New route for Tizanidine administration: a pharmacokinetics and light microscope autoradiography study

Seyed Khosrow Tayebati, Innocent Ejike Nwankwo, Massimiliano Borsa, Enea Traini & Francesco Amenta
Spasticity could represent a complication of several central nervous system (CNS) disorders. Multiple sclerosis and painful paroxysmal syndromes (e.g. trigeminal neuralgia) are pathologies in which anti-spastic drugs are used to a greater extent . Baclofen, tizanidine (TIZ), benzodiazepines, dantrolene, and, more recently, gabapentin are the pharmacological agents more widely used. Baclofen, TIZ, benzodiazepines, gabapentin, clonidine but not dantrolene are active on CNS. The alpha2 adrenoceptor agonist TIZ is one of the most effective and largely...
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