Fabrication and in vivo thrombogenicity testing of nitric oxide generating artificial lungs.

Kagya A. Amoako, Patrick J. Montoya, Terry C. Major, Ahmed B. Suhaib, Hitesh Handa, David O. Brant, Mark E. Meyerhoff, Robert H. Bartlett & Keith Cook
Hollow fiber artificial lungs are increasingly being used for long-term applications. However, clot formation limits their use to 1-2 weeks. This study investigated the effect of nitric oxide generating (NOgen) hollow fibers on artificial lung thrombogenicity. Silicone hollow fibers were fabricated to incorporate 50 nm copper particles as a catalyst for NO generation from the blood. Fibers with and without (control) these particles were incorporated into artificial lungs with a 0.1 m(2) surface area and...
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