ClpXP Degradation System in Escherichia coli, a Study of Its Energy Sources and Its Applications in Managing the Expression Levels of Targeted Membrane and Soluble Proteins

Thilini Abeywansha
ClpXP is an Escherichia coli protease that carries out energy-dependent intracellular proteolysis. In recent years, this system has been widely studied due to its importance as protein regulatory machinery and a virulence factor. Protein substrates of ClpXP contain degrons with a specific protein sequence. SsrA tag is one of the five degrons known to designate proteins for ClpXP degradation. SsrA is an 11 amino acid peptide added to the C-terminus of nascent polypeptide chains translated...
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