INTERACTIONS OF POST-PKS ENZYMES OF THE MITHRAMYCIN BIOSYNTHETIC PATHWAY

Ryan Wheeler
Combinatorial biosynthesis is a powerful tool for generating new, more active drug analogues to combat disease. But in order for combinatorial biosynthesis to be employed to its full potential, a deep understanding of the enzymes that produce the parent molecule must be had. The goals of the work presented in this thesis are to characterize the reaction catalyzed by MtmW, the final enzyme in the mithramycin (MTM) biosynthetic pathway, and to discover the interaction between...
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