Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors

Livio Trusolino
Despite expressing stem cell markers, basal-like breast tumors are proposed to derive from luminal progenitors, which are downstream of stem cells in the mammary epithelial hierarchy. However, the mechanisms that regulate this backward transition remain unclear. Using mouse models, we found that the Met receptor for HGF, which is frequently hyperactivated in basal-like tumors, is preferentially expressed in luminal progenitors. Constitutive activation of Met in purified progenitors stimulated clonogenic activity in vitro and conferred repopulating...
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