New role of oxysterols as regulators of adipogenic differentation in adipose-derived mesenchymal stem cells

Francesca Luchetti, Barbara Canonico, Erica Cesarini, Cristina Tortoioli, Marcella Arcangeletti, Laura Galli, Luigi Iuliano, Giuseppe Murdolo, Francesco Galli & Stefano Papa
Growing evidence indicates that adipose tissue (AT) represents a potential source of pluripotent mesenchymal stem cells. However, the mechanisms underlying the lineage-specific commitment of human adipose-derived stem cells (ASC) remain still not fully elucidated. Oxysterols are cholesterol oxide products resulting from non-enzymatic (ie, 7-Ketocolesterol) or enzymatic (ie, 5,6-Secosterol) oxidation of cholesterol, which are now emerging as reliable markers of adipose “oxidative stress” in vivo. Recent data suggest that, by regulating the adipogenic differentiation of ASC,...
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