A FRAMEWORK FOR HETEROLOGOUS BIOSYNTHESIS OF NATURAL PRODUCTS IN MAMMALIAN CELLS VIA POLYMER-MEDIATED TRANSFECTIONS

Logan Warriner
With the promise to treat a multi-faceted list of serious inherited and acquired diseases, such as cancer, neurodegenerative and infectious diseases, and inherited genetic indications, gene therapy has continued to push the boundaries of traditional medicine since its earliest implementation. While much progress has been made, clinical success has largely remained elusive. Immunogenicity, difficulty producing commercially relevant quantities, and having a limited genetic payload still limits the ability of viruses to act as directed delivery...
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