ELUCIDATING THE ROLE OF LIGHT-INDUCED CIRCADIAN DISRUPTION ON ATHEROSCLEROSIS IN APOLIPOPROTEINE-DEFICIENT MICE

Jeffrey Chalfant
Circadian rhythms are approximately 24-hour oscillations of nearly every biological process in the body. The circadian system coordinates these rhythms of physiology and behavior with environmental cycles such as the light-dark cycle. Shift workers, who experience irregular exposure to the light-dark cycle, have chronically disrupted circadian rhythms and increased risk of developing cardiovascular disease, but the mechanisms are unknown. Our studies investigated the effects of light-induced circadian disruption on atherosclerosis in ApolipoproteinE-deficient (ApoE-/-) mice. We...
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