Autophagy inhibitors and inducers as modulators of trimethyltin toxicity in neurons and glial cells

Cinzia Fabrizi, Elena Pompili, Francesca Somma, Francesco Fornai, Paola Lenzi & Lorenzo Fumagalli
Trimethyltin (TMT) is a triorganotin compound which determines neurodegeneration of specific brain areas particularly damaging the limbic system. Organotin compounds are used as heat stabilizers in polyvinyl chloride polymers, industrial and agricultural biocides, and industrial catalysts in chemical reactions. The mechanism underlying TMT selective tissue-specific pattern of cellular damage is not completely known unless a correlation exists between TMT toxicity and the expression of stannin, a highly-conserved protein mainly localized within mitochondria. Ultrastructural studies performed...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.