Early differentiating osteoclast interactions with a well suitable bone-like composite

Roberta Bortul, Giovanna Baldini, Gianluca Turco, Francesco Princivalle, Vanessa Nicolin & Vittorio Grill
Osteoclasts, as well as preosteoclasts, show different adhesion features in relationship to the substrate on which cells are grown, i.e. the formation of either podosomes belt or sealing zones. Podosomes belt forms on non bone substrates, i.e. when cells interact with glass coverslips or culture plates, whereas sealing zones form when cells grow on bone-like substrates. Podosomes belt corresponds to numerous F-actin columns arranged at the cell periphery, whereas the sealing zone could be defined...
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