Hemodynamic design requirements for in-series thoracic artificial lung attachment in a model of pulmonary hypertension.

Begum Akay, Julie A Foucher, Daniele Camboni, Kelly L. Koch, & Keith Cook
Recent thoracic artificial lung (TAL) prototypes have impedances lower than the natural lung. With these devices, proximal pulmonary artery (PA) to distal PA TAL attachment may be possible in patients without right ventricular dysfunction. This study examined the relationship between pulmonary system impedance and cardiac output (CO) to create TAL design constraints. A circuit with adjustable resistance and compliance (C) was attached in a PA-PA fashion with the pulmonary circulation of seven sheep with chronic...
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