Fabrication and in vivo thrombogenicity testing of nitric oxide generating artificial lungs.

, Patrick J. Montoya, Terry C. Major, Ahmed B. Suhaib, , David O. Brant, Mark E. Meyerhoff, Robert H. Bartlett & Keith Cook
Hollow fiber artificial lungs are increasingly being used for long-term applications. However, clot formation limits their use to 1-2 weeks. This study investigated the effect of nitric oxide generating (NOgen) hollow fibers on artificial lung thrombogenicity. Silicone hollow fibers were fabricated to incorporate 50 nm copper particles as a catalyst for NO generation from the blood. Fibers with and without (control) these particles were incorporated into artificial lungs with a 0.1 m(2) surface area and...
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