microtubules, mean length) between different cell lines. Among eleven cell...
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