The Effect of Metabolic Substrate on ROS Production During Muscle Contraction

Adam James Amorese
Many different disease states are characterized by mitochondrial dysfunction, which results in excessive reactive oxygen species (ROS) production. In contrast muscle contraction induces ROS generation suggesting there is an optimal range of ROS production necessary for proper cell function. It is unclear if ROS production is influenced by metabolic substrate flux as a result of the energetic demand of contraction. The purpose of this study was to determine the rate and source of ROS production...
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