Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes.

Adam Feinberg, Crystal M. Ripplinger, Peter Van Der Meer, Sean P. Sheehy, Ibrahim Domian, Kenneth R. Chien & Kevin Kit Parker
Stem cell-derived cardiomyocytes represent unique tools for cell- and tissue-based regenerative therapies, drug discovery and safety, and studies of fundamental heart-failure mechanisms. However, the degree to which stem cell-derived cardiomyocytes compare to mature cardiomyocytes is often debated. We reasoned that physiological metrics of engineered cardiac tissues offer a means of comparison. We built laminar myocardium engineered from cardiomyocytes that were differentiated from mouse embryonic stem cell-derived cardiac progenitors or harvested directly from neonatal mouse ventricles,...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.