THE ROLE OF ENDOPLASMIC RETICULUM STRESS IN ETHANOL-INDUCED NEURODEGENERATION

yongchao wang
Heavy ethanoluse causes neurodegenerationmanifested byneuronal loss and dysfunction. It is becoming imperative to delineate the underlying mechanism to promote the treatment of ethanol-induced neurodegeneration. Endoplasmic reticulum (ER)stress is a hallmark and an underlying mechanism ofmany neurodegenerative diseases. This study aimsto investigate the role of ER stress in ethanol-induced neurodegeneration.In experimental design, adult mice were exposed tobinge ethanoldrinkingby daily gavage for 1, 5,or 10 daysand the response of ER stress was examined.We found the induction ofER...
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