Left atrial ligation alters intracardiac flow patterns and the biomechanical landscape in the chick embryo.

William J. Kowalski, Nikola C. Teslovich, Prahlad G. Menon, Joseph P. Tinney, Bradley B. Keller & Kerem Pekkan
BACKGROUND: Hypoplastic left heart syndrome (HLHS) is a major human congenital heart defect that results in single ventricle physiology and high mortality. Clinical data indicate that intracardiac blood flow patterns during cardiac morphogenesis are a significant etiology. We used the left atrial ligation (LAL) model in the chick embryo to test the hypothesis that LAL immediately alters intracardiac flow streams and the biomechanical environment, preceding morphologic and structural defects observed in HLHS. RESULTS: Using fluorescent...
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