NG2 modulates tight junction integrity in brain microvessels

Daniela Virgintino, Mariella Errede, Francesco Girolamo, Marco Rizzi, Maurizio Strippoli, Giovanni Ferrara, Caterina Bendotti, Sara Morando, Antonio Uccelli, Roberto Perris, Roberto Furlan & Luisa Roncali
In this work we addressed the putative role of NG2 in the control of endothelial tight junction (TJ) dismantling, blood-brain barrier (BBB) breakdown, and leukocyte transendothelial migration in inflammatory/degenerative neurological disorders. During CNS development two cell types are known to express the transmembrane proteoglycan NG2, namely oligodendrocyte precursors (OPCs) and microvessel-associated pericytes. In both cell types expression of NG2 is a hallmark of cell activation in response to signalling molecules, mainly growth factors, and via...
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