NPP1 inhibits intimal hyperplasia in ApoE knockout mice

Francesca Bonomini, Frank Rutsch, Yvonne Nitschke, Stefania Castrezzati & Rita Rezzani
Atherosclerosis is an important cause of morbidity and mortality, which is increasingly recognized and reported on a global scale. This pathology is due to multiple metabolic toxicity including increased levels of reactive oxygen species (ROS). Excessive ROS are damaging to proteins, lipids, carbohydrates and nucleic acids, which prompt a classic “response to injury” mechanism including inflammation supporting a cytokine surge, granulation and fibrosis. ROS are excessive, robustly produced in atherosclerosis associated with endothelial dysfunction. Excessive...
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