Sarcoglycan subcomplex on normal and pathological prostatic tissue: an immunohistochemical and molecular study

Angelo Favaloro, Alba Arco, Carlo Magno, Francesco Speciale & Ludovico Magaudda
The sarcoglycan complex (SGC) is a multimember transmembrane complex interacting with other member of dystrophin-glycoprotein complex (DGC) in order to provide a mechano-signaling connection from the cytoskeleton to the extracellular matrix in myocytes. Previous investigations have demonstrated that in skeletal and cardiac muscle, the SGC is a heterotetrameric unit constituted by the alfa, beta, gamma and delta-sarcoglycans. Other authors demonstrated that the expression of alfa-sarcoglycan is restricted to striated muscle cells, whereas epsilon-sarcoglycan, is also...
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