Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor.

Xiaojie Duan, Ruixuan Gao, Ping Xie, Itzhaq Cohen-Karni, Quan Qing, Hwan Sung Choe, Bozhi Tian, Xiaocheng Jiang & Charles M. Lieber
The ability to make electrical measurements inside cells has led to many important advances in electrophysiology. The patch clamp technique, in which a glass micropipette filled with electrolyte is inserted into a cell, offers both high signal-to-noise ratio and temporal resolution. Ideally, the micropipette should be as small as possible to increase the spatial resolution and reduce the invasiveness of the measurement, but the overall performance of the technique depends on the impedance of the...
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