α-Actinin behavior during C2C12 along differentiation

Sabrina Burattini, Valentina Baldassarri, Sara Salucci, Paola Ferri & Elisabetta Falcieri
α-Actinin is a cytoskeletal actin-binding protein (Ogura et al., 2009) that provides structural integrity of the sarcomeres and is located in the skeletal muscle Z-lines. It creates cross-links between actin filaments and, besides, it contributes to cytoskeleton organization and muscle contraction (Sjöblom et al., 2008). The aim of this work was to clear up the behavior of sarcomeric α-actinin in Z-lines formation during myogenic differentiation. For this purpose, C2C12 cells were analyzed at 0, 3,...
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