Hierarchical architecture influences calcium dynamics in engineered cardiac muscle.

Terrence Pong, William J. Adams, Mark-Anthony Bray, Adam Feinberg, Sean P. Sheehy, Andreas A. Werdich & Kevin Kit Parker
Changes in myocyte cell shape and tissue structure are concurrent with changes in electromechanical function in both the developing and diseased heart. While the anisotropic architecture of cardiac tissue is known to influence the propagation of the action potential, the influence of tissue architecture and its potential role in regulating excitation-contraction coupling (ECC) are less well defined. We hypothesized that changes in the shape and the orientation of cardiac myocytes induced by spatial arrangement of...
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