Generation of functional ventricular heart muscle from mouse ventricular progenitor cells.

Ibrahim Domian, Murali Chiravuri, Peter Van Der Meer, Adam Feinberg, Xi Shi, Ying Shao, Sean M. Wu, Kevin Kit Parker & Kenneth R. Chien
The mammalian heart is formed from distinct sets of first and second heart field (FHF and SHF, respectively) progenitors. Although multipotent progenitors have previously been shown to give rise to cardiomyocytes, smooth muscle, and endothelial cells, the mechanism governing the generation of large numbers of differentiated progeny remains poorly understood. We have employed a two-colored fluorescent reporter system to isolate FHF and SHF progenitors from developing mouse embryos and embryonic stem cells. Genome-wide profiling of...
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