Investigating developmental cardiovascular biomechanics and the origins of congenital heart defects.

William J. Kowalski, Kerem Pekkan, Joseph P. Tinney & Bradley Keller
Innovative research on the interactions between biomechanical load and cardiovascular (CV) morphogenesis by multiple investigators over the past 3 decades, including the application of bioengineering approaches, has shown that the embryonic heart adapts both structure and function in order to maintain cardiac output to the rapidly growing embryo. Acute adaptive hemodynamic mechanisms in the embryo include the redistribution of blood flow within the heart, dynamic adjustments in heart rate and developed pressure, and beat to...
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