A2A receptors and methamphetamine toxicity: a role of adenosine as an endogenous neurotoxin

Alessia Scatena, Michela Ferrucci, Paola Soldani, Silvio Paparelli, Federico Da Settimo & Antonio Paparelli
Adenosine A2A are a class of purinergic receptors largely expressed in dopamine (DA)-rich areas of the central nervous system. In particular, they are abundant within basal ganglia, where they modulate the activity of various neurotransmitters, including DA. Despite the lack of knowledge on their fine physiological mechanisms, it is worth to mention that A2A antagonists prevent neuronal death and dyskinesia in Parkinsonism. Moreover the neuroprotective effects observed after blockade of adenosine A2A receptors in several...
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