The parkinsonism-inducing neurotoxin MPTP produces severe changes in the cervical spinal cord

Alessia Bartalucci, Larisa Ryskalin, Paola Parlanti, Cristina Demi, Giorgio Vivacqua & Antonio Paparelli
The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is commonly used in experimental parkinsonism due to its capacity to induce degeneration of nigrostriatal dopaminergic neurons and locus coeruleus noradrenaline-containing neurons. Recently it was demonstrated that administration of MPTP to mice induces spinal cord alterations consisting of changes in the alpha-synuclein immunostaining and loss of motor neurons. Interestingly, a relationship between motor neuron degeneration and motor symptoms has been reported also in Parkinson’s disease (PD) patients. On the other hand,...
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