Cytoprotective effects of melatonin in C2C12 skeletal muscle cells: a multiple technical approach

Valentina Baldassarri, Sara Salucci, Davide Curzi, Sabrina Burattini & Elisabetta Falcieri
Melatonin has a wide range of physiological functions including protection against oxidative stress, which is carried out through its ability to act as a free radical scavenger and to stimulate antioxidant enzyme production (Allegra et al., 2003). Oxidative stress is a major player in initiating apoptosis in skeletal muscle, as well as in other tissues. Apoptosis is essential for skeletal muscle development and homeostasis; nevertheless, its misregulation has been frequently observed in various myopathies (Loro...
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