Challenges and considerations in designing multidrug combinations for cancer treatment

Marloes Zoetemelk
This study aimed to investigate and improve the current standard of care chemotherapy combinations and optimize new targeted drug combinations for the improved treatment of colorectal carcinoma (CRC). We emphasize the relevance of various pre-clinical and clinical CRC systems for validation and clinical translation of drug combinations and establish a heterotypic 3D cell culture platform that can easily be adapted to improve other cancer cell cultures. We find that optimized low-dose cell-specific chemotherapy combinations did...
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