Dissecting the mechanism of action of an anti-TLR4 antibody

Jeremy Loyau
In order to treat Toll-like receptor 4 (TLR4)-mediated diseases, Hu 15C1, an antagonist antibody directed against human TLR4 has been developed. The potency of this antibody is enhanced by the co-engagement of TLR4 and Fc gamma receptors (FcγR), an intriguing mode of action that does not involve FcγR downstream signaling. In this thesis, we have explored the contribution of both the Fv and Fc regions to the efficacy of Hu 15C1. First, by using a...
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